PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIAH1	2	GAPDH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee SY (2012), Lee SB (2012), Tristan CA (2015), Suarez S (2015)	4
RBFOX2	5	PRRC2A	10	affinity chromatography technology	Huttlin EL (2015)	1
BAG6	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
DVL2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Wei W (2012), Wei W (2012), Wei W (2012), Mund T (2015), Mund T (2015), Mund T (2015)	6
ATN1	2	NELL2	1	two hybrid	Lim J (2006)	1
ATN1	2	KAT6A	19	two hybrid	Lim J (2006)	1
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
ATN1	2	WWP2	7	two hybrid, pull down, two hybrid	Wood JD (1998), Wood JD (1998), Lim J (2006)	3
ATN1	2	PSME3	0	two hybrid	Lim J (2006)	1
ATN1	2	BAIAP2	6	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Okamura-Oho Y (1999), Okamura-Oho Y (1999), Okamura-Oho Y (1999), Okamura-Oho Y (1999), Lim J (2006)	5
PRRC2A	10	EWSR1	2	two hybrid	Wang J (2011)	1
RERE	9	EFEMP2	0	two hybrid	Lim J (2006)	1
NCK2	2	BAIAP2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATN1	2	NELL1	3	two hybrid	Lim J (2006)	1
ATN1	2	CACNB1	0	two hybrid	Lim J (2006)	1
TRIM25	5	EFEMP1	1	affinity chromatography technology	Choudhury NR (2017)	1
TERF2	2	PFKL	6	affinity chromatography technology	Giannone RJ (2010)	1
RERE	9	PRRC2B	9	two hybrid	Lim J (2006)	1
RERE	9	KRTAP4-12	2	two hybrid	Lim J (2006)	1
RBFOX1	1	ECM1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
ATN1	2	MAP7D1	2	two hybrid	Lim J (2006)	1
PLSCR1	0	EFEMP2	0	two hybrid	Rual JF (2005)	1
HINFP	0	ATN1	2	two hybrid	Miele A (2007)	1
RERE	9	KAT6A	19	two hybrid	Lim J (2006)	1
NELL1	3	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF115	1	ATN1	2	two hybrid	Bacopulos S (2012)	1
TERF2	2	WDR5	2	affinity chromatography technology	Giannone RJ (2010)	1
RERE	9	NR2E1	0	pull down	Wang L (2006)	1
EWSR1	2	BAG6	2	bioid	Elzi DJ (2014)	1
ATN1	2	RCHY1	0	two hybrid	Lim J (2006)	1
KAT6A	19	WDR5	2	affinity chromatography technology	Paggetti J (2010)	1
EWSR1	2	WWP2	7	two hybrid	Rual JF (2005)	1
AES	2	TLE1	6	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dastidar SG (2012)	2
RHOXF2	0	LENG8	2	two hybrid	Rual JF (2005)	1
ATN1	2	PRRC2A	10	two hybrid	Lim J (2006)	1
AES	2	RBM10	1	two hybrid	Rolland T (2014)	1
ATN1	2	EFEMP2	0	two hybrid	Lim J (2006)	1
ATN1	2	NOC2L	5	two hybrid	Lim J (2006)	1
WDR5	2	RERE	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
ATN1	2	AES	2	two hybrid	Lim J (2006)	1
DVL1	5	PSMA3	1	two hybrid	Wang J (2011)	1
RERE	9	PRRC2A	10	two hybrid	Lim J (2006)	1
ATN1	2	GRN	2	two hybrid	Lim J (2006)	1
EWSR1	2	GAPDH	0	affinity chromatography technology	Elzi DJ (2014)	1
ATN1	2	LENG8	2	two hybrid	Lim J (2006)	1
PSMA3	1	WDR5	2	affinity chromatography technology	Fedorova OA (2011)	1
SYVN1	2	BAG6	2	affinity chromatography technology	Zhang T (2015)	1
RERE	9	EFEMP1	1	two hybrid	Lim J (2006)	1
RBPMS	0	EFEMP2	0	two hybrid	Rolland T (2014)	1
ATN1	2	RAD54L2	5	two hybrid	Lim J (2006)	1
GIGYF2	7	MAGI1	3	affinity chromatography technology	Boldt K (2016)	1
WWOX	3	ATN1	2	affinity chromatography technology	Abu-Odeh M (2014)	1
ATN1	2	PFKL	6	two hybrid	Lim J (2006)	1
ATN1	2	GCC1	1	two hybrid	Lim J (2006)	1
ATN1	2	RNF31	3	two hybrid	Lim J (2006)	1
GIGYF1	15	GIGYF2	7	affinity chromatography technology	Boldt K (2016)	1
