PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATXN1	2	DMPK	3	two hybrid	Lim J (2006)	1
UBQLN4	2	PIN1	0	two hybrid	Lim J (2006)	1
TK1	0	DMPK	3	two hybrid	Vinayagam A (2011)	1
HSPB2	1	DMPK	3	two hybrid, affinity chromatography technology, pull down, two hybrid	Suzuki A (1998), Suzuki A (1998), Suzuki A (1998), Sugiyama Y (2000)	4
RAC1	7	DMPK	3	pull down, pull down	Shimizu M (2000), Shimizu M (2000)	2
DMPK	3	GEMIN4	2	two hybrid	Wang J (2011)	1
SMN1	0	DMPK	3	two hybrid	Vinayagam A (2011)	1
RPS10	0	DMPK	3	two hybrid	Vinayagam A (2011)	1
LGR4	3	DMPK	3	affinity chromatography technology	Carmon KS (2014)	1
SMN1	0	GEMIN4	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carnegie GK (2003), Meister G (2000), Meister G (2000), Fuller HR (2010), Piazzon N (2012), Joshi P (2013), Han KJ (2016)	7
ANXA7	0	DMPK	3	two hybrid	Vinayagam A (2011)	1
DMPK	3	HOXA2	1	two hybrid	Corominas R (2014)	1
PIN1	0	DMPK	3	two hybrid	Vinayagam A (2011)	1
ATN1	2	DMPK	3	two hybrid	Lim J (2006)	1
UBQLN4	2	DMPK	3	two hybrid	Lim J (2006)	1
HSP90AA1	7	DMPK	3	affinity chromatography technology	Taipale M (2012)	1
PLN	1	DMPK	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kaliman P (2005), Kaliman P (2005), Kaliman P (2005)	3
ATXN1	2	UBQLN4	2	two hybrid, two hybrid	Davidson JD (2000), Lim J (2006)	2