PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	SYNPO2	1	affinity chromatography technology	Emdal KB (2015)	1
SYNPO2	1	MAP1LC3A	0	affinity chromatography technology	Ulbricht A (2013)	1
SYNPO2	1	STX7	2	affinity chromatography technology	Ulbricht A (2013)	1
NTRK1	1	VPS18	4	affinity chromatography technology	Emdal KB (2015)	1
BAG3	4	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gamerdinger M (2009), Gamerdinger M (2009), Chen Y (2013)	3
SYNPO2	1	HSPA8	4	affinity chromatography technology	Ulbricht A (2013)	1
PLK4	1	SYNPO2	1	affinity chromatography technology	Hein MY (2015)	1
BAG3	4	YWHAG	5	affinity chromatography technology	Chen Y (2013)	1
STX7	2	VPS18	4	affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001)	2
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
FLNC	8	SYNPO2	1	two hybrid, pull down	Linnemann A (2010), Linnemann A (2010)	2
SYNPO2	1	SQSTM1	0	affinity chromatography technology	Ulbricht A (2013)	1
NTRK1	1	YWHAZ	1	affinity chromatography technology	Emdal KB (2015)	1
SYNPO2	1	ACTN2	2	pull down	Linnemann A (2010)	1
NTRK1	1	HSPA8	4	affinity chromatography technology	Emdal KB (2015)	1
HSPA8	4	BAG3	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Takayama S (1999), Takayama S (1999), Takayama S (1999), Gentilella A (2011), Hishiya A (2011), Chen Y (2013), Chen Y (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Hein MY (2015)	11
SYNPO2	1	VPS18	4	two hybrid, affinity chromatography technology	Ulbricht A (2013), Ulbricht A (2013)	2
SQSTM1	0	YWHAZ	1	pull down	Pridgeon JW (2004)	1
YWHAG	5	SYNPO2	1	two hybrid	Bandyopadhyay S (2010)	1
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
NTRK1	1	FLNA	10	affinity chromatography technology	Emdal KB (2015)	1
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
NTRK1	1	YWHAG	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CDK6	0	affinity chromatography technology	Emdal KB (2015)	1
RHOA	0	SYNPO2	1	affinity chromatography technology	Hein MY (2015)	1
BAG3	4	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013), Chen Y (2013)	3
SYNPO2	1	ATG16L1	1	affinity chromatography technology	Ulbricht A (2013)	1
CDK6	0	SYNPO2	1	enzymatic study	Anders L (2011)	1
IPO13	6	SYNPO2	1	affinity chromatography technology, affinity chromatography technology	Liang J (2008), Liang J (2008)	2
SYNPO2	1	BAG3	4	affinity chromatography technology	Ulbricht A (2013)	1
POLK	0	SYNPO2	1	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	IPO13	6	affinity chromatography technology	Emdal KB (2015)	1
YWHAZ	1	SYNPO2	1	two hybrid	Bandyopadhyay S (2010)	1
SYNPO2	1	FLNA	10	affinity chromatography technology, two hybrid	Ulbricht A (2013), Linnemann A (2010)	2