ATN1	2	EFEMP1	1	two hybrid	Lim J (2006)	1
AES	2	RBPMS	0	two hybrid	Rolland T (2014)	1
EWSR1	2	MEGF11	7	bioid	Elzi DJ (2014)	1
ATN1	2	ALG13	9	two hybrid	Lim J (2006)	1
GIGYF1	15	MAGI1	3	affinity chromatography technology	Boldt K (2016)	1
TRIM25	5	JAG2	6	affinity chromatography technology	Choudhury NR (2017)	1
AUTS2	10	ATN1	2	affinity chromatography technology	Gao Z (2014)	1
RBPMS	0	RBFOX2	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
ATN1	2	STXBP4	0	two hybrid	Lim J (2006)	1
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
WWOX	3	DVL2	5	affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Huttlin EL (2017)	2
PLSCR1	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ATN1	2	WWP1	3	two hybrid, two hybrid	Wood JD (1998), Lim J (2006)	2
ATN1	2	TLE1	6	two hybrid	Stelzl U (2005)	1
PSMA3	1	RBFOX2	5	two hybrid	Rolland T (2014)	1
ATN1	2	JAG2	6	two hybrid	Lim J (2006)	1
TRIM25	5	GAPDH	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
AES	2	RNF31	3	two hybrid	Rolland T (2014)	1
EWSR1	2	PLSCR1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM25	5	TLE1	6	affinity chromatography technology	Choudhury NR (2017)	1
DVL1	5	ITCH	1	affinity chromatography technology	Wei W (2012)	1
ATN1	2	MEGF8	9	two hybrid	Lim J (2006)	1
RERE	9	ATN1	2	pull down, pull down, two hybrid, two hybrid	Yanagisawa H (2000), Yanagisawa H (2000), Lim J (2006), Lim J (2006)	4
LYST	8	CENPJ	6	two hybrid	Tchernev VT (2002)	1
ATN1	2	ARF3	0	two hybrid	Lim J (2006)	1
AES	2	RHOXF2	0	two hybrid	Rolland T (2014)	1
ATN1	2	GIGYF1	15	two hybrid	Lim J (2006)	1
ATN1	2	NCK2	2	two hybrid	Lim J (2006)	1
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATN1	2	PCSK5	9	two hybrid	Lim J (2006)	1
ATN1	2	MEGF6	4	two hybrid	Lim J (2006)	1
ATN1	2	MBP	0	two hybrid	Lim J (2006)	1
ATN1	2	CRIP2	0	two hybrid	Lim J (2006)	1
ATN1	2	NR2E1	0	pull down	Wang L (2006)	1
ATN1	2	EWSR1	2	two hybrid, bioid	Lim J (2006), Elzi DJ (2014)	2
ATN1	2	CHRD	5	two hybrid	Lim J (2006)	1
TRIM25	5	PSMA3	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PSME3	0	affinity chromatography technology	Choudhury NR (2017)	1
ATN1	2	LTBP4	6	two hybrid	Lim J (2006)	1
WWOX	3	PRRC2A	10	affinity chromatography technology	Abu-Odeh M (2014)	1
AES	2	KRT31	0	two hybrid	Rolland T (2014)	1
DVL1	5	NCK2	2	two hybrid	Rolland T (2014)	1
DVL2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Mund T (2015), Mund T (2015), Mund T (2015)	3
TERF1	1	ATN1	2	affinity chromatography technology	Giannone RJ (2010)	1
BAG6	2	RNF115	1	biochemical	Rodrigo-Brenni MC (2014)	1
ATN1	2	RBPMS	0	two hybrid	Lim J (2006)	1
ATN1	2	SIAH2	0	two hybrid	Lim J (2006)	1
ATN1	2	TEP1	10	two hybrid	Lim J (2006)	1
ATN1	2	DVL2	5	two hybrid	Lim J (2006)	1
HSPG2	14	FBLN2	2	pull down, pull down	Hopf M (2001), Sasaki T (1995)	2
TRIM25	5	RBFOX2	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	NELL1	3	affinity chromatography technology	Choudhury NR (2017)	1
ATN1	2	BAG6	2	two hybrid	Lim J (2006)	1
PCSK5	9	KRTAP4-12	2	two hybrid	Rolland T (2014)	1
ATN1	2	ZSWIM8	8	two hybrid	Lim J (2006)	1
PSMA3	1	PSME3	0	biochemical	Wan C (2015)	1
ATN1	2	WDR5	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
WWP2	7	DVL1	5	affinity chromatography technology	Chaudhary N (2014)	1
RBFOX1	1	RBFOX2	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	DVL2	5	two hybrid	Lim J (2006)	1
