PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HDAC1	4	TFDP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
TFDP3	0	E2F3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
23429	0	TFDP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
TFDP1	3	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
TRIM25	5	MSH2	4	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	MCM4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
E2F3	0	MGA	9	two hybrid	Giangrande PH (2003)	1
CREBBP	29	BCL6	6	enzymatic study	Pasqualucci L (2011)	1
FZR1	1	E2F3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ping Z (2012), Ping Z (2012), Ping Z (2012)	3
DNMT3L	2	E2F3	0	pull down	Pacaud R (2014)	1
ELAVL1	0	USF1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BCL6	6	E2F3	0	affinity chromatography technology	Miles RR (2005)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CCNB1	3	PCNA	0	affinity chromatography technology, affinity chromatography technology	Zhang H (1993), Huttlin EL (2017)	2
E2F3	0	ATAD2	6	affinity chromatography technology, pull down	Revenko AS (2010), Revenko AS (2010)	2
HDAC1	4	TRIM28	1	affinity chromatography technology, affinity chromatography technology, biochemical	Allouch A (2011), Chen L (2012), Kristensen AR (2012)	3
E2F3	0	TEAD3	0	two hybrid	Giangrande PH (2003)	1
E2F3	0	CREBBP	29	two hybrid	Giangrande PH (2003)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM28	1	CREBBP	29	affinity chromatography technology	Seki Y (2010)	1
ELAVL1	0	23429	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MYBL2	2	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology	Bessa M (2001), Bessa M (2001), Kurahashi T (2005)	3
TRIM25	5	E2F3	0	affinity chromatography technology	Choudhury NR (2017)	1
USF1	0	FHL2	0	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	TFDP1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
USF1	0	E2F3	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Giangrande PH (2004), Giangrande PH (2004), Giangrande PH (2004)	3
RBL1	1	MYBL2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Joaquin M (2003), Joaquin M (2002), Joaquin M (2002), Schmit F (2007)	4
PCNA	0	MCM4	3	affinity chromatography technology	Han J (2014)	1
TRIM25	5	23429	0	affinity chromatography technology	Choudhury NR (2017)	1
E2F3	0	SPIB	3	two hybrid	Giangrande PH (2003)	1
TRIM25	5	ATAD2	6	affinity chromatography technology	Choudhury NR (2017)	1
RB1	2	FZR1	1	affinity chromatography technology, biochemical	Binne UK (2007), Binne UK (2007)	2
TRIM28	1	HCFC1	4	biochemical	Wan C (2015)	1
CCNB1	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Lin Z (2015), Lin Z (2015)	2
MSH2	4	E2F3	0	imaging technique	Chen TC (2014)	1
HDAC1	4	E2F3	0	affinity chromatography technology	Chen L (2012)	1
E2F3	0	PKIB	0	two hybrid	Giangrande PH (2003)	1
23429	0	MGA	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
RB1	2	TFDP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu CL (1995), Binne UK (2007), Hauri S (2016)	3
RB1	2	HDAC1	4	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fuks F (2000), Puri PL (2001), Puri PL (2001), Wang S (2002), Luo RX (1998), Luo RX (1998), Lai A (1999), Lai A (1999), Ferreira R (1998), Kimura H (2003), Qiu Z (2008), Fedele M (2006), Brown VD (2002), Khan MM (2001), Dasgupta P (2004), Chang YC (2001), Dahiya A (2000), Zhang HS (2000), Tokitou F (1999), Nguyen DX (2004), Takaki T (2004), Magnaghi-Jaulin L (1998), Magnaghi-Jaulin L (1998), Brehm A (1998), Brehm A (1998), Brehm A (1998), Sun JM (2007), Fan LX (2012), Harbour JW (1999), Brehm A (1999), Joshi P (2013), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	36
TFDP1	3	E2F3	0	imaging technique, affinity chromatography technology	Magae J (1996), Hauri S (2016)	2
TRIM25	5	PCNA	0	affinity chromatography technology, affinity chromatography technology	Park JM (2014), Park JM (2014)	2
HCFC1	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003)	2
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
TFDP3	0	RB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
23429	0	TFDP2	1	affinity chromatography technology	Huttlin EL (2017)	1
RBL1	1	TFDP1	3	affinity chromatography technology	Wu CL (1995)	1
E2F3	0	TFE3	4	two hybrid, pull down, affinity chromatography technology	Giangrande PH (2003), Giangrande PH (2003), Giangrande PH (2003)	3
