PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADGRB1	10	LIN7A	1	unspecified method	Stephenson JR (2013)	1
NTRK1	1	EZR	8	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Schmeiser K (1999), Catimel B (2005), Guo Z (2014)	7
ATP2B2	10	DLG1	2	two hybrid	DeMarco SJ (2001)	1
HUWE1	22	DLG1	2	affinity chromatography technology	Thompson JW (2014)	1
PTEN	24	CDH1	4	affinity chromatography technology	Choi BH (2014)	1
NTRK1	1	CTNNA1	7	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	KIF13B	13	affinity chromatography technology	Emdal KB (2015)	1
DLG1	2	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
CDH1	4	ADAM17	2	bioid	Guo Z (2014)	1
MAPK12	1	DLG1	2	imaging technique	Chen TC (2014)	1
MPP2	0	DLG1	2	affinity chromatography technology	Huttlin EL (2017)	1
KIF26B	11	CASK	18	affinity chromatography technology	Hein MY (2015)	1
PTEN	24	AMOT	6	affinity chromatography technology	Maddika S (2011)	1
PRKN	1	GRIK2	4	affinity chromatography technology	Maraschi A (2014)	1
GRIN2A	13	DLG3	1	two hybrid, affinity chromatography technology, pull down	Irie M (1997), Lim IA (2002), Lim IA (2002)	3
PRKN	1	CAMK2A	6	affinity chromatography technology	Fallon L (2002)	1
DLG3	1	DLGAP1	6	two hybrid	Takeuchi M (1997)	1
CDH1	4	DLG1	2	bioid	Guo Z (2014)	1
DLG1	2	MAP1A	1	affinity chromatography technology	Brenman JE (1998)	1
GRIK2	4	DLG3	1	affinity chromatography technology	Garcia EP (1998)	1
DLG1	2	KIF13B	13	pull down, affinity chromatography technology	Hanada T (2000), Hanada T (2000)	2
KCNJ4	5	LIN7A	1	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ12	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
LRRC1	1	DLG1	2	two hybrid	Saito H (2001)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
AMOT	6	DLG1	2	affinity chromatography technology	Sowa ME (2009)	1
ADGRB1	10	DLG1	2	unspecified method	Stephenson JR (2013)	1
DLG1	2	EPB41	2	pull down	Lue RA (1994)	1
CDH1	4	ATP2B4	5	bioid	Guo Z (2014)	1
TGFA	1	DLG1	2	pull down, two hybrid, affinity chromatography technology, imaging technique	Surena AL (2009), Surena AL (2009), Surena AL (2009), Surena AL (2009)	4
LIN7A	1	GUCY1A2	2	affinity chromatography technology	Hauri S (2013)	1
KCNJ6	6	LRRC1	1	affinity chromatography technology	Huttlin EL (2017)	1
CAMK2A	6	DLG1	2	affinity chromatography technology, enzymatic study	Gardoni F (2003), Gardoni F (2003)	2
LIN7C	0	KIF26B	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
UBE3A	4	DLG1	2	pull down	Matsumoto Y (2006)	1
NTRK1	1	KHDRBS1	1	affinity chromatography technology	Emdal KB (2015)	1
DLG1	2	DLGAP1	6	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, far western blotting	Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Satoh K (1997), Wu H (2000), Wu H (2000), Kim E (1997), Kim E (1997)	8
HNRNPL	3	TJAP1	1	affinity chromatography technology	Fei T (2017)	1
PRKN	1	GRIN2B	30	affinity chromatography technology, imaging technique	Fallon L (2002), Chen TC (2014)	2
NTRK1	1	EPB41	2	affinity chromatography technology	Emdal KB (2015)	1
GUCY1A2	2	DLG1	2	affinity chromatography technology	Russwurm M (2001)	1
ATP2B2	10	DLG3	1	affinity chromatography technology	DeMarco SJ (2001)	1
ACTN2	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Eldstrom J (2003), Eldstrom J (2003)	2
DLG1	2	ADGRA2	4	two hybrid, affinity chromatography technology, pull down	Yamamoto Y (2004), Yamamoto Y (2004), Yamamoto Y (2004)	3
HNRNPL	3	EPB41	2	affinity chromatography technology	Fei T (2017)	1
PRDM1	5	DLG1	2	affinity chromatography technology	Huttlin EL (2017)	1
ATP2B4	5	DLG1	2	pull down	Schuh K (2003)	1
CACNG2	0	GRIA1	5	affinity chromatography technology	Chen L (2001)	1
KCNA3	3	KCNA4	5	affinity chromatography technology	Coleman SK (1999)	1
CDH1	4	EZR	8	affinity chromatography technology, bioid	Hiscox S (1999), Guo Z (2014)	2
ATP2B2	10	ATP2B4	5	affinity chromatography technology	Huttlin EL (2017)	1
KCNJ4	5	CASK	18	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
