PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VIM	0	DES	1	affinity chromatography technology	Huttlin EL (2017)	1
DLST	3	HSPB1	2	affinity chromatography technology	Malty RH (2017)	1
DES	1	HADHB	4	biochemical	Havugimana PC (2012)	1
SHBG	0	DES	1	two hybrid	Pope SN (2005)	1
UBE2I	0	TRIM63	0	two hybrid	McElhinny AS (2002)	1
RPL17	0	RPL29	0	biochemical	Havugimana PC (2012)	1
DES	1	EHHADH	1	two hybrid	Rolland T (2014)	1
CFTR	5	HNRNPUL1	1	affinity chromatography technology	Pankow S (2015)	1
SYNM	3	DES	1	pull down	Mizuno Y (2001)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
HSPB1	2	DES	1	two hybrid	Katsogiannou M (2014)	1
YWHAQ	0	CAPN1	3	biochemical	Kristensen AR (2012)	1
NEFM	0	DES	1	affinity chromatography technology	Huttlin EL (2017)	1
SP1	0	VIM	0	affinity chromatography technology	Chuang JY (2012)	1
DES	1	S100A1	1	pull down	Garbuglia M (1996)	1
YWHAQ	0	VIM	0	affinity chromatography technology, pull down, biochemical	Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010)	3
CRYAB	0	HSPB1	2	biochemical, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Kato K (1992), Kato K (1992), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003), MacIntyre DA (2008), Zhang H (2010), Delbecq SP (2012), Aquilina JA (2013), DeGrado-Warren J (2008), Huttlin EL (2015), Huttlin EL (2017)	13
HSPB1	2	UBE2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brunet Simioni M (2009), Ahner A (2013), Ahner A (2013)	3
UBE2I	0	TRIM55	2	two hybrid, affinity chromatography technology	McElhinny AS (2002), Lange S (2005)	2
PLEKHA5	2	SPTAN1	9	two hybrid	Bandyopadhyay S (2010)	1
ITSN1	5	DES	1	two hybrid	Wong KA (2012)	1
CFTR	5	MYL6	2	affinity chromatography technology	Pankow S (2015)	1
TRIM63	0	EHHADH	1	two hybrid	Witt CC (2008)	1
HSPB1	2	VIM	0	two hybrid	Katsogiannou M (2014)	1
SOD1	0	CCT7	2	affinity chromatography technology	Malty RH (2017)	1
CRYAB	0	GFAP	0	pull down	Ghosh JG (2007)	1
BRCA1	7	JUP	7	two hybrid	Wang J (2011)	1
SP1	0	DES	1	affinity chromatography technology	Chuang JY (2012)	1
SHBG	0	SNRNP70	2	two hybrid	Pope SN (2005)	1
MAPKAPK2	1	HSPB1	2	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Rane MJ (2001), Uddin S (2002), Coxon PY (2003), Rogalla T (1999), Werz O (2002), Clifton AD (1996), Rane MJ (2001), Sun L (2007), Chen TC (2014), Krump E (1997), Chrestensen CA (2004), Chang E (2011), Maitra S (2008), Rane MJ (2003), Singh S (2003), Chen G (2000), Eyers CE (2005), Tollenaere MA (2015)	18
CFTR	5	DSP	8	affinity chromatography technology	Pankow S (2015)	1
AURKB	2	GFAP	0	enzymatic study	Kawajiri A (2003)	1
730211	0	RPL17	0	biochemical	Havugimana PC (2012)	1
BRCA1	7	HSPB1	2	affinity chromatography technology	Ertych N (2016)	1
MLH1	6	DES	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Brieger A (2010), Brieger A (2010), Brieger A (2010)	3
YWHAQ	0	HSPB1	2	affinity chromatography technology, two hybrid	Pozuelo-Rubio M (2010), Katsogiannou M (2014)	2
CFTR	5	DES	1	affinity chromatography technology	Pankow S (2015)	1
GFAP	0	DES	1	affinity chromatography technology	Huttlin EL (2017)	1
NEFM	0	GFAP	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM63	0	NEB	21	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
CFTR	5	VIM	0	affinity chromatography technology	Pankow S (2015)	1
DSP	8	JUP	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Kowalczyk AP (1998), Kowalczyk AP (1997), Kowalczyk AP (1997)	3
DES	1	CCT7	2	biochemical	Havugimana PC (2012)	1
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
AURKB	2	DES	1	enzymatic study	Kawajiri A (2003)	1
GLI1	3	DES	1	affinity chromatography technology	Li X (2015)	1
PDHA1	7	HSPB1	2	affinity chromatography technology	Malty RH (2017)	1
CFTR	5	MOV10	6	affinity chromatography technology	Pankow S (2015)	1
MLH1	6	SPTAN1	9	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Brieger A (2010), Brieger A (2010), Brieger A (2010), Wan C (2015)	4
PDHA1	7	DSP	8	affinity chromatography technology	Malty RH (2017)	1
SYNC	0	GFAP	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPKAPK2	1	DES	1	two hybrid	Yannoni YM (2004)	1
NEB	21	DES	1	two hybrid	Bang ML (2001)	1
