Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
DHFR 1719 CHEMBL50514 CHEMBL50514 DrugBank 17139284, 17016423, 10592235
DHFR 1719 CHEMBL151958 CHEMBL151958 DrugBank 17139284, 17016423, 10592235
DHFR 1719 TALOTREXIN CHEMBL590985 TdgClinicalTrial
DHFR 1719 METOPRINE CHEMBL264373 inhibitor TTD
DHFR 1719 CHLORPROGUANIL CHEMBL1213553 inhibitor TTD
DHFR 1719 METHOTREXATE SODIUM CHEMBL3244648 inhibitor ChemblInteractions
DHFR 1719 MEPROBAMATE CHEMBL979 inhibitor TTD
DHFR 1719 PYRIMETHAMINE CHEMBL36 inhibitor DrugBank, TTD 12951104, 11752352, 9108546, 9380737
DHFR 1719 CHEMBL32190 CHEMBL32190 DrugBank 17139284, 17016423, 10592235
DHFR 1719 CHEMBL1161862 CHEMBL1161862 DrugBank 17139284, 17016423
DHFR 1719 PIRITREXIM CHEMBL7492 DrugBank 17139284, 17016423, 10592235
DHFR 1719 CHEMBL36245 CHEMBL36245 DrugBank 10592235
DHFR 1719 CHEMBL485961 CHEMBL485961 DrugBank 10592235
DHFR 1719 FOLIC ACID CHEMBL1622 NCI 10956384
DHFR 1719 RALTITREXED CHEMBL225071 NCI 9816025, 8698629
DHFR 1719 TAMOXIFEN CHEMBL83 NCI 3978632
DHFR 1719 CHEMBL1161866 CHEMBL1161866 DrugBank 17032644, 17115689
DHFR 1719 TRIMETREXATE CHEMBL119 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 11752352, 12649191, 12416030, 11448221, 10386066, 11752096, 10091649
DHFR 1719 METHOTREXATE CHEMBL34259 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, NCI 1489988, 6831441, 7346712, 8162600, 944698, 14679136, 1533575, 7057421, 9129
DHFR 1719 CHEMBL325434 CHEMBL325434 DrugBank 10592235
DHFR 1719 CHEMBL32113 CHEMBL32113 DrugBank 17139284, 17016423, 10592235
DHFR 1719 CHEMBL575218 CHEMBL575218 DrugBank 10592235
DHFR 1719 CHEMBL576960 CHEMBL576960 DrugBank 10592235
DHFR 1719 CHEMBL301769 CHEMBL301769 DrugBank 10592235
DHFR 1719 AMINOPTERIN CHEMBL376180 inhibitor TTD
DHFR 1719 TRIMETHOPRIM CHEMBL22 inhibitor DrugBank, TTD 14629008, 15561838, 11752352, 15115391, 14632594, 15504856
DHFR 1719 CHLOROGUANIDE CHEMBL1377 inhibitor DrugBank, TTD 10068594, 11752352, 12667224, 10998224, 11295178, 11740746
DHFR 1719 PEMETREXED (CHEMBL1201258) CHEMBL1201258 inhibitor TdgClinicalTrial, ClearityFoundationClinicalTrial, GuideToPharmacologyInteractions, TEND
DHFR 1719 PRALATREXATE CHEMBL1201746 inhibitor TdgClinicalTrial, ClearityFoundationClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 23409799
DHFR 1719 CHEMBL459177 CHEMBL459177 DrugBank 10592235
DHFR 1719 CHEMBL573077 CHEMBL573077 DrugBank 10592235
DHFR 1719 MITOMYCIN CHEMBL105 NCI 1332730
DHFR 1719 SULFASALAZINE CHEMBL421 NCI 22555
DHFR 1719 PEMETREXED DISODIUM CHEMBL1200373 inhibitor ChemblInteractions
DHFR 1719 ICLAPRIM CHEMBL134561 binder TTD
DHFR 1719 PERFOSFAMIDE CHEMBL61511 NCI 11162315
DHFR 1719 VITAMIN B12 CHEMBL2375172 NCI 3719892

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
DHFR rs7387 A methotrexate efficacy no but exact variant relationship was not reported. Allele A is associated with response to methotrexate in people with Arthritis, Rheumatoid. 19902562 769173647
DHFR rs70991108 del folic acid efficacy no Allele del is not associated with response to folic acid, hydroxychloroquine, methotrexate and sulfasalazine in people with Arthritis, Rheumatoid. 18322994 769171257
DHFR rs1643650 CC + CT methotrexate efficacy no Those with the CC and CT genotype were more likely to be a responder to treatment. The association was not significant after multiple comparison correction. Genotypes CC + CT is associated with increased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype TT. 25084201 1184748761