PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DKK1	1	DPP4	3	two hybrid	Wang J (2011)	1
DPP4	3	BCL10	0	affinity chromatography technology	Ohnuma K (2007)	1
DPP4	3	IKBKB	1	affinity chromatography technology	Ohnuma K (2007)	1
CARD11	4	DPP4	3	affinity chromatography technology, affinity chromatography technology	Ohnuma K (2007), Ohnuma K (2007)	2
FAP	1	DPP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Knopf JD (2015), Knopf JD (2015), Knopf JD (2015)	3
DPP4	3	ADA	0	affinity chromatography technology	Knopf JD (2015)	1
EGFR	5	DPP4	3	affinity chromatography technology	Yao Z (2017)	1
BCL10	0	IKBKB	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Lobry C (2007), Lobry C (2007), Poyet JL (2001), Zhou H (2004), Bidere N (2009)	5
DPP4	3	CCL22	1	enzymatic study	Proost P (1999)	1
FAP	1	ADA	0	affinity chromatography technology, affinity chromatography technology	Knopf JD (2015), Knopf JD (2015)	2
BCL10	0	CARD11	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Kojo S (2009), Welteke V (2009), Oruganti SR (2011), Langel FD (2008), McCully RR (2008), Sommer K (2005), Park Y (2013), Chen J (2015), Qiao Q (2013), Qiao Q (2013), Eitelhuber AC (2011), Yang YK (2016), Liu Y (2012), Bidere N (2009)	17