PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DLG3	1	KRT31	0	affinity chromatography technology	Ewing RM (2007)	1
DLG3	1	EXOC4	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003), Sans N (2003), Sans N (2003)	4
ATP2B2	10	DLG1	2	two hybrid	DeMarco SJ (2001)	1
DLG3	1	MRPL22	0	affinity chromatography technology	Hein MY (2015)	1
NLGN3	3	NLGN2	11	affinity chromatography technology	Huttlin EL (2017)	1
DLG4	11	GRIN2C	4	affinity chromatography technology, pull down	Lim IA (2002), Lim IA (2002)	2
APC	5	MRPL18	0	affinity chromatography technology	Hein MY (2015)	1
DLG3	1	ACAD8	0	affinity chromatography technology	Hein MY (2015)	1
DLG4	11	LRP2	13	affinity chromatography technology, two hybrid, two hybrid, pull down	Larsson M (2003), Larsson M (2003), Gotthardt M (2000), Gotthardt M (2000)	4
KHDRBS1	1	DLG4	11	unspecified method	Asbach B (2012)	1
GRIN2A	13	DLG3	1	two hybrid, affinity chromatography technology, pull down	Irie M (1997), Lim IA (2002), Lim IA (2002)	3
ELAVL1	0	NLGN2	11	affinity chromatography technology	Abdelmohsen K (2009)	1
DLG3	1	DLGAP1	6	two hybrid	Takeuchi M (1997)	1
SYNGAP1	65	DLG3	1	two hybrid, affinity chromatography technology	Kim JH (1998), Kim JH (1998)	2
GRIK2	4	DLG3	1	affinity chromatography technology	Garcia EP (1998)	1
BAG3	4	DLG3	1	affinity chromatography technology	Chen Y (2013)	1
DLG3	1	MRPS26	0	affinity chromatography technology	Hein MY (2015)	1
GRIK5	5	DLG3	1	affinity chromatography technology	Garcia EP (1998)	1
CAMK2A	6	DLG1	2	affinity chromatography technology, enzymatic study	Gardoni F (2003), Gardoni F (2003)	2
NLGN3	3	DLG3	1	two hybrid	Irie M (1997)	1
GRIN2B	30	EXOC3	2	affinity chromatography technology	Sans N (2003)	1
GRIN2B	30	EXOC4	2	affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003)	2
ZNF232	1	DLG3	1	affinity chromatography technology	Huttlin EL (2017)	1
KLHDC3	1	RPS6KA4	0	affinity chromatography technology	Huttlin EL (2017)	1
EXOC3	2	EXOC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003), Inoue M (2003), Havugimana PC (2012), Andersen NJ (2010), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
ELAVL1	0	ZFP91	0	affinity chromatography technology	Abdelmohsen K (2009)	1
DLG1	2	DLGAP1	6	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, far western blotting	Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Satoh K (1997), Wu H (2000), Wu H (2000), Kim E (1997), Kim E (1997)	8
ERBB4	5	DLG4	11	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Garcia RA (2000), Huang YZ (2000), Huang YZ (2000), Garcia RA (2000), Garcia RA (2000), Sardi SP (2006), Hahn CG (2006)	7
DLG3	1	MRPL18	0	affinity chromatography technology	Hein MY (2015)	1
GUCY1A2	2	DLG1	2	affinity chromatography technology	Russwurm M (2001)	1
ATP2B2	10	DLG3	1	affinity chromatography technology	DeMarco SJ (2001)	1
DLG3	1	KCTD2	0	affinity chromatography technology	Hein MY (2015)	1
LRP2	13	DLG3	1	two hybrid	Larsson M (2003)	1
DLG3	1	KRT35	0	affinity chromatography technology	Ewing RM (2007)	1
ATP2B4	5	DLG1	2	pull down	Schuh K (2003)	1
GUCY1A2	2	DLG4	11	affinity chromatography technology	Russwurm M (2001)	1
EXOC3	2	EXOC7	3	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Huttlin EL (2017), Boldt K (2016)	3
DLG3	1	GRIN2C	4	affinity chromatography technology, pull down	Lim IA (2002), Lim IA (2002)	2
