PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DCTN1	6	PAFAH1B1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Tai CY (2002), Faulkner NE (2000), Faulkner NE (2000), Gupta GD (2015), Boldt K (2016)	5
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
DYNC1I1	1	DYNLT1	3	two hybrid	Diefenbach RJ (2002)	1
STAU1	1	TUBB3	3	affinity chromatography technology	Brendel C (2004)	1
100506627	0	DCTN1	6	affinity chromatography technology, affinity chromatography technology	Kaplan A (2011), Kaplan A (2011)	2
DYNC1I1	1	MCC	3	two hybrid	Vinayagam A (2011)	1
DNM2	2	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
DYNC1I1	1	AMBRA1	7	affinity chromatography technology	Di Bartolomeo S (2010)	1
DYNLRB1	1	DYNC1LI1	1	biochemical	Kristensen AR (2012)	1
DYNC1I1	1	DYNLT3	1	two hybrid	Diefenbach RJ (2002)	1
TK1	0	TUBB3	3	two hybrid	Vinayagam A (2011)	1
EMILIN1	1	DYNC1I1	1	pull down	Ban KH (2007)	1
BICD2	0	PAFAH1B1	3	affinity chromatography technology	Splinter D (2012)	1
DISC1	6	DYNC1H1	41	two hybrid	Camargo LM (2007)	1
DYNC1I2	0	PAFAH1B1	3	affinity chromatography technology	Boldt K (2016)	1
CUL3	17	DYNC1I2	0	affinity chromatography technology	Bennett EJ (2010)	1
DYNC1I1	1	DYNLRB1	1	two hybrid	Rual JF (2005)	1
CUL3	17	TUBB3	3	affinity chromatography technology	Bennett EJ (2010)	1
DYNC1LI1	1	DCTN1	6	affinity chromatography technology	Splinter D (2012)	1
DCTN1	6	FAM83D	1	bioid	Gupta GD (2015)	1
TRIM58	1	DYNC1I1	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Thom CS (2014), Thom CS (2014), Thom CS (2014), Thom CS (2014)	4
DCTN2	0	BICD2	0	two hybrid, pull down, affinity chromatography technology	Hoogenraad CC (2001), Hoogenraad CC (2001), Splinter D (2012)	3
DYNC1I1	1	WDCP	2	two hybrid	Vinayagam A (2011)	1
SMN1	0	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
DYNC1LI1	1	PAFAH1B1	3	affinity chromatography technology	Boldt K (2016)	1
NAGK	4	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
NUDT21	0	RCC1	2	two hybrid	Vinayagam A (2011)	1
DYNLL1	0	DYNC1I1	1	two hybrid, two hybrid, pull down, unspecified method, affinity chromatography technology	Diefenbach RJ (2002), Diefenbach RJ (2002), Lo KW (2001), Lo KW (2001), Di Bartolomeo S (2010)	5
DISC1	6	NDEL1	2	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Morris JA (2003), Morris JA (2003), Ozeki Y (2003), Ozeki Y (2003), Ozeki Y (2003), Park YU (2010), Camargo LM (2007), Brandon NJ (2004), Brandon NJ (2004), Huttlin EL (2017)	10
RCC1	2	TUBB3	3	two hybrid	Vinayagam A (2011)	1
DYNC1I1	1	CADM4	0	two hybrid	Vinayagam A (2011)	1
DYNC1LI2	2	DYNC1I2	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	3
DCTN2	0	KCNA5	2	affinity chromatography technology	Choi WS (2005)	1
DYNC1I1	1	DYNC1LI2	2	affinity chromatography technology	Huttlin EL (2017)	1
DYNC1I1	1	100506627	0	pull down, affinity chromatography technology, affinity chromatography technology	Kaplan A (2011), Kaplan A (2011), Kaplan A (2011)	3
RCC1	2	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
DYNLL1	0	DYNLT1	3	affinity chromatography technology	Boldt K (2016)	1
NUDT21	0	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
