PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BAP1	4	ASXL1	15	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Scheuermann JC (2010), Yu H (2010), Bott M (2011), Bott M (2011), Abdel-Wahab O (2012), Daou S (2015), Daou S (2015), Daou S (2015), Sahtoe DD (2016), LaFave LM (2015), Hauri S (2016), Hauri S (2016)	14
ASXL1	15	PSMC6	0	affinity chromatography technology	Hauri S (2016)	1
CEBPA	0	ASXL1	15	affinity chromatography technology	Bararia D (2008)	1
HCFC1	4	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003), Mazars R (2010), Daou S (2011), Capotosti F (2011), Capotosti F (2011), Capotosti F (2011), Havugimana PC (2012), Hauri S (2016)	9
BAP1	4	FOXK2	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Okino Y (2015), Okino Y (2015), Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014), Ji Z (2014), Shan L (2016), Shan L (2016), Shan L (2016), Hauri S (2016)	15
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
PSMC4	6	PSMC2	2	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Hartmann-Petersen R (2001), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
ASXL1	15	PGAM5	4	affinity chromatography technology	Hauri S (2016)	1
EED	1	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
BAP1	4	PSMC2	2	affinity chromatography technology	Hauri S (2016)	1
UBC	7	BAP1	4	pull down, pull down, pull down, pull down	Duerksen-Hughes PJ (1989), Daou S (2015), Kwasna D (2018), Hanpude P (2017)	4
HIST1H1C	2	EED	1	pull down, affinity chromatography technology	Martin C (2006), Cao Q (2014)	2
ASXL1	15	PSMC5	4	affinity chromatography technology	Hauri S (2016)	1
BAP1	4	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
TUBA1C	1	PGAM5	4	affinity chromatography technology	Hein MY (2015)	1
PSMC2	2	PSMD8	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Grune T (2011), Kim YC (2011), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	7
PSMC4	6	PSMD8	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
ASXL1	15	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
UBC	7	OGT	4	pull down	Zhang X (2017)	1
ASXL1	15	PSMD8	1	affinity chromatography technology	Hauri S (2016)	1
ASXL1	15	PSMC2	2	affinity chromatography technology	Hauri S (2016)	1
ASXL1	15	HCFC1	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
ASXL1	15	MBD6	5	affinity chromatography technology	Hauri S (2016)	1
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
PSMC5	4	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Kim YC (2011), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
EZH2	4	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Cha TL (2005), Cha TL (2005), Cha TL (2005)	3
BAP1	4	PGAM5	4	affinity chromatography technology	Hauri S (2016)	1
ASXL1	15	EED	1	affinity chromatography technology	Abdel-Wahab O (2012)	1
BAP1	4	PSMC4	6	affinity chromatography technology	Hauri S (2016)	1
ASXL1	15	OGT	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
FOXK1	5	FOXK2	9	affinity chromatography technology	Li X (2015)	1
TUBA1C	1	PSMC5	4	affinity chromatography technology	Hein MY (2015)	1
UBC	7	PSMC6	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
PSMC2	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
ASXL1	15	MBD5	14	affinity chromatography technology	Hauri S (2016)	1
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
ASXL1	15	RPL39	0	affinity chromatography technology	Hauri S (2016)	1
BAP1	4	PSMD8	1	affinity chromatography technology	Hauri S (2016)	1
ASXL1	15	APP	1	pull down	Olah J (2011)	1
SRPK1	2	ASXL1	15	enzymatic study	Varjosalo M (2013)	1
PSMC2	2	PSMC6	0	biochemical, biochemical, biochemical, biochemical	Tipler CP (1997), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
EED	1	AR	3	affinity chromatography technology	Cao Q (2014)	1
PSMC5	4	PSMC6	0	pull down, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hartmann-Petersen R (2001), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
ASXL1	15	EZH2	4	affinity chromatography technology, affinity chromatography technology	Abdel-Wahab O (2012), Abdel-Wahab O (2012)	2
BAP1	4	FOXK1	5	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Okino Y (2015), Okino Y (2015), Okino Y (2015), Li X (2015), Hauri S (2016)	8
ASXL1	15	FOXK1	5	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
AR	3	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Matsuda T (2001), Ueda T (2002), Yamamoto T (2003), Yamamoto T (2003)	4
CEBPA	0	AR	3	pull down	Boruk M (1998)	1
BAP1	4	PSMC6	0	affinity chromatography technology	Hauri S (2016)	1
AKT1	1	ASXL1	15	two hybrid, affinity chromatography technology	Wang J (2008), Wang J (2008)	2
BAP1	4	HCFC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Machida YJ (2009), Machida YJ (2009), Machida YJ (2009), Yu H (2010), Yu H (2010), Yu H (2010), Yu H (2010), Pena-Llopis S (2012), Pena-Llopis S (2012), Bott M (2011), Bott M (2011), Misaghi S (2009), Mashtalir N (2014), Eletr ZM (2013), Eletr ZM (2013), Daou S (2015), Hauri S (2016)	19
FOXK2	9	ASXL1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Daou S (2015), Hauri S (2016)	3
UBC	7	ASXL1	15	pull down	Daou S (2015)	1
EED	1	HCFC1	4	affinity chromatography technology	Cao Q (2014)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
BAP1	4	OGT	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yu H (2010), Mashtalir N (2014), Daou S (2015), Hauri S (2016), Hauri S (2016)	6
ASXL1	15	PSMC4	6	affinity chromatography technology	Hauri S (2016)	1
AKT1	1	PSMC5	4	two hybrid	Arroyo R (2015)	1
PSMC4	6	PSMC6	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
ASXL1	15	STAT3	0	two hybrid	Wang J (2011)	1
HIST1H1C	2	ASXL1	15	affinity chromatography technology, affinity chromatography technology, pull down	Kim K (2008), Kim K (2008), Kim K (2008)	3
FOXK1	5	HCFC1	4	affinity chromatography technology	Okino Y (2015)	1
BAP1	4	PSMC5	4	affinity chromatography technology	Hauri S (2016)	1
SRPK1	2	APP	1	pull down	Olah J (2011)	1
BAP1	4	MBD6	5	affinity chromatography technology	Hauri S (2016)	1
UBC	7	PSMC4	6	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
FOXK2	9	HCFC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014)	5
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
OGT	4	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
UBC	7	PSMD8	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
PSMC6	0	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
AR	3	ASXL1	15	affinity chromatography technology	Grasso CS (2012)	1
EZH2	4	AR	3	affinity chromatography technology	Cao Q (2014)	1