PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	HSPA4	3	affinity chromatography technology	Choudhury NR (2017)	1
MOV10	6	POLDIP3	0	affinity chromatography technology	Castello A (2012)	1
NQO1	3	93144	0	biochemical	Havugimana PC (2012)	1
NXF1	0	YTHDF1	1	affinity chromatography technology	Castello A (2012)	1
MOV10	6	HSPA4	3	affinity chromatography technology	Castello A (2012)	1
ADK	0	NQO1	3	biochemical	Wan C (2015)	1
DAZAP1	1	NQO1	3	biochemical	Wan C (2015)	1
LAMB1	10	NQO1	3	biochemical	Havugimana PC (2012)	1
BAG3	4	STUB1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Hein MY (2015)	4
FN1	17	RPS19	1	affinity chromatography technology	Humphries JD (2009)	1
NXF1	0	NQO1	3	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	NDUFS7	1	affinity chromatography technology	Choudhury NR (2017)	1
NXF1	0	GOT1	2	affinity chromatography technology	Castello A (2012)	1
NDUFS7	1	NQO1	3	affinity chromatography technology	Guarani V (2014)	1
STUB1	4	PARP1	3	affinity chromatography technology, affinity chromatography technology	Choi JR (2016), Choi JR (2016)	2
TRIM25	5	DAZAP1	1	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
NQO1	3	NME1	0	biochemical	Wan C (2015)	1
NXF1	0	PARP1	3	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
MOV10	6	STUB1	4	affinity chromatography technology, affinity chromatography technology	Li S (2014), Castello A (2012)	2
MOV10	6	PARP1	3	affinity chromatography technology	Castello A (2012)	1
FN1	17	PARP1	3	affinity chromatography technology	Humphries JD (2009)	1
ITGA4	4	NQO1	3	affinity chromatography technology	Byron A (2012)	1
TP53	0	RPS19	1	affinity chromatography technology	Horikawa I (2014)	1
NXF1	0	STUB1	4	affinity chromatography technology	Castello A (2012)	1
GOT1	2	NME1	0	biochemical	Wan C (2015)	1
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
BAG3	4	PARP1	3	affinity chromatography technology	Chen Y (2013)	1
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
NQO1	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Anwar A (2002), Anwar A (2002)	2
BAG3	4	HSPA4	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2003), Doong H (2003), Gentilella A (2011), Gamerdinger M (2009), Gamerdinger M (2009), Ammirante M (2010), Chen Y (2013), Chen Y (2013)	8
NQO1	3	NQO1	3	x-ray crystallography	Skelly JV (1999)	1
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
FN1	17	ITGA4	4	affinity chromatography technology	Humphries JD (2009)	1
TRIM25	5	NQO1	3	affinity chromatography technology	Choudhury NR (2017)	1
ITGA4	4	PARP1	3	affinity chromatography technology	Byron A (2012)	1
ING1	2	NQO1	3	pull down	Garate M (2008)	1
MOV10	6	NQO1	3	affinity chromatography technology	Castello A (2012)	1
NXF1	0	HSPA4	3	affinity chromatography technology	Castello A (2012)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
TP53	0	NQO1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Asher G (2003), Ahn HJ (2015), Liu K (2015)	3
NXF1	0	BAG3	4	affinity chromatography technology	Castello A (2012)	1
NQO1	3	YTHDF1	1	biochemical	Havugimana PC (2012)	1
TP53	0	YTHDF1	1	affinity chromatography technology	Fogeron ML (2013)	1
NQO1	3	RPS19	1	biochemical	Havugimana PC (2012)	1
UBE2D1	0	FOS	0	enzymatic study	Stancovski I (1995)	1
ITGA4	4	RPS19	1	affinity chromatography technology	Byron A (2012)	1
FN1	17	FUBP3	0	affinity chromatography technology	Humphries JD (2009)	1
ING1	2	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leung KM (2002), Garkavtsev I (1998), Zhu Z (2009)	3
STUB1	4	NQO1	3	enzymatic study, affinity chromatography technology, enzymatic study	Tsvetkov P (2011), Tsvetkov P (2011), Kopp Y (2017)	3
FN1	17	NQO1	3	affinity chromatography technology	Humphries JD (2009)	1
ITGA4	4	FUBP3	0	affinity chromatography technology	Byron A (2012)	1
NQO1	3	POLDIP3	0	biochemical	Havugimana PC (2012)	1
STUB1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Xu Z (2008), Xia T (2007), Jiang J (2001), Graf C (2010), Soss SE (2011), Pabarcus MK (2009), Wang Y (2011), Summers DW (2009), Clapp KM (2010), Wang L (2011), Ren HY (2011), Urushitani M (2004), Plechanovova A (2012), Al-Ramahi I (2006), Germano S (2006), Alberti S (2004), Peng HM (2004), Qian SB (2009), Yang M (2011), Lee H (2006), Windheim M (2008), Tsukahara F (2010), Zhou P (2003), Chymkowitch P (2011), Shimamoto S (2013), Spooner RA (2008), Zhang M (2005), Uchiki T (2009), Wang Y (2011), Wang Y (2015), Narayan V (2015), Clapp KM (2012), Kim HT (2007), McClurg UL (2016), Blessing NA (2017), Landre V (2017), Kopp Y (2017)	37
FN1	17	DAZAP1	1	affinity chromatography technology	Humphries JD (2009)	1
NXF1	0	POLDIP3	0	affinity chromatography technology	Castello A (2012)	1
ITGA4	4	DAZAP1	1	affinity chromatography technology	Byron A (2012)	1
UBE2D1	0	NQO1	3	enzymatic study	Martinez-Limon A (2016)	1
TRIM25	5	RPS19	1	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
DAZAP1	1	ADK	0	biochemical	Wan C (2015)	1
BAG3	4	NQO1	3	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
MOV10	6	GOT1	2	affinity chromatography technology	Castello A (2012)	1
NQO1	3	PARP1	3	affinity chromatography technology	Wu T (2013)	1
FUBP3	0	NQO1	3	biochemical	Wan C (2015)	1
GOT1	2	NQO1	3	biochemical	Wan C (2015)	1
FOS	0	NQO1	3	affinity chromatography technology, biochemical, imaging technique	Adler J (2010), Adler J (2010), Adler J (2010)	3
DAZAP1	1	FUBP3	0	biochemical	Wan C (2015)	1
NQO1	3	NFE2L2	1	affinity chromatography technology	Wu T (2013)	1