PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
INPP5D	2	LYN	2	affinity chromatography technology, pull down	Baran CP (2003), Baran CP (2003)	2
EGFR	5	RASA1	3	pull down, unspecified method, pull down	Daly RJ (1996), Jones RB (2006), Marengere LE (1992)	3
KIT	4	PIK3R1	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	De Sepulveda P (1999), van Dijk TB (2000), Serve H (1994), Zhu MJ (2007), Zhu MJ (2007), Yokouchi M (1997), Chen TC (2014)	7
LYN	2	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down	Liang X (2002), Linnekin D (1997), Linnekin D (1997)	3
ERBB2	6	ITK	7	unspecified method	Jones RB (2006)	1
RASA1	3	DOK2	2	affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Di Cristofano A (1998)	2
DOK1	2	SRC	2	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
SRC	2	CBLL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan G (2011), Shen Y (2008), Shrestha H (2017)	3
BCR	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2000), Million RP (2004), Million RP (2004), Puil L (1994), Puil L (1994), Ma G (1997), Maru Y (1995), Maru Y (1995), Gaston I (2004), Gaston I (2004), Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	13
ERBB2	6	CRK	0	unspecified method	Jones RB (2006)	1
DOK1	2	DOK3	5	two hybrid	Grossmann A (2015)	1
CRK	0	ABL2	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, two hybrid	Brehme M (2009), Feller SM (1994), Feller SM (1994), Hu H (2005), Grossmann A (2015)	5
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
PLCG1	6	RET	3	pull down, imaging technique	Borrello MG (1996), Chen TC (2014)	2
TEC	2	KIT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	van Dijk TB (2000), Tang B (1994), Tang B (1994), Tang B (1994)	4
SRC	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Burnham MR (1999), Song JJ (2010), Liu W (2010), Chen TC (2014)	4
EGFR	5	CRKL	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
DOK1	2	ITGB3	6	pull down	Anthis NJ (2009)	1
CBLL1	6	DOK1	2	affinity chromatography technology	Mukherjee M (2012)	1
ERBB2	6	DOK1	2	unspecified method	Jones RB (2006)	1
ABL2	4	GRB2	2	pull down	Feller SM (1994)	1
DOK1	2	TLN1	5	pull down	Anthis NJ (2009)	1
ERBB2	6	ITGB1	4	affinity chromatography technology	Ritch PA (2003)	1
ERBB2	6	FGR	1	unspecified method	Jones RB (2006)	1
DOK2	2	CRKL	1	two hybrid	Grossmann A (2015)	1
EGFR	5	YES1	1	affinity chromatography technology	Tong J (2014)	1
ABL1	9	PLCG1	6	pull down	Koch A (2000)	1
NCK1	0	SH2D1A	0	two hybrid	Grossmann A (2015)	1
NCK2	2	ERBB2	6	unspecified method	Jones RB (2006)	1
BCR	3	ABL1	9	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Ling X (2003), Pendergast AM (1991), Puil L (1994), Puil L (1994), Slupianek A (2011)	5
VAV1	2	ABL1	9	pull down, two hybrid, affinity chromatography technology, enzymatic study	Bassermann F (2002), Bassermann F (2002), Bassermann F (2002), Bassermann F (2002)	4
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
DOK1	2	ABL2	4	unspecified method	Liu BA (2012)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
SHC1	0	TEC	2	affinity chromatography technology	Brehme M (2009)	1
DOK1	2	PLCG1	6	pull down	van Dijk TB (2000)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
ABL1	9	DOK2	2	enzymatic study	Di Cristofano A (1998)	1
CRK	0	DOK2	2	two hybrid	Grossmann A (2015)	1
SHC1	0	BCR	3	affinity chromatography technology	Brehme M (2009)	1
CRK	0	RET	3	pull down, imaging technique	Bocciardi R (1997), Chen TC (2014)	2
SRC	2	RET	3	affinity chromatography technology	Melillo RM (1999)	1
DOK1	2	ITGB7	9	pull down	Anthis NJ (2009)	1
GRB2	2	TEC	2	affinity chromatography technology	Bisson N (2011)	1
DOK1	2	YES1	1	pull down	van Dijk TB (2000)	1
PIK3R1	6	INPP5D	2	affinity chromatography technology	Zhang S (1999)	1
NCK1	0	INPP5D	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
VAV1	2	INSR	9	pull down	Uddin S (1995)	1
EGFR	5	DOK1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
SHC1	0	DOK1	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Dunant NM (2000), Dunant NM (2000), Liu BA (2012)	3
SHC1	0	DOK2	2	affinity chromatography technology	Dunant NM (2000)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