YWHAQ	0	DES	1	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Pozuelo-Rubio M (2010)	2
DES	1	RPL29	0	biochemical	Havugimana PC (2012)	1
CFTR	5	DLST	3	affinity chromatography technology	Pankow S (2015)	1
DSP	8	DES	1	pull down, two hybrid	Meng JJ (1997), Meng JJ (1997)	2
DES	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
BRCA1	7	MLH1	6	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cannavo E (2007), Suhasini AN (2011), Hill SJ (2014)	4
DES	1	JUP	7	biochemical	Havugimana PC (2012)	1
MOV10	6	MAPKAPK2	1	affinity chromatography technology	Castello A (2012)	1
DES	1	730211	0	biochemical	Havugimana PC (2012)	1
DES	1	HNRNPUL1	1	biochemical	Havugimana PC (2012)	1
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
MLH1	6	MYL6	2	two hybrid	Brieger A (2010)	1
BRCA1	7	RPL17	0	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	CCT7	2	affinity chromatography technology	Ertych N (2016)	1
DES	1	SNRNP70	2	biochemical	Havugimana PC (2012)	1
VIM	0	NEFM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
SOD1	0	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
BRCA1	7	PPP1R18	2	affinity chromatography technology	Woods NT (2012)	1
DES	1	RPL17	0	biochemical	Havugimana PC (2012)	1
UBE2I	0	CFTR	5	enzymatic study, enzymatic study	Ahner A (2013), Gong X (2016)	2
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
DLST	3	DSP	8	affinity chromatography technology	Malty RH (2017)	1
GFAP	0	VIM	0	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
VIM	0	SPTAN1	9	affinity chromatography technology, affinity chromatography technology	Brown MJ (2001), Brown MJ (2001)	2
TRIM55	2	EHHADH	1	two hybrid	Witt CC (2008)	1
UBE2I	0	AURKB	2	enzymatic study	Ban R (2011)	1
DSP	8	VIM	0	pull down, two hybrid	Meng JJ (1997), Meng JJ (1997)	2
SOD1	0	CRYAB	0	pull down	Yerbury JJ (2013)	1
CAPN1	3	VIM	0	two hybrid, affinity chromatography technology	Jiang LQ (2002), Huttlin EL (2017)	2
VIM	0	SYNC	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
SYNC	0	NEFM	0	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	CCT7	2	affinity chromatography technology	Castello A (2012)	1
TRIM55	2	NEB	21	two hybrid	Witt CC (2008)	1
TRIM55	2	DES	1	two hybrid	Witt CC (2008)	1
TRIM63	0	DES	1	two hybrid	Witt CC (2008)	1
BRCA1	7	HNRNPUL1	1	affinity chromatography technology	Ertych N (2016)	1
SPTAN1	9	DES	1	biochemical	Langley RC (1986)	1
CRYAB	0	DES	1	pull down	Ghosh JG (2007)	1
BRCA1	7	DSP	8	affinity chromatography technology	Ertych N (2016)	1
MOV10	6	DES	1	affinity chromatography technology	Castello A (2012)	1
CAPN1	3	SPTAN1	9	enzymatic study	Stabach PR (1997)	1
CAPN1	3	NEFM	0	affinity chromatography technology	Huttlin EL (2017)	1
DES	1	MYL6	2	biochemical	Havugimana PC (2012)	1
CFTR	5	SPTAN1	9	affinity chromatography technology	Pankow S (2015)	1
CAPN1	3	DES	1	two hybrid	Jiang LQ (2002)	1
BRCA1	7	RPL29	0	affinity chromatography technology	Ertych N (2016)	1
CFTR	5	HSPB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahner A (2013), Wang X (2006), Gong X (2016), Pankow S (2015)	4
SYNC	0	SYNM	3	affinity chromatography technology	Huttlin EL (2017)	1
PDHA1	7	DES	1	affinity chromatography technology	Malty RH (2017)	1
SYNC	0	DES	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Poon E (2002), Poon E (2002), Huttlin EL (2017)	3
SPATA22	1	DES	1	affinity chromatography technology	Huttlin EL (2017)	1
DLST	3	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
BRCA1	7	YWHAQ	0	affinity chromatography technology	Ertych N (2016)	1
PDHA1	7	NEFM	0	affinity chromatography technology	Malty RH (2017)	1
DES	1	UBE2I	0	two hybrid	Rolland T (2014)	1
SOD1	0	DES	1	affinity chromatography technology	Malty RH (2017)	1
BRCA1	7	SPTAN1	9	affinity chromatography technology	Ertych N (2016)	1
DES	1	PPP1R18	2	two hybrid	Rolland T (2014)	1
DLST	3	CCT7	2	affinity chromatography technology	Malty RH (2017)	1
AURKB	2	PLEKHA5	2	affinity chromatography technology	Fogeron ML (2013)	1
PLEKHA5	2	DES	1	two hybrid	Bandyopadhyay S (2010)	1
DLST	3	DES	1	affinity chromatography technology	Malty RH (2017)	1
SP1	0	NEB	21	affinity chromatography technology	Chuang JY (2012)	1
AURKB	2	730211	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2