ATP2B2	10	ATP2B4	5	affinity chromatography technology	Huttlin EL (2017)	1
GRIK2	4	GRIK5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wenthold RJ (1994), Ripellino JA (1998), Valluru L (2005)	3
DLG3	1	SS18L2	0	affinity chromatography technology	Hein MY (2015)	1
GRIN2A	13	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology	Hou XY (2002), Hou XY (2002), Irie M (1997), Irie M (1997), Satoh K (1997), Sans N (2000), Lim IA (2002), Lim IA (2002), Niethammer M (1996), Niethammer M (1996), Papadakis M (2004)	11
GRIK5	5	DLG4	11	affinity chromatography technology, affinity chromatography technology, pull down	Mehta S (2001), Garcia EP (1998), Garcia EP (1998)	3
NLGN3	3	DLG4	11	two hybrid	Irie M (1997)	1
DLG4	11	PTK2B	6	affinity chromatography technology, pull down	Seabold GK (2003), Seabold GK (2003)	2
KCNJ12	0	DLG3	1	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
DLG3	1	APC	5	pull down, two hybrid	Makino K (1997), Makino K (1997)	2
NLGN3	3	NLGN1	5	affinity chromatography technology	Huttlin EL (2017)	1
DLG3	1	ARFGAP1	3	biochemical	Wan C (2015)	1
DLG3	1	RPS6KA4	0	biochemical	Wan C (2015)	1
KHDRBS1	1	DLG3	1	unspecified method	Asbach B (2012)	1
DLG3	1	GDA	1	affinity chromatography technology, pull down	Kuwahara H (1999), Kuwahara H (1999)	2
DLG3	1	KRT85	5	affinity chromatography technology	Ewing RM (2007)	1
NLGN1	5	DLG4	11	two hybrid, pull down	Irie M (1997), Irie M (1997)	2
DLG3	1	PTK2B	6	affinity chromatography technology, affinity chromatography technology, pull down	Seabold GK (2003), Seabold GK (2003), Seabold GK (2003)	3
ERBB4	5	DLG3	1	two hybrid	Garcia RA (2000)	1
DLG3	1	COBLL1	3	affinity chromatography technology	Hein MY (2015)	1
ERBB4	5	DLG1	2	affinity chromatography technology	Huang YZ (2002)	1
EXOC7	3	GRIN2B	30	pull down	Sans N (2003)	1
NLGN1	5	DLG3	1	two hybrid	Irie M (1997)	1
CRIPT	0	DLG4	11	pull down	Niethammer M (1998)	1
CNPY2	2	DLG3	1	affinity chromatography technology	Huttlin EL (2017)	1
GRIN2B	30	DLG1	2	affinity chromatography technology, two hybrid	Inanobe A (2002), Niethammer M (1996)	2
DLG3	1	WDR91	2	affinity chromatography technology	Hein MY (2015)	1
KLHDC3	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
GRIN2A	13	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Seabold GK (2003), Liu Y (2001)	2
DLGAP1	6	DLG4	11	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Takeuchi M (1997), Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Boeckers TM (1999), Wu H (2000), Kim E (1997), Kim E (1997), Kim E (1997), Kim E (1997)	11
ATP2B4	5	DLG3	1	affinity chromatography technology	DeMarco SJ (2001)	1
APC	5	ZFP91	0	affinity chromatography technology	Novellasdemunt L (2017)	1
NLGN2	11	DLG3	1	two hybrid	Irie M (1997)	1
DLG3	1	HIST1H2BC	0	affinity chromatography technology	Ewing RM (2007)	1
SEMA4C	5	DLG4	11	two hybrid, affinity chromatography technology, pull down	Inagaki S (2001), Inagaki S (2001), Inagaki S (2001)	3
ELAVL1	0	CRIPT	0	affinity chromatography technology	Abdelmohsen K (2009)	1
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
SEMA4C	5	DLG3	1	two hybrid	Inagaki S (2001)	1
KHDRBS1	1	DLG1	2	unspecified method	Asbach B (2012)	1
TEAD4	1	DLG3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DLG1	2	GRIK2	4	affinity chromatography technology, affinity chromatography technology	Mehta S (2001), Garcia EP (1998)	2