TRIM25	5	FZR1	1	affinity chromatography technology	Choudhury NR (2017)	1
CREBBP	29	PCNA	0	affinity chromatography technology, pull down, enzymatic study	Cazzalini O (2014), Cazzalini O (2014), Cazzalini O (2014)	3
E2F3	0	RNF144A	1	two hybrid	Schlisio S (2002)	1
RBL1	1	TFDP2	1	affinity chromatography technology	Wu CL (1995)	1
E2F3	0	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inoue Y (2007), Moberg K (1996), Ianari A (2009), Lees JA (1993)	4
E2F3	0	RBL1	1	affinity chromatography technology, affinity chromatography technology	von Eyss B (2011), Moberg K (1996)	2
TFDP1	3	MGA	9	affinity chromatography technology	Hauri S (2016)	1
TRIM25	5	WNK1	7	affinity chromatography technology	Choudhury NR (2017)	1
HDAC1	4	BCL6	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	David G (1998), Deltour S (1999), Fujita N (2004), Fujita N (2004), Dhordain P (1998), Miles RR (2005)	6
HDAC1	4	HELLS	1	imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Zhou R (2009), Zhou R (2009), Zhou R (2009), Zhou R (2009), Myant K (2008)	5
E2F3	0	MCM4	3	affinity chromatography technology	von Eyss B (2011)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
USF1	0	HCFC1	4	affinity chromatography technology, affinity chromatography technology	Huang S (2007), Li X (2011)	2
HCFC1	4	E2F3	0	affinity chromatography technology, two hybrid	Tyagi S (2007), Tyagi S (2007)	2
TRIM28	1	E2F3	0	affinity chromatography technology, affinity chromatography technology	Chen L (2012), Chen L (2012)	2
E2F3	0	WNK1	7	two hybrid	Giangrande PH (2003)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
E2F3	0	HELLS	1	affinity chromatography technology, pull down, affinity chromatography technology	von Eyss B (2011), von Eyss B (2011), von Eyss B (2011)	3
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
ELAVL1	0	HCFC1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	E2F3	0	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	TEAD3	0	affinity chromatography technology	Choudhury NR (2017)	1
CREBBP	29	FHL2	0	affinity chromatography technology	Labalette C (2004)	1
RB1	2	TFDP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu CL (1995), Huttlin EL (2015), Huttlin EL (2017)	3
E2F3	0	MYBL2	2	two hybrid	Giangrande PH (2003)	1
CCNB1	3	RB1	2	enzymatic study, enzymatic study	Jiang W (1998), Knudsen ES (1997)	2
23429	0	HDAC1	4	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	MSH2	4	affinity chromatography technology, far western blotting	Ohta S (2002), Dzantiev L (2004)	2
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
TRIM25	5	HELLS	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MCM4	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	TRIM28	1	affinity chromatography technology	Choudhury NR (2017)	1
PCNA	0	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Milutinovic S (2002), Milutinovic S (2002), Naryzhny SN (2004)	3
E2F3	0	PCNA	0	affinity chromatography technology	von Eyss B (2011)	1
ELAVL1	0	E2F3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CREBBP	29	MSH2	4	affinity chromatography technology	Jung SY (2005)	1
E2F3	0	KMT2D	30	affinity chromatography technology	Takeda S (2006)	1
E2F3	0	CCNB1	3	affinity chromatography technology	von Eyss B (2011)	1
TFDP1	3	CREBBP	29	pull down, affinity chromatography technology	Trouche D (1996), Nath S (2014)	2
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
E2F3	0	23429	0	two hybrid, affinity chromatography technology	Schlisio S (2002), Schlisio S (2002)	2
HDAC1	4	MGA	9	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
E2F3	0	UCHL5	1	pull down	Mahanic CS (2015)	1
HNRNPL	3	RNF144A	1	affinity chromatography technology	Fei T (2017)	1
HDAC1	4	RBL1	1	affinity chromatography technology, affinity chromatography technology, pull down	Lai A (1999), Ferreira R (1998), Ferreira R (1998)	3
HNRNPL	3	CREBBP	29	affinity chromatography technology	Fei T (2017)	1
E2F3	0	FHL2	0	two hybrid	Schlisio S (2002)	1
TFE3	4	TRIM28	1	affinity chromatography technology	Ewing RM (2007)	1
E2F3	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
CCNB1	3	TRIM28	1	affinity chromatography technology, affinity chromatography technology	Lin Z (2015), Lin Z (2015)	2
TFDP2	1	E2F3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2