PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	UBXN6	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Choudhury NR (2017)	2
UBXN2A	1	PPP1R11	0	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Huttlin EL (2017)	2
PPP1R7	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	6
UBXN2A	1	PPP1CA	3	affinity chromatography technology	Raman M (2015)	1
UBXN6	1	UBXN2A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN2A	1	UBXN10	2	affinity chromatography technology	Raman M (2015)	1
VCP	6	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Alexandru G (2012), Yu CC (2013), Fogeron ML (2013), Rolland T (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Hein MY (2015), Raman M (2015), Huttlin EL (2017)	14
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
ASPSCR1	3	PHAX	0	two hybrid	Vinayagam A (2011)	1
PPP1R7	4	UBXN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Huttlin EL (2017)	3
NSFL1C	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Huttlin EL (2017)	2
VCP	6	UBXN2A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Vinayagam A (2011), Fogeron ML (2013), Raman M (2015), Raman M (2015), Huttlin EL (2017)	6
UBXN2A	1	MYLPF	1	affinity chromatography technology	Raman M (2015)	1
UBXN2A	1	HSPA9	2	two hybrid, affinity chromatography technology	Sane S (2016), Sane S (2016)	2
VCPIP1	4	UBXN2A	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
LIMA1	4	PPP1CA	3	affinity chromatography technology	Hein MY (2015)	1
UBXN6	1	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
TRIM25	5	PPP1CB	9	affinity chromatography technology	Choudhury NR (2017)	1
UBXN2A	1	LACTB	0	affinity chromatography technology	Raman M (2015)	1
UBXN6	1	LIMA1	4	affinity chromatography technology	Haines DS (2012)	1
MYH11	8	UBXN2A	1	affinity chromatography technology	Hein MY (2015)	1
PPP1CA	3	PPP1R11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	6
UBXN6	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haines DS (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	4
UBXN2A	1	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
UBXN2A	1	DBI	0	two hybrid	Vinayagam A (2011)	1
VCPIP1	4	NSFL1C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Alexandru G (2008), Uchiyama K (2002), Raman M (2015)	4
UBXN2A	1	PHAX	0	two hybrid	Vinayagam A (2011)	1
NSFL1C	1	PHAX	0	two hybrid	Vinayagam A (2011)	1
TRIM25	5	PPP1CA	3	affinity chromatography technology	Choudhury NR (2017)	1
NSFL1C	1	DBI	0	two hybrid	Vinayagam A (2011)	1
NSFL1C	1	LACTB	0	affinity chromatography technology	Raman M (2015)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
PPP1CB	9	UBXN2A	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Raman M (2015)	2
PPP1CB	9	PPP1R11	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Ewing RM (2007), Wan C (2015), Hein MY (2015), St-Denis N (2016), Boldt K (2016), Yadav L (2017), Yadav L (2017)	7
PPP1R7	4	PPP1R11	0	affinity chromatography technology	Boldt K (2016)	1
PPP1CB	9	PPP1R7	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Ewing RM (2007), Wan C (2015), Hein MY (2015), St-Denis N (2016), Boldt K (2016), Yadav L (2017), Yadav L (2017)	7
LIMA1	4	UBXN2A	1	affinity chromatography technology	Hein MY (2015)	1
UBXN6	1	NSFL1C	1	affinity chromatography technology	Raman M (2015)	1
UBXN10	2	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015), Raman M (2015)	3
UBXN6	1	VCP	6	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kern M (2009), Kern M (2009), Kern M (2009), Stapf C (2011), Stapf C (2011), Stapf C (2011), Alexandru G (2008), Haenzelmann P (2011), Haenzelmann P (2011), Allen MD (2006), Nagahama M (2009), Nagahama M (2009), Alexandru G (2012), Haines DS (2012), Yu CC (2013), Huttlin EL (2015), Madsen L (2014), Trusch F (2015), Raman M (2015), Raman M (2015), Guo X (2017), Guo X (2017), Huttlin EL (2017)	23
UBXN10	2	NSFL1C	1	affinity chromatography technology	Raman M (2015)	1
UBXN2A	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Huttlin EL (2017)	2
PPP1CB	9	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
UBXN10	2	ASPSCR1	3	affinity chromatography technology	Raman M (2015)	1
VCP	6	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Uchiyama K (2003), Uchiyama K (2003), Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Madsen L (2011), Fernandez-Saiz V (2010), Noguchi M (2005), Uchiyama K (2002), Uchiyama K (2002), Uchiyama K (2002), Alexandru G (2012), Fogeron ML (2013), Grelle G (2006), Grelle G (2006), Grelle G (2006), Rolland T (2014), Besten Wd (2012), Madsen L (2014), Zhang X (2015), Wan C (2015), Hein MY (2015), Raman M (2015), Raman M (2015), Wang T (2016), Guo X (2017), Park ES (2017), Huttlin EL (2017)	28
VCPIP1	4	VCP	6	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Totsukawa G (2011), Totsukawa G (2013), Totsukawa G (2013), Zhang X (2014), Raman M (2015)	6
TRIM25	5	UBXN2A	1	affinity chromatography technology	Choudhury NR (2017)	1
UBXN10	2	UBXN6	1	affinity chromatography technology	Raman M (2015)	1
ASPSCR1	3	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1