PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRDMT1	1	APP	1	pull down	Olah J (2011)	1
DDX24	1	TRDMT1	1	two hybrid	Stelzl U (2005)	1
TRDMT1	1	COPS6	0	two hybrid	Stelzl U (2005)	1
PPP1R12A	6	TRDMT1	1	affinity chromatography technology	Yadav L (2017)	1
TRDMT1	1	UTP14A	0	two hybrid	Stelzl U (2005)	1
TRDMT1	1	RBM48	1	two hybrid	Stelzl U (2005)	1
PPP1R16B	2	TRDMT1	1	affinity chromatography technology	Yadav L (2017)	1
TBC1D2B	3	TRDMT1	1	two hybrid	Wang J (2011)	1
TRDMT1	1	UNC119	4	two hybrid	Stelzl U (2005)	1
SNRPD3	0	TRDMT1	1	two hybrid	Wang J (2011)	1
TRDMT1	1	EEF1A1	0	two hybrid	Stelzl U (2005)	1
TRDMT1	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
TRDMT1	1	SETDB1	3	two hybrid	Stelzl U (2005)	1
GBE1	0	TRDMT1	1	two hybrid	Wang J (2011)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
APP	1	UTP14A	0	pull down	Virok DP (2011)	1
NFRKB	4	TRDMT1	1	two hybrid	Wang J (2011)	1
TRDMT1	1	STX1A	2	two hybrid	Stelzl U (2005)	1