LIN7C	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
ADAM10	2	DLG1	2	affinity chromatography technology	Marcello E (2007)	1
KCNA3	3	KCNA5	2	fluorescent resonance energy transfe, biochemical, affinity chromatography technology	Vicente R (2008), Vicente R (2008), Huttlin EL (2017)	3
LIN7C	0	APBA1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	3
CTNNA1	7	DLG1	2	affinity chromatography technology	Reuver SM (1998)	1
LIN7C	0	MPP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNJ12	0	DLG3	1	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
KHDRBS1	1	LCK	0	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Fusaki N (1997), Loewenberg M (2006), Tran T (2005), Nervi S (2005)	4
PTEN	24	DLG1	2	pull down	Leslie NR (2001)	1
KCNJ12	0	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
KCNA5	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Godreau D (2003), Mathur R (2006)	2
ACTN2	2	GRIN2B	30	two hybrid, biochemical	Wyszynski M (1997), Wyszynski M (1997)	2
GRIK2	4	GRIA1	5	affinity chromatography technology	Wenthold RJ (1994)	1
KCNC1	3	CAMK2A	6	affinity chromatography technology	El-Haou S (2009)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
DLG1	2	LCK	0	affinity chromatography technology, pull down, imaging technique	Hanada T (1997), Hanada T (1997), Chen TC (2014)	3
CACNG2	0	DLG1	2	affinity chromatography technology	Chen L (2001)	1
KHDRBS1	1	DLG3	1	unspecified method	Asbach B (2012)	1
TMEM17	0	DLG1	2	bioid	Gupta GD (2015)	1
ERBB4	5	DLG3	1	two hybrid	Garcia RA (2000)	1
ERBB4	5	DLG1	2	affinity chromatography technology	Huang YZ (2002)	1
ATP2B4	5	CASK	18	pull down, biochemical	Schuh K (2003), Schuh K (2003)	2
CASK	18	EPB41	2	pull down	Cohen AR (1998)	1
TGFA	1	ADAM17	2	imaging technique, affinity chromatography technology	Chen TC (2014), Surena AL (2009)	2
DLG1	2	KCNJ2	2	pull down	Leonoudakis D (2001)	1
PTPRE	1	DLG1	2	bioid	St-Denis N (2016)	1
KCNJ4	5	LIN7C	0	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
KCNA5	2	ACTN2	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Eldstrom J (2003), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Cukovic D (2001), Cukovic D (2001)	7
KCNA4	5	DLG1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Eldstrom J (2003), Inanobe A (2002), Kim E (1996), Kim E (1995)	4
KCNC1	3	DLG1	2	affinity chromatography technology	El-Haou S (2009)	1
GRIN2B	30	DLG1	2	affinity chromatography technology, two hybrid	Inanobe A (2002), Niethammer M (1996)	2
KCNJ12	0	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
ADAM10	2	LCK	0	affinity chromatography technology	Poghosyan Z (2002)	1
NTRK1	1	UBE3A	4	affinity chromatography technology	Emdal KB (2015)	1
TJAP1	1	DLG1	2	affinity chromatography technology, two hybrid	Kawabe H (2001), Kawabe H (2001)	2
HNRNPL	3	LRRC1	1	affinity chromatography technology	Fei T (2017)	1
ATP2B4	5	DLG3	1	affinity chromatography technology	DeMarco SJ (2001)	1
EZR	8	DLG1	2	pull down	Bonilha VL (2001)	1
TMEM17	0	ATP2B4	5	bioid	Gupta GD (2015)	1
DLG1	2	KCNA3	3	affinity chromatography technology	Hanada T (1997)	1
WWC1	5	LIN7C	0	affinity chromatography technology	Toloczko A (2017)	1
KCNJ4	5	DLG1	2	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001)	3
NTRK1	1	DLG1	2	affinity chromatography technology	Emdal KB (2015)	1
HNRNPL	3	DLG1	2	affinity chromatography technology	Fei T (2017)	1
DLG1	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Hauri S (2013)	3
KHDRBS1	1	DLG1	2	unspecified method	Asbach B (2012)	1
PRKN	1	CASK	18	pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Fallon L (2002), Fallon L (2002), Fallon L (2002), Parelkar SS (2012)	4
DLG1	2	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	4
AMOT	6	LIN7A	1	affinity chromatography technology	Sowa ME (2009)	1
KCNA5	2	ATP2B4	5	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	CASK	18	affinity chromatography technology	Fei T (2017)	1