TERF2	2	ATN1	2	affinity chromatography technology	Giannone RJ (2010)	1
FBLN1	1	LTBP4	6	two hybrid	Wang J (2011)	1
RBFOX1	1	RBPMS	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
RERE	9	ECM1	1	two hybrid	Lim J (2006)	1
LYST	8	ATN1	2	two hybrid	Tchernev VT (2002)	1
NELL2	1	LTBP4	6	affinity chromatography technology	Huttlin EL (2017)	1
EFEMP1	1	BAG6	2	two hybrid	Rolland T (2014)	1
TRIM25	5	RERE	9	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	FBLN1	1	affinity chromatography technology	Choudhury NR (2017)	1
ATN1	2	DMPK	3	two hybrid	Lim J (2006)	1
EWSR1	2	MDFI	1	two hybrid	Rual JF (2005)	1
TRIM25	5	HSPG2	14	affinity chromatography technology	Choudhury NR (2017)	1
TERF1	1	GAPDH	0	two hybrid	Lee OH (2011)	1
AUTS2	10	WDR5	2	affinity chromatography technology	Gao Z (2014)	1
RERE	9	ZMYND8	5	two hybrid	Lim J (2006)	1
ATN1	2	VIM	0	two hybrid	Stelzl U (2005)	1
ATN1	2	CTNND2	2	two hybrid	Okamura-Oho Y (1999)	1
ATN1	2	TRIP6	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
TRIM25	5	BAIAP2	6	affinity chromatography technology	Choudhury NR (2017)	1
ATN1	2	ZMYND8	5	two hybrid	Lim J (2006)	1
GIGYF2	7	ATN1	2	affinity chromatography technology	Ash MR (2010)	1
ATN1	2	DVL1	5	two hybrid	Okamura-Oho Y (1999)	1
ATN1	2	CENPJ	6	two hybrid	Lim J (2006)	1
PSMA3	1	GAPDH	0	affinity chromatography technology	Fedorova OA (2011)	1
ATN1	2	USP54	5	two hybrid	Lim J (2006)	1
RBFOX1	1	NOC2L	5	two hybrid	Lim J (2006)	1
AUTS2	10	RERE	9	affinity chromatography technology	Gao Z (2014)	1
DVL2	5	RBPMS	0	two hybrid	Rual JF (2005)	1
WWOX	3	BAIAP2	6	affinity chromatography technology	Abu-Odeh M (2014)	1
RBFOX1	1	RHOXF2	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Corominas R (2014)	3
ATN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
BAG6	2	WWP2	7	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
DVL2	5	WWP2	7	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Mund T (2015), Mund T (2015), Mund T (2015), Mund T (2015), Chaudhary N (2014)	5
ATN1	2	RBM10	1	two hybrid	Lim J (2006)	1
EFEMP1	1	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
RERE	9	CBFA2T2	3	two hybrid	Lim J (2006)	1
RERE	9	RBFOX2	5	two hybrid	Lim J (2006)	1
PRRC2A	10	PSMA3	1	two hybrid	Lehner B (2004)	1
TERF2	2	SIAH1	2	pull down, enzymatic study	Fujita K (2010), Fujita K (2010)	2
TRIM25	5	GIGYF2	7	affinity chromatography technology	Choudhury NR (2017)	1
NCK2	2	PRRC2A	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	ATN1	2	affinity chromatography technology	Choudhury NR (2017)	1
AES	2	CRACR2A	0	two hybrid	Rolland T (2014)	1
ATN1	2	KRT31	0	two hybrid	Lim J (2006)	1
EFEMP1	1	LTBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
ATN1	2	RUNX1T1	1	two hybrid, affinity chromatography technology, two hybrid	Wood JD (2000), Wood JD (2000), Lim J (2006)	3
RUNX1T1	1	CBFA2T2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Lindberg SR (2003), Hoogeveen AT (2002), Zhang J (2004)	4
ATN1	2	LRP2	13	two hybrid	Lim J (2006)	1
FBLN1	1	PLSCR1	0	two hybrid	Wang J (2011)	1
ATN1	2	PSMA3	1	two hybrid	Lim J (2006)	1
TERF2	2	TEP1	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bhattacharyya S (2009), Bhattacharyya S (2009), Bhattacharyya S (2009)	3
PFKL	6	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ATN1	2	MEGF11	7	two hybrid	Lim J (2006)	1
