PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2K	0	ITSN1	5	two hybrid	Vinayagam A (2011)	1
UBE2D1	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kim JM (2010), Kang D (2002), Jung I (2012)	4
USP2	0	DTX3	4	two hybrid	Hayes SD (2012)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
UBE2L6	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2L3	1	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D3	1	CHFR	5	two hybrid, pull down, pull down	Markson G (2009), Chaturvedi P (2002), Liu C (2013)	3
RNF38	4	DTX3	4	two hybrid	Woodsmith J (2012)	1
USP21	2	DTX3	4	two hybrid	Hayes SD (2012)	1
UBE2E3	0	RNF114	0	two hybrid	Markson G (2009)	1
UBE2W	0	DTX3	4	two hybrid	Markson G (2009)	1
100131816	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
UBE2E2	1	CHFR	5	two hybrid	Markson G (2009)	1
DTX3	4	CHFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D4	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2H	3	RNF114	0	two hybrid	Markson G (2009)	1
UBE2D4	0	XIAP	0	two hybrid	Markson G (2009)	1
ZDHHC17	1	UBE2K	0	two hybrid	Butland SL (2014)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E3	0	DTX3	4	two hybrid	Markson G (2009)	1
USP1	4	DTX3	4	two hybrid	Hayes SD (2012)	1
DTX3	4	GDA	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E3	0	CHFR	5	two hybrid	Markson G (2009)	1
XIAP	0	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
XIAP	0	UBE2E1	1	two hybrid, pull down	Dynek JN (2010), Markson G (2009)	2
UBE2W	0	CHFR	5	two hybrid	Markson G (2009)	1
UBE2E1	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
UBE2D1	0	DTX3	4	two hybrid	Markson G (2009)	1
DTX3	4	FARSB	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Morizane Y (2005), Janzer A (2012), Liu WH (2007), Takeda AN (2014), Markson G (2009), Hao Y (2004), Hanson AJ (2012)	10
UBE2D3	1	DTX3	4	two hybrid	Markson G (2009)	1
DTX3	4	NMD3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E2	1	RNF114	0	two hybrid	Markson G (2009)	1
TRAF4	1	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
UEVLD	3	RNF114	0	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF38	4	two hybrid	Markson G (2009)	1
ZDHHC17	1	RNF38	4	two hybrid	Butland SL (2014)	1
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
UBE2D2	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kang D (2002), Oh YM (2009), Chaturvedi P (2002)	4
DTX3	4	ITSN1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF141	2	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2K	0	DTX3	4	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2D2	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2W	0	RNF114	0	two hybrid	Markson G (2009)	1
RNF114	0	RNF38	4	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF114	0	two hybrid	Markson G (2009)	1
DTX3	4	NDUFAF5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E1	1	DTX3	4	two hybrid	Markson G (2009)	1
DTX3	4	NARFL	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
UBE2D2	0	RNF38	4	two hybrid, pull down, pull down	Markson G (2009), Sheren JE (2013), Buetow L (2015)	3
TRAF4	1	RNF114	0	two hybrid	Woodsmith J (2012)	1
UBE2V1	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2E1	1	CHFR	5	two hybrid	Markson G (2009)	1
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
100131816	0	RNF114	0	two hybrid	Markson G (2009)	1
UBE2W	0	XIAP	0	two hybrid, two hybrid	Markson G (2009), Dynek JN (2010)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
XIAP	0	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
UBE2D1	0	RNF38	4	two hybrid	Markson G (2009)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
USP1	4	UBE2K	0	enzymatic study	Das DS (2017)	1
UEVLD	3	DTX3	4	two hybrid	Markson G (2009)	1
UBE2H	3	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D4	0	CHFR	5	two hybrid	Markson G (2009)	1
ZDHHC17	1	DTX3	4	two hybrid	Butland SL (2014)	1
UBE2V1	0	XIAP	0	two hybrid	Markson G (2009)	1
UBE2E2	1	DTX3	4	two hybrid	Markson G (2009)	1
LYN	2	DTX3	4	affinity chromatography technology	Zhu J (2013)	1
UBE2E2	1	XIAP	0	two hybrid	Markson G (2009)	1
UBE2D3	1	RNF38	4	two hybrid	Markson G (2009)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
DTX3	4	MAPK9	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DTX3	4	NDUFS6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Bartke T (2004), Bornstein B (2011), Damgaard RB (2013), Markson G (2009)	7
UBE2H	3	RNF38	4	two hybrid	Markson G (2009)	1
UBE2K	0	RNF114	0	two hybrid	Markson G (2009)	1