PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELANE	0	SERPINB1	0	enzymatic study	Perani P (2000)	1
ELANE	0	SERPING1	2	enzymatic study	Brower MS (1982)	1
ELANE	0	KNG1	1	enzymatic study	Dulinski R (2003)	1
ELANE	0	NOTCH2NL	1	two hybrid, affinity chromatography technology, pull down	Duan Z (2004), Duan Z (2004), Duan Z (2004)	3
ELANE	0	SERPINA1	1	pull down	Taggart C (2000)	1
THBS1	6	ELANE	0	pull down	Hogg PJ (1993)	1
ELANE	0	SERPINF2	0	enzymatic study, enzymatic study	Brower MS (1982), Shieh BH (1987)	2
ELANE	0	SERPINA3	2	enzymatic study	Stavridi ES (1996)	1