ATN1	2	GAPDH	0	two hybrid	Lim J (2006)	1
RERE	9	PLSCR1	0	two hybrid	Lim J (2006)	1
ATN1	2	KAT6B	27	two hybrid	Lim J (2006)	1
WWOX	3	DVL1	5	affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014)	2
RBFOX1	1	ATN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATN1	2	AGRN	11	two hybrid	Lim J (2006)	1
ATN1	2	RBFOX2	5	two hybrid	Lim J (2006)	1
ATN1	2	HSPG2	14	two hybrid	Lim J (2006)	1
RERE	9	ALG13	9	two hybrid	Lim J (2006)	1
ATN1	2	SIAH1	2	two hybrid, two hybrid	Lim J (2006), Wang J (2011)	2
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
ITCH	1	EWSR1	2	pull down	Ingham RJ (2005)	1
SYVN1	2	PSMA3	1	affinity chromatography technology	Christianson JC (2012)	1
ATN1	2	PLSCR1	0	two hybrid	Lim J (2006)	1
TRIM25	5	ARF3	0	affinity chromatography technology	Choudhury NR (2017)	1
PLSCR1	0	CHRD	5	two hybrid	Rolland T (2014)	1
EFEMP2	0	RHOXF2	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ATN1	2	ATN1	2	two hybrid	Lim J (2006)	1
RBFOX2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
ATN1	2	MDFI	1	two hybrid	Lim J (2006)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
ATN1	2	MAGI1	3	two hybrid, pull down	Wood JD (1998), Wood JD (1998)	2
WWP2	7	PRRC2A	10	affinity chromatography technology	Chaudhary N (2014)	1
ATN1	2	LTBP1	4	two hybrid	Lim J (2006)	1
ATN1	2	SYVN1	2	two hybrid	Lim J (2006)	1
WWP2	7	WDR5	2	affinity chromatography technology	Chaudhary N (2014)	1
RBFOX1	1	ALG13	9	two hybrid	Corominas R (2014)	1
EWSR1	2	WWP1	3	two hybrid	Rual JF (2005)	1
ATN1	2	ECM1	1	two hybrid	Lim J (2006)	1
ATN1	2	SLIT1	6	two hybrid	Lim J (2006)	1
EWSR1	2	RBPMS	0	two hybrid	Rual JF (2005)	1
ATN1	2	FBLN1	1	two hybrid	Lim J (2006)	1
DVL1	5	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2015), Huttlin EL (2017)	3
VIM	0	KAT7	3	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Goehler H (2004)	4
DVL2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
ATN1	2	KAT7	3	two hybrid	Stelzl U (2005)	1
ATN1	2	SPAG5	1	two hybrid	Lim J (2006)	1
ATN1	2	PRRC2B	9	two hybrid	Lim J (2006)	1
MDFI	1	CBFA2T2	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Yu H (2011)	3
TRIM25	5	BAG6	2	affinity chromatography technology	Choudhury NR (2017)	1
RBFOX1	1	PRRC2A	10	two hybrid	Lim J (2006)	1
ATN1	2	FBLN5	1	two hybrid	Lim J (2006)	1
ATN1	2	MAGI2	3	two hybrid, pull down	Wood JD (1998), Wood JD (1998)	2
TRIP6	2	NCK2	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PSMA3	1	RAD54L2	5	two hybrid	Rolland T (2014)	1
ATN1	2	FBLN2	2	two hybrid	Lim J (2006)	1
ATN1	2	KRTAP4-12	2	two hybrid	Lim J (2006)	1
TRIM25	5	USP54	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	WWOX	3	affinity chromatography technology	Choudhury NR (2017)	1
ATN1	2	ITCH	1	two hybrid, pull down	Wood JD (1998), Wood JD (1998)	2
WWOX	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014)	3
ATN1	2	CBFA2T2	3	two hybrid	Lim J (2006)	1
RBPMS	0	RAD54L2	5	two hybrid	Yu H (2011)	1
NELL1	3	LTBP4	6	affinity chromatography technology	Huttlin EL (2017)	1
ATN1	2	CRACR2A	0	two hybrid	Lim J (2006)	1
EWSR1	2	RHOXF2	0	two hybrid	Rual JF (2005)	1
RERE	9	PSMA3	1	two hybrid	Lim J (2006)	1
SIAH1	2	RAD54L2	5	two hybrid	Rolland T (2014)	1
LRP2	13	MAGI1	3	two hybrid, pull down	Patrie KM (2001), Patrie KM (2001)	2
ATN1	2	SSPO	11	two hybrid	Lim J (2006)	1