CRK	0	BCR	3	pull down, affinity chromatography technology	Ingham RJ (1996), Brehme M (2009)	2
DOK1	2	CRKL	1	pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, two hybrid	van Dijk TB (2000), Bhat A (1998), Bhat A (1998), Bhat A (1998), Bhat A (1998), Martelli MP (2001), Grossmann A (2015)	7
GRB2	2	DOK3	5	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
TEC	2	LYN	2	affinity chromatography technology	van Dijk TB (2000)	1
PLCG1	6	ERBB2	6	affinity chromatography technology, biochemical, unspecified method	Peles E (1991), Arteaga CL (1991), Jones RB (2006)	3
DOK2	2	DOK3	5	two hybrid	Grossmann A (2015)	1
ABL1	9	HCK	5	affinity chromatography technology	Warmuth M (1997)	1
PLCG1	6	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jabado N (1998), Jabado N (1997), Jabado N (1997)	3
DOK1	2	ITK	7	unspecified method	Liu BA (2012)	1
RASA1	3	ABL1	9	affinity chromatography technology	Druker B (1992)	1
INSR	9	SHC1	0	two hybrid, pull down	Kasus-Jacobi A (2000), Wolf G (1995)	2
DOK2	2	PLCG1	6	affinity chromatography technology	Huttlin EL (2017)	1
LYN	2	DOK1	2	enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	3
INPP5D	2	DOK2	2	affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000)	2
ERBB2	6	TEC	2	unspecified method	Jones RB (2006)	1
RASA1	3	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, pull down, affinity chromatography technology	Holland SJ (1997), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011)	7
SHC1	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Puil L (1994), Brehme M (2009), Brehme M (2009), Brehme M (2009)	5
EGFR	5	ITGB1	4	fluorescent resonance energy transfe	Petras M (2013)	1
VAV1	2	EGFR	5	affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Moores SL (2000), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	4
CRKL	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down	Gesbert F (1998), Gelkop S (2001), Ren SY (2005)	3
VAV1	2	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Bertagnolo V (1998), Bertagnolo V (1998), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
ABL1	9	ABL2	4	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Cao C (2003), Cao C (2003), Cao C (2003), Cao C (2005)	4
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
NCK1	0	PIK3R1	6	affinity chromatography technology	Gelkop S (2001)	1
DOK2	2	RET	3	affinity chromatography technology	Grimm J (2001)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
EGFR	5	TLN1	5	unspecified method	Jones RB (2006)	1
KIT	4	GRB2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	De Sepulveda P (1999), Thoemmes K (1999), Feng GS (1996), Sun J (2007), Zhu MJ (2007), Wollberg P (2003), Brizzi MF (1996)	7
ITGB1	4	SHC1	0	affinity chromatography technology	Lee DY (2010)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
ITK	7	PLCG1	6	pull down, affinity chromatography technology, enzymatic study	Perez-Villar JJ (1999), Perez-Villar JJ (1999), Hao S (2002)	3
KIT	4	CRK	0	two hybrid	Yokouchi M (1997)	1
KIT	4	INPP5D	2	pull down	van Dijk TB (2000)	1
NCK2	2	NCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
ERBB2	6	VAV1	2	unspecified method	Jones RB (2006)	1
PIK3R1	6	RET	3	pull down	Besset V (2000)	1
DOK2	2	EGFR	5	pull down	Jones N (1999)	1
LYN	2	SH2D1A	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2013), Zhu J (2013)	2
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
ABL1	9	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, two hybrid, enzymatic study	Brehme M (2009), Brehme M (2009), Brehme M (2009), Peterson ME (2008), Yoshida K (2005), Chen C (2008), Feller SM (1994), Feller SM (1994), Bai RY (1998), Ren J (2002)	10
YES1	1	FGR	1	affinity chromatography technology	Huttlin EL (2017)	1
TLN1	5	ITGB7	9	pull down	Anthis NJ (2009)	1
KIT	4	YES1	1	pull down	van Dijk TB (2000)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
ITK	7	SRC	2	pull down	Bunnell SC (2000)	1
DOK1	2	BCR	3	affinity chromatography technology, affinity chromatography technology, pull down	Bhat A (1998), Bhat A (1998), Bhat A (1998)	3
GRB2	2	CD28	0	pull down, pull down	Okkenhaug K (1998), Nunes JA (1996)	2