KRT31	0	SEMA4C	5	two hybrid	Rolland T (2014)	1
SYNGAP1	65	DLG4	11	two hybrid	Kim JH (1998)	1
CRIPT	0	DLG1	2	pull down	Cai C (2002)	1
DLG3	1	CAMK2A	6	affinity chromatography technology	Ewing RM (2007)	1
DLG3	1	S100A3	1	affinity chromatography technology	Ewing RM (2007)	1
DLG3	1	KRT82	7	affinity chromatography technology	Ewing RM (2007)	1
NLGN2	11	DLG4	11	two hybrid	Irie M (1997)	1
DLG3	1	KLHDC3	1	affinity chromatography technology	Ewing RM (2007)	1
DLG3	1	ANXA1	1	affinity chromatography technology	Ewing RM (2007)	1
GRIK2	4	DLG4	11	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Hirbec H (2003), Hirbec H (2003), Mehta S (2001), Garcia EP (1998), Garcia EP (1998), Piserchio A (2002)	6
EXOC7	3	DLG3	1	pull down	Sans N (2003)	1
DLGAP1	6	GRIN2A	13	affinity chromatography technology	Satoh K (1997)	1
CUL2	3	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
BAG3	4	ANXA1	1	affinity chromatography technology	Chen Y (2013)	1
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
EXOC4	2	DLG4	11	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sans N (2003), Riefler GM (2003), Riefler GM (2003), Riefler GM (2003)	4
EXOC7	3	EXOC4	2	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sans N (2003), Inoue M (2003), Havugimana PC (2012), Bodemann BO (2011), Wan C (2015), Boldt K (2016)	6
DLG3	1	AP3B1	3	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	DLG3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
APC	5	DLGAP1	6	affinity chromatography technology	Satoh K (1997)	1
ELAVL1	0	DLG4	11	affinity chromatography technology	Abdelmohsen K (2009)	1
DLG3	1	GRIN2B	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Sans N (2003), Sans N (2003), Inanobe A (2002), Irie M (1997), Lim IA (2002), Lim IA (2002)	6
GUCY1A2	2	DLG3	1	affinity chromatography technology	Russwurm M (2001)	1
CAMK2A	6	GRIN2B	30	pull down	Bayer KU (2001)	1
DLG3	1	CRIPT	0	affinity chromatography technology, pull down	Lim IA (2002), Lim IA (2002)	2
RACGAP1	2	DLG3	1	affinity chromatography technology	Hein MY (2015)	1
DLG3	1	KRT34	6	affinity chromatography technology	Ewing RM (2007)	1
RB1CC1	9	PTK2B	6	affinity chromatography technology, pull down, two hybrid, genetic interference	Ueda H (2000), Ueda H (2000), Ueda H (2000), Ueda H (2000)	4
KCNJ12	0	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
GRIN2B	30	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down	Sans N (2003), Inanobe A (2002), Irie M (1997), Niethammer M (1998), Lim IA (2002), Kornau HC (1995), Kornau HC (1995), Niethammer M (1996), Niethammer M (1996), Imamura F (2002)	10
EXOC3	2	DLG3	1	affinity chromatography technology, affinity chromatography technology	Sans N (2003), Sans N (2003)	2
DLG3	1	ZFP91	0	affinity chromatography technology	Hein MY (2015)	1
KCNJ12	0	DLG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001), Leonoudakis D (2001)	6
DLG3	1	RB1CC1	9	affinity chromatography technology	Hein MY (2015)	1
GRIN2A	13	DLG1	2	affinity chromatography technology, pull down, two hybrid	Gardoni F (2003), Gardoni F (2003), Niethammer M (1996)	3
RHBDL1	4	DLG3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DLG3	1	CUL2	3	affinity chromatography technology	Ewing RM (2007)	1