PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	ZBTB14	2	affinity chromatography technology	Gorski JJ (2011)	1
LMNA	2	FAM9B	0	two hybrid	Dittmer TA (2014)	1
KIFC3	3	TCEANC	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	TCEANC	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
MEOX1	0	TCEANC	0	two hybrid	Rolland T (2014)	1
TCEANC	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
MID1	1	TCEANC	0	two hybrid	Rolland T (2014)	1
TARBP2	0	IKBKG	0	two hybrid	Ravasi T (2010)	1
BRCA1	7	YWHAE	0	affinity chromatography technology	Ertych N (2016)	1
NINL	1	TCEANC	0	two hybrid	Rual JF (2005)	1
DAB1	1	HMBOX1	2	two hybrid	Rolland T (2014)	1
DAB1	1	APP	1	pull down, pull down	Homayouni R (1999), Olah J (2011)	2
IKBKG	0	TCEANC	0	pull down	Fenner BJ (2010)	1
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
CRACR2B	3	APP	1	pull down	Olah J (2011)	1
TCEANC	0	BRCA1	7	two hybrid, genetic interference	Hill SJ (2014), Hill SJ (2014)	2
HMBOX1	2	TCEANC	0	two hybrid	Rolland T (2014)	1
RAD54B	3	TCEANC	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NEDD4	2	KIFC3	3	pull down	Persaud A (2009)	1
KIFC3	3	SPERT	0	two hybrid	Rolland T (2014)	1
TCEANC	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
HMBOX1	2	APP	1	pull down	Olah J (2011)	1
TCEANC	0	CRACR2B	3	two hybrid	Rolland T (2014)	1
NINL	1	SPERT	0	two hybrid	Rual JF (2005)	1
ZKSCAN7	2	TCEANC	0	two hybrid, two hybrid	Rual JF (2005), Ravasi T (2010)	2
CCDC85B	0	CARD9	3	two hybrid	Rual JF (2005)	1
KRTAP5-9	0	TCEANC	0	two hybrid	Rolland T (2014)	1
VPS52	0	TCEANC	0	two hybrid	Rolland T (2014)	1
CCDC85B	0	TCEANC	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
MEOX1	0	MID1	1	two hybrid	Rolland T (2014)	1
VAC14	5	APP	1	pull down	Olah J (2011)	1
VAC14	5	TCEANC	0	two hybrid	Rolland T (2014)	1
CARD9	3	HMBOX1	2	two hybrid	Rolland T (2014)	1
TARBP2	0	TCEANC	0	two hybrid	Rolland T (2014)	1
LMNA	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
ZBTB14	2	TCEANC	0	two hybrid	Rolland T (2014)	1
KRTAP4-2	0	TCEANC	0	two hybrid	Rolland T (2014)	1
KRTAP5-9	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
TCEANC	0	SPERT	0	two hybrid	Rolland T (2014)	1
KRTAP5-9	0	KRTAP4-2	0	two hybrid	Rolland T (2014)	1
MEOX1	0	APP	1	pull down	Olah J (2011)	1
NINL	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Jin S (2009), Jin S (2009)	2
CARD9	3	TCEANC	0	two hybrid	Rolland T (2014)	1
KIFC3	3	APP	1	pull down	Olah J (2011)	1
ATXN1	2	YWHAE	0	two hybrid	Suter B (2013)	1
NAB2	2	TCEANC	0	two hybrid	Rolland T (2014)	1
LMNA	2	TCEANC	0	two hybrid	Dittmer TA (2014)	1
SSNA1	0	TCEANC	0	two hybrid	Rolland T (2014)	1
RNF219	1	TCEANC	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KIFC3	3	TRAF2	1	two hybrid	Rolland T (2014)	1
YWHAE	0	TCEANC	0	pull down	Satoh J (2006)	1
KRTAP10-7	0	APP	1	pull down	Olah J (2011)	1
TARBP2	0	APP	1	pull down	Olah J (2011)	1
PNMA1	0	TCEANC	0	two hybrid	Rolland T (2014)	1
LMNA	2	MEOX1	0	two hybrid	Dittmer TA (2014)	1
NEDD4	2	TCEANC	0	pull down	Persaud A (2009)	1
MAGEA11	1	TCEANC	0	two hybrid	Rual JF (2005)	1
TRAF2	1	TCEANC	0	two hybrid	Rual JF (2005)	1
FBXO25	1	TCEANC	0	enzymatic study	Teixeira FR (2013)	1
ATXN1	2	TRAF2	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
FSD2	4	TCEANC	0	two hybrid	Rolland T (2014)	1
LMNA	2	NAB2	2	two hybrid	Dittmer TA (2014)	1
DAB1	1	TCEANC	0	two hybrid	Rolland T (2014)	1
TCEANC	0	LURAP1	0	two hybrid	Rual JF (2005)	1
KRTAP4-2	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
TCEANC	0	FAM9B	0	two hybrid	Rolland T (2014)	1
ATXN1	2	TCEANC	0	two hybrid	Lim J (2006)	1
CSRNP1	0	TCEANC	0	two hybrid	Rolland T (2014)	1