PAFAH1B1	3	DYNLL1	0	affinity chromatography technology, affinity chromatography technology	Faulkner NE (2000), Faulkner NE (2000)	2
DYNC1I1	1	DYNC1I2	0	affinity chromatography technology	Huttlin EL (2017)	1
DYNC1H1	41	DYNLT1	3	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Gupta GD (2015), Boldt K (2016)	4
DYNC1I1	1	DISC1	6	affinity chromatography technology	Huttlin EL (2017)	1
BICD2	0	DYNC1I1	1	affinity chromatography technology, affinity chromatography technology	Hoogenraad CC (2001), Splinter D (2012)	2
CUL3	17	STAU1	1	affinity chromatography technology	Bennett EJ (2010)	1
STAU1	1	DYNC1I1	1	affinity chromatography technology	Brendel C (2004)	1
EMILIN1	1	WDCP	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM58	1	DYNC1H1	41	affinity chromatography technology, affinity chromatography technology	Thom CS (2014), Thom CS (2014)	2
DYNLRB1	1	DYNLT1	3	biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Gupta GD (2015), Boldt K (2016)	3
DYNLRB1	1	DYNLL1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
NDEL1	2	DYNC1I1	1	affinity chromatography technology, pull down	Liang Y (2004), Kaplan A (2011)	2
DYNC1I2	0	DCTN1	6	biochemical, bioid	Wan C (2015), Gupta GD (2015)	2
PIN1	0	EP300	36	pull down	Yi P (2005)	1
NDEL1	2	DCTN2	0	affinity chromatography technology	Liang Y (2004)	1
DYNC1LI2	2	DYNC1H1	41	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	4
CUL3	17	DYNC1I1	1	affinity chromatography technology	Bennett EJ (2010)	1
DISC1	6	PAFAH1B1	3	two hybrid	Camargo LM (2007)	1
DYNLT3	1	PAFAH1B1	3	affinity chromatography technology	Boldt K (2016)	1
GRB7	1	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
DCTN1	6	DYNC1H1	41	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, bioid, affinity chromatography technology	Payne C (2003), Havugimana PC (2012), Splinter D (2012), Wan C (2015), Gupta GD (2015), Hein MY (2015)	6
DYNC1I1	1	PAFAH1B1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamada M (2008), Murdoch H (2011), Murdoch H (2011), Ding C (2009)	4
DYNLL1	0	DYNC1I2	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Hein MY (2015)	2
DYNC1H1	41	DYNC1I1	1	affinity chromatography technology, affinity chromatography technology	Splinter D (2012), Huttlin EL (2017)	2
100506627	0	PAFAH1B1	3	affinity chromatography technology	Kaplan A (2011)	1
DYNC1I1	1	DYNLL2	0	two hybrid	Rual JF (2005)	1
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
DYNC1I1	1	KAT7	3	two hybrid	Vinayagam A (2011)	1
DYNC1I1	1	FBP1	2	two hybrid	Vinayagam A (2011)	1
BECN1	2	AMBRA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Strappazzon F (2011), Xia P (2013), Xia P (2013), Xia P (2013), Luciani A (2010), Luciani A (2010), Di Bartolomeo S (2010), Gu W (2014), Gu W (2014), Antonioli M (2014)	11
DYNC1LI1	1	DYNC1I1	1	affinity chromatography technology, affinity chromatography technology	Splinter D (2012), Huttlin EL (2017)	2
ANXA7	0	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
DYNC1I1	1	RAP1GAP	4	two hybrid	Vinayagam A (2011)	1
DYNC1I1	1	TUBB3	3	affinity chromatography technology	Yamada M (2008)	1
PAFAH1B1	3	DCTN2	0	two hybrid	Tai CY (2002)	1
CUL3	17	DYNC1H1	41	affinity chromatography technology	Bennett EJ (2010)	1
DCTN2	0	DYNC1H1	41	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