TMEM17	0	LIN7C	0	bioid	Gupta GD (2015)	1
CDH1	4	EPB41	2	bioid	Guo Z (2014)	1
NTRK1	1	KIF26B	11	affinity chromatography technology	Emdal KB (2015)	1
ADAM17	2	DLG1	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Peiretti F (2003), Peiretti F (2003), Peiretti F (2003), Surena AL (2009), Surena AL (2009), Surena AL (2009), Surena AL (2009)	7
DLG1	2	GRIK2	4	affinity chromatography technology, affinity chromatography technology	Mehta S (2001), Garcia EP (1998)	2
CRIPT	0	DLG1	2	pull down	Cai C (2002)	1
DLG3	1	CAMK2A	6	affinity chromatography technology	Ewing RM (2007)	1
KCNJ6	6	DLG1	2	pull down, pull down	Hibino H (2000), Hibino H (2000)	2
HNRNPL	3	HUWE1	22	affinity chromatography technology	Fei T (2017)	1
DLGAP1	6	GRIN2A	13	affinity chromatography technology	Satoh K (1997)	1
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
WWC1	5	DLG1	2	affinity chromatography technology	Toloczko A (2017)	1
WWC1	5	BTRC	1	affinity chromatography technology	Hauri S (2013)	1
GPRC5B	3	DLG1	2	affinity chromatography technology	Huttlin EL (2017)	1
AMOT	6	WWC1	5	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Toloczko A (2017)	3
LIN7A	1	CASK	18	affinity chromatography technology, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Rolland T (2014), Hauri S (2013)	3
NTRK1	1	HUWE1	22	affinity chromatography technology	Emdal KB (2015)	1
PRKN	1	DLG1	2	imaging technique	Chen TC (2014)	1
GRIN2B	30	LIN7A	1	pull down	Jo K (1999)	1
DLG3	1	GRIN2B	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Sans N (2003), Sans N (2003), Inanobe A (2002), Irie M (1997), Lim IA (2002), Lim IA (2002)	6
AMOT	6	LIN7C	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hauri S (2013)	2
GUCY1A2	2	DLG3	1	affinity chromatography technology	Russwurm M (2001)	1
HNRNPL	3	PTPRE	1	affinity chromatography technology	Fei T (2017)	1
TMEM17	0	CASK	18	bioid	Gupta GD (2015)	1
CAMK2A	6	GRIN2B	30	pull down	Bayer KU (2001)	1
KIF26B	11	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
DLG3	1	CRIPT	0	affinity chromatography technology, pull down	Lim IA (2002), Lim IA (2002)	2
KCNJ12	0	APBA1	6	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
UBE3A	4	LCK	0	two hybrid, pull down	Oda H (1999), Oda H (1999)	2
PRKN	1	AMOT	6	affinity chromatography technology	Zanon A (2013)	1
BTRC	1	CTNNA1	7	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
EFNB3	1	DLG1	2	affinity chromatography technology	Huttlin EL (2017)	1
DLG1	2	BTRC	1	pull down, affinity chromatography technology, affinity chromatography technology	Mantovani F (2003), Mantovani F (2003), Mantovani F (2003)	3
DLG1	2	CASK	18	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Chetkovich DM (2002), Nix SL (2000), Nix SL (2000), Nix SL (2000), Nix SL (2000), So J (2015)	8
APBA1	6	CASK	18	pull down	Borg JP (1999)	1
DLG1	2	MARCH2	2	affinity chromatography technology, affinity chromatography technology	Cao Z (2008), Cao Z (2008)	2
HNRNPL	3	PTEN	24	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	CASK	18	affinity chromatography technology	Emdal KB (2015)	1
GJB7	1	DLG1	2	affinity chromatography technology	Huttlin EL (2017)	1
MPP2	0	LIN7A	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Hauri S (2013), Huttlin EL (2017)	3
HNRNPL	3	GRIK2	4	affinity chromatography technology	Fei T (2017)	1
KCNJ12	0	DLG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001), Leonoudakis D (2001)	6
NET1	1	DLG1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carr HS (2009), Carr HS (2009), Carr HS (2009), Garcia-Mata R (2007)	4
NTRK1	1	MAP1A	1	affinity chromatography technology	Emdal KB (2015)	1
GRIN2A	13	DLG1	2	affinity chromatography technology, pull down, two hybrid	Gardoni F (2003), Gardoni F (2003), Niethammer M (1996)	3
KCNA5	2	KCNA4	5	affinity chromatography technology	Nitabach MN (2001)	1
DLG1	2	GRIA1	5	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gardoni F (2003), Leonard AS (1998), Leonard AS (1998), Sans N (2001)	4