EGFR	5	FGR	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
EGFR	5	PTK6	1	affinity chromatography technology, unspecified method	Kamalati T (1996), Jones RB (2006)	2
PTK6	1	ERBB2	6	affinity chromatography technology, affinity chromatography technology	Xiang B (2008), Xiang B (2008)	2
TLN1	5	ITGB3	6	pull down, pull down, pull down, pull down, pull down	Patil S (1999), Calderwood DA (2002), Calderwood DA (2002), Anthis NJ (2009), Ulmer TS (2001)	5
COLGALT2	2	DOK1	2	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	KIT	4	unspecified method	Wollberg P (2003)	1
NCK2	2	ABL2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITGB1	4	TLN1	5	unspecified method, biochemical, pull down, pull down	Martel V (2001), Havugimana PC (2012), Anthis NJ (2009), Anthis NJ (2009)	4
CRKL	1	SHC1	0	affinity chromatography technology	Chin H (1997)	1
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
DOK1	2	FGR	1	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
SH2D1A	0	DOK1	2	pull down, affinity chromatography technology	Sylla BS (2000), Sylla BS (2000)	2
DOK1	2	NCK1	0	unspecified method, affinity chromatography technology	Liu BA (2012), Wick MJ (2001)	2
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
NCK2	2	DOK1	2	pull down, affinity chromatography technology, affinity chromatography technology	Chen M (1998), Huttlin EL (2015), Huttlin EL (2017)	3
HCK	5	SRC	2	affinity chromatography technology	Howlett CJ (2002)	1
EGFR	5	ABL2	4	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
ABL2	4	HCK	5	two hybrid	Wang J (2011)	1
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
DOK2	2	NCK2	2	affinity chromatography technology	Huttlin EL (2017)	1
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
RASA1	3	DOK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dunant NM (2000), Yamanashi Y (1997), Nemorin JG (2000), Liu BA (2012), Di Cristofano A (1998), Bhat A (1998), Wick MJ (2001), Kashige N (2000), Kashige N (2000), Kepley CL (2004)	10
NCK1	0	ABL2	4	imaging technique	Chen TC (2014)	1
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
ITGB3	6	ITGB1	4	imaging technique	Moon HE (2015)	1
EGFR	5	HCK	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	RET	3	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Bhinge K (2017), Bhinge K (2017)	4
RASA1	3	SRC	2	affinity chromatography technology, enzymatic study	Brott BK (1991), Giglione C (2001)	2
INPP5D	2	BCR	3	affinity chromatography technology	Ruschmann J (2010)	1
DOK1	2	ITGB1	4	pull down	Anthis NJ (2009)	1
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
SRC	2	ITGB3	6	enzymatic study	Kirk RI (2000)	1
TEC	2	VAV1	2	affinity chromatography technology	Kline JB (2001)	1
BCR	3	HCK	5	affinity chromatography technology, affinity chromatography technology	Stanglmaier M (2003), Lionberger JM (2000)	2
GRB2	2	INPP5D	2	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavanaugh WM (1996), Kavanaugh WM (1996), de Castro RO (2012), Ho JM (2002)	4
DOK1	2	VAV1	2	unspecified method	Liu BA (2012)	1
GRB2	2	RET	3	pull down, pull down, affinity chromatography technology, pull down	Borrello MG (1994), Pandey A (1995), Scott RP (2005), Besset V (2000)	4
ABL1	9	ERBB2	6	unspecified method	Jones RB (2006)	1
BCR	3	KIT	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Hallek M (1996), Hallek M (1996), Chen TC (2014)	3
DOK1	2	PTK6	1	unspecified method	Liu BA (2012)	1
INPP5D	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), Wisniewski D (1999), Leitges M (2002), Damen JE (1996), Damen JE (1996), March ME (2000), Hunter MG (2004), Ho JM (2002)	9
ABL1	9	GRB2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994)	11
SH2D1A	0	EGFR	5	unspecified method	Jones RB (2006)	1
VAV1	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Bertagnolo V (1998), Bertagnolo V (1998), Bertagnolo V (1998), Shigematsu H (1997), Shigematsu H (1997), Shigematsu H (1997)	6
DOK1	2	PIK3R1	6	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
RET	3	DOK1	2	two hybrid, pull down, affinity chromatography technology	Murakami H (2002), Murakami H (2002), Murakami H (2002)	3