DYNLL1	0	DYNC1LI1	1	affinity chromatography technology	Hein MY (2015)	1
DYNLT1	3	WDCP	2	bioid	Gupta GD (2015)	1
WDR34	2	DYNLRB1	1	affinity chromatography technology	Boldt K (2016)	1
DYNLRB1	1	DYNC1LI2	2	biochemical	Kristensen AR (2012)	1
KIAA0368	0	DCTN1	6	imaging technique	Gorbea C (2010)	1
DYNC1I1	1	DCTN1	6	two hybrid, affinity chromatography technology	Vinayagam A (2011), Splinter D (2012)	2
DYNC1I2	0	DYNLT3	1	two hybrid	Rual JF (2005)	1
DYNLT1	3	WDR34	2	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
DYNC1LI1	1	DYNC1I2	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	3
SMN1	0	TUBB3	3	two hybrid	Vinayagam A (2011)	1
STAU1	1	NUDT21	0	affinity chromatography technology	Milev MP (2012)	1
DYNC1LI1	1	BICD2	0	affinity chromatography technology	Splinter D (2012)	1
DCTN1	6	DCTN2	0	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Splinter D (2012), Huttlin EL (2015), Wan C (2015), Gupta GD (2015), Huttlin EL (2017), Boldt K (2016)	7
DYNLL1	0	FAM83D	1	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	DCTN2	0	affinity chromatography technology	Bennett EJ (2010)	1
DYNC1LI1	1	DYNC1H1	41	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
AMBRA1	7	TUBB3	3	affinity chromatography technology	Antonioli M (2014)	1
TK1	0	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
CUL3	17	RPL23	0	affinity chromatography technology	Bennett EJ (2010)	1
PAFAH1B1	3	DYNC1H1	41	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Tai CY (2002), Tai CY (2002), Tai CY (2002), Ding C (2009), Yamada M (2008), Caspi M (2003), Wan C (2015), Hein MY (2015), Boldt K (2016)	9
CUL3	17	DYNC1LI1	1	affinity chromatography technology	Bennett EJ (2010)	1
DYNC1I1	1	FAM83D	1	two hybrid, affinity chromatography technology	Vinayagam A (2011), Huttlin EL (2017)	2
DYNC1I1	1	RUNDC3B	4	two hybrid	Vinayagam A (2011)	1
TRIM58	1	DYNC1LI2	2	affinity chromatography technology	Thom CS (2014)	1
DYNLT1	3	DYNLT3	1	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	WDR34	2	affinity chromatography technology	Boldt K (2016)	1
EP300	36	DYNC1I1	1	affinity chromatography technology	Kirilyuk A (2012)	1
DCTN1	6	DYNLL1	0	affinity chromatography technology	Faulkner NE (2000)	1
CUL3	17	SMN1	0	affinity chromatography technology	Bennett EJ (2010)	1
BICD2	0	DYNC1H1	41	affinity chromatography technology, affinity chromatography technology	Hoogenraad CC (2001), Splinter D (2012)	2
DYNC1I1	1	RPL23	0	affinity chromatography technology	Huttlin EL (2017)	1
DYNLL2	0	DYNC1I2	0	affinity chromatography technology	Boldt K (2016)	1
DYNLT1	3	DYNC1I2	0	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
DYNC1LI2	2	DYNLT1	3	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Gupta GD (2015), Boldt K (2016)	4
DISC1	6	DCTN1	6	two hybrid	Camargo LM (2007)	1
STAU1	1	DNM2	2	affinity chromatography technology	Milev MP (2012)	1
DYNC1I1	1	BECN1	2	affinity chromatography technology	Di Bartolomeo S (2010)	1
DYNLRB1	1	DYNC1I2	0	biochemical, two hybrid	Kristensen AR (2012), Rolland T (2014)	2
NDEL1	2	PAFAH1B1	3	two hybrid, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Toyo-oka K (2003), Toyo-oka K (2003), Niethammer M (2000), Niethammer M (2000), Niethammer M (2000), Ding C (2009), Liang Y (2004), Caspi M (2003), Caspi M (2003), Caspi M (2003), Huttlin EL (2017), Boldt K (2016)	12