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
INSR	9	DOK1	2	enzymatic study	Wick MJ (2001)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
BCR	3	CRKL	1	affinity chromatography technology, two hybrid, two hybrid, far western blotting, affinity chromatography technology	Heaney C (1997), Heaney C (1997), Kolibaba KS (1999), Kolibaba KS (1999), Million RP (2004)	5
NCK1	0	ABL1	9	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Miyoshi-Akiyama T (2001), Ren R (1994), Ren R (1994), Wunderlich L (1999), Adler CE (2000)	5
DOK1	2	ABL1	9	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	van Dijk TB (2000), Yamanashi Y (1997), Yamanashi Y (1997), Johnson KJ (2009), Liu BA (2012), Bhat A (1998), Bhat A (1998), Bhat A (1998), Kashige N (2000)	9
ABL1	9	PIK3R1	6	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Kapeller R (1994), Ren SY (2005), Ren SY (2005), Ren SY (2005), Brehme M (2009)	5
CRKL	1	INPP5D	2	pull down, affinity chromatography technology	Arai A (2001), Arai A (2001)	2
NCK1	0	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	6
DOK1	2	DOK1	2	affinity chromatography technology	Liang X (2002)	1
SHC1	0	RET	3	affinity chromatography technology, pull down, affinity chromatography technology	Arighi E (1997), Arighi E (1997), Borrello MG (1994)	3
INSR	9	PLCG1	6	unspecified method	Liu BA (2012)	1
DOK1	2	CRK	0	unspecified method	Liu BA (2012)	1
PIK3R1	6	CD28	0	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pages F (1996), Pages F (1996), Alcazar I (2009), Fang D (2001)	4
GRB2	2	RASA1	3	affinity chromatography technology	Lamprecht R (2002)	1
ERBB2	6	RASA1	3	unspecified method	Jones RB (2006)	1
CD28	0	VAV1	2	affinity chromatography technology	Klasen S (1998)	1
EGFR	5	ITK	7	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
DOK1	2	DOK2	2	affinity chromatography technology	Dunant NM (2000)	1
CRKL	1	ABL1	9	affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heaney C (1997), Heaney C (1997), Heaney C (1997), Ren R (1994), Ren R (1994), Kyono WT (1998), Ren R (1994), Patel H (2006), Johnson KJ (2009), Ribon V (1996), Senechal K (1998), Nishihara T (2003), Peterson ME (2008)	13
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
ITGB3	6	SHC1	0	affinity chromatography technology, unspecified method	Lee DY (2010), Kirk RI (2000)	2
INSR	9	RASA1	3	affinity chromatography technology	Pronk GJ (1992)	1
TEC	2	DOK1	2	affinity chromatography technology, enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	4
SHC1	0	SRC	2	pull down	Schueller AC (2008)	1
ERBB2	6	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid	Schulze WX (2006), Wong L (1999), Olayioye MA (1998), Crovello CS (1998), Jones RB (2006), Yao Z (2017)	6
HCK	5	RASA1	3	affinity chromatography technology, pull down	Briggs SD (1995), Briggs SD (1995)	2
ITK	7	GRB2	2	pull down, pull down	Bunnell SC (2000), Andreotti AH (1997)	2
ERBB2	6	ABL2	4	unspecified method	Jones RB (2006)	1
ERBB2	6	CRKL	1	unspecified method	Jones RB (2006)	1
DOK1	2	HCK	5	pull down	van Dijk TB (2000)	1
INPP5D	2	DOK1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), van Dijk TB (2000), Kepley CL (2004)	4
BCR	3	PIK3R1	6	far western blotting	Weinger JG (2008)	1
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
KIT	4	PLCG1	6	pull down, pull down, imaging technique	van Dijk TB (2000), Jhun BH (1995), Chen TC (2014)	3
ERBB2	6	TLN1	5	unspecified method	Jones RB (2006)	1
CRK	0	DOK3	5	two hybrid	Grossmann A (2015)	1
ERBB2	6	PIK3R1	6	affinity chromatography technology, unspecified method	Crovello CS (1998), Jones RB (2006)	2
DOK2	2	NCK1	0	affinity chromatography technology	Master Z (2001)	1
RASA1	3	YES1	1	affinity chromatography technology	Cichowski K (1992)	1
CD28	0	DOK1	2	affinity chromatography technology	Klasen S (1998)	1
DOK1	2	KIT	4	affinity chromatography technology, pull down	Liang X (2002), Liang X (2002)	2
SRC	2	TLN1	5	affinity chromatography technology	Lee J (2013)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1
KIT	4	CRKL	1	pull down, affinity chromatography technology	van Dijk TB (2000), Sattler M (1997)	2