BECN1	2	DYNLL1	0	affinity chromatography technology	Di Bartolomeo S (2010)	1
CDKN1A	1	TUBB3	3	two hybrid	Vinayagam A (2011)	1
DYNC1I1	1	KLC3	3	affinity chromatography technology	Yamada M (2008)	1
DYNLT1	3	DCTN1	6	bioid	Gupta GD (2015)	1
DYNLT1	3	PAFAH1B1	3	affinity chromatography technology	Boldt K (2016)	1
DYNC1I1	1	WDR34	2	affinity chromatography technology	Huttlin EL (2017)	1
DYNLL2	0	AMBRA1	7	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	DYNC1H1	41	affinity chromatography technology	Hein MY (2015)	1
DYNC1LI1	1	DYNLT1	3	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Gupta GD (2015), Boldt K (2016)	4
DYNLT1	3	NDEL1	2	bioid	Gupta GD (2015)	1
DCTN2	0	DYNLRB1	1	biochemical	Havugimana PC (2012)	1
DYNC1H1	41	DYNLT3	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
DYNLL2	0	DYNLT1	3	affinity chromatography technology	Boldt K (2016)	1
PIN1	0	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
NDEL1	2	DYNC1H1	41	affinity chromatography technology, biochemical, affinity chromatography technology	Niethammer M (2000), Yamada M (2008), Liang Y (2004)	3
DYNC1I1	1	FAM110A	0	two hybrid	Vinayagam A (2011)	1
DCTN1	6	BICD2	0	affinity chromatography technology	Splinter D (2012)	1
CUL3	17	DYNC1LI2	2	affinity chromatography technology	Bennett EJ (2010)	1
DISC1	6	DCTN2	0	two hybrid	Camargo LM (2007)	1
DCTN2	0	DYNC1I1	1	affinity chromatography technology	Splinter D (2012)	1
DYNC1LI1	1	DYNC1LI2	2	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
DYNLL1	0	WDR34	2	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
EMILIN1	1	DCTN2	0	pull down, imaging technique	Ban KH (2007), Ban KH (2007)	2
CDKN1A	1	DYNC1I1	1	two hybrid	Vinayagam A (2011)	1
CUL3	17	DCTN1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DYNLRB1	1	affinity chromatography technology	Bennett EJ (2010)	1
DCTN1	6	DNM2	2	bioid	Gupta GD (2015)	1
KIAA0368	0	DYNC1I1	1	imaging technique	Gorbea C (2010)	1
DYNC1I1	1	90378	0	affinity chromatography technology	Huttlin EL (2017)	1
ANXA7	0	TUBB3	3	two hybrid	Vinayagam A (2011)	1
DYNC1LI2	2	DYNLL1	0	biochemical, affinity chromatography technology	Kristensen AR (2012), Hein MY (2015)	2
AMBRA1	7	DYNLL1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Di Bartolomeo S (2010), Di Bartolomeo S (2010), Boldt K (2016)	3
CUL3	17	DYNLT1	3	affinity chromatography technology	Bennett EJ (2010)	1
DYNC1I1	1	TAOK1	5	two hybrid	Vinayagam A (2011)	1
DYNC1LI2	2	DYNLT3	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
DYNC1LI1	1	DYNLT3	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
DYNC1I1	1	C15orf39	0	affinity chromatography technology	Huttlin EL (2017)	1
DYNLRB1	1	DYNC1H1	41	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
DYNC1I1	1	KCNA5	2	affinity chromatography technology	Choi WS (2005)	1
EMILIN1	1	RPL23	0	affinity chromatography technology	Huttlin EL (2017)	1
DYNC1I2	0	DYNC1H1	41	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
DYNC1I1	1	MGA	9	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	NUDT21	0	affinity chromatography technology	Bennett EJ (2010)	1