PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IGF2BP1	2	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Cassar PA (2015), Cassar PA (2015)	2
406891	0	PTBP1	2	affinity chromatography technology	Treiber T (2017)	1
ELAVL1	0	BMI1	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
MAEL	0	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Yuan L (2014), Yuan L (2014)	2
VHL	0	PRKCD	2	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Iturrioz X (2006), Iturrioz X (2006), Yong HJ (2017), Yong HJ (2017)	4
BMI1	0	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
BMI1	0	AGO2	10	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	ANP32B	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Gallouzi IE (2001)	2
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
MIRLET7B	0	RBFOX2	5	affinity chromatography technology	Treiber T (2017)	1
VHL	0	CHEK2	2	affinity chromatography technology, enzymatic study	Roe JS (2011), Roe JS (2011)	2
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
406891	0	HNRNPK	4	affinity chromatography technology	Treiber T (2017)	1
PLAUR	0	PLAU	1	pull down, pull down, affinity chromatography technology	Liang OD (2001), Crusius K (2006), Yin LL (2009)	3
TRIM25	5	FAF2	4	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	CELF2	5	pull down, two hybrid, two hybrid	Sureban SM (2007), Sureban SM (2007), Sureban SM (2007)	3
MIRLET7B	0	PTBP1	2	affinity chromatography technology	Treiber T (2017)	1
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
ERG	1	HNRNPA1	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
IGF2BP1	2	MKRN1	1	affinity chromatography technology, affinity chromatography technology	Cassar PA (2015), Cassar PA (2015)	2
HIF1A	1	VEGFA	3	imaging technique	Pawlus MR (2013)	1
VEGFA	3	VHL	0	genetic interference	Shen JP (2017)	1
TRIM25	5	AGO2	10	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	VEGFA	3	unspecified method, affinity chromatography technology	Datta K (2005), Xin H (2011)	2
HNRNPA1	1	PTBP1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Close P (2012), Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Wan C (2015)	5
406891	0	HNRNPA1	1	affinity chromatography technology	Treiber T (2017)	1
SREK1	3	HNRNPK	4	affinity chromatography technology	Li J (2003)	1
XIAP	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Lewis SM (2007), Lewis SM (2007), Roy R (2014)	3
ELAVL1	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Close P (2012), Roy R (2014), Hein MY (2015)	4
HNRNPA1	1	PCBP2	3	affinity chromatography technology	Roy R (2014)	1
PTBP1	2	RBFOX2	5	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
ELAVL1	0	406891	0	unspecified method, affinity chromatography technology	Yoon JH (2013), Yoon JH (2013)	2
ELAVL1	0	AGO2	10	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Balkhi MY (2013)	2
ELAVL1	0	PLAU	1	unspecified method, unspecified method	Tran H (2003), Tran H (2003)	2
AGO2	10	406891	0	unspecified method	Yoon JH (2013)	1
ELAVL1	0	PTBP2	1	affinity chromatography technology, two hybrid, two hybrid	Abdelmohsen K (2009), Hegele A (2012), Hegele A (2012)	3
TRIM25	5	PTBP1	2	affinity chromatography technology	Choudhury NR (2017)	1
SUZ12	0	VCP	6	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
PCBP2	3	PTBP1	2	two hybrid, two hybrid, pull down, pull down	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000)	4
BMI1	0	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
MIRLET7B	0	CELF1	0	affinity chromatography technology	Treiber T (2017)	1
BMI1	0	STAU1	1	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
HNRNPK	4	RBFOX2	5	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
G3BP1	4	STAU1	1	affinity chromatography technology	Jain S (2016)	1
ELAVL1	0	TCF3	7	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Teachenor R (2012)	2
HNRNPA1	1	IGF2BP1	2	affinity chromatography technology	Jeronimo C (2007)	1
BMI1	0	PTBP1	2	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	PTGS2	0	unspecified method, affinity chromatography technology, unspecified method	Kim I (2012), Kim I (2012), Sureban SM (2007)	3
ELAVL1	0	ELAVL1	0	two hybrid, pull down	Hegele A (2012), Sureban SM (2007)	2
CELF2	5	PTGS2	0	unspecified method	Sureban SM (2007)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
PTBP1	2	HIF1A	1	affinity chromatography technology, unspecified method	Galban S (2008), Galban S (2008)	2
MIRLET7B	0	HNRNPA1	1	affinity chromatography technology	Treiber T (2017)	1
TRIM25	5	RBFOX2	5	affinity chromatography technology	Choudhury NR (2017)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
ELAVL1	0	SET	8	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Gallouzi IE (2001)	2
ERG	1	ELAVL1	0	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
HDAC6	0	HIF1A	1	affinity chromatography technology	Qian DZ (2006)	1
HNRNPK	4	RBM3	1	two hybrid	Rolland T (2014)	1
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
ELAVL1	0	MIRLET7B	0	unspecified method, affinity chromatography technology	Yoon JH (2013), Yoon JH (2013)	2
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
ELAVL1	0	MKRN1	1	affinity chromatography technology, affinity chromatography technology	Cassar PA (2015), Cassar PA (2015)	2
SUZ12	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Choudhury NR (2017)	2
HNRNPA1	1	HNRNPK	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
ELAVL1	0	CELF1	0	affinity chromatography technology, biochemical	Abdelmohsen K (2009), Wan C (2015)	2
ELAVL1	0	PCBP2	3	affinity chromatography technology, biochemical	Abdelmohsen K (2009), Wan C (2015)	2
406891	0	RBFOX2	5	affinity chromatography technology	Treiber T (2017)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
PTBP1	2	HNRNPK	4	two hybrid, two hybrid, pull down, pull down, biochemical, biochemical	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000), Havugimana PC (2012), Wan C (2015)	6
PRKCA	7	HDAC6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Zhu J (2011), Zhu J (2011), Mertz JA (2011), Mertz JA (2011), Mertz JA (2011)	5
AGO2	10	BTRC	1	unspecified method	Elcheva I (2009)	1
SUZ12	0	PTBP1	2	affinity chromatography technology	Cao Q (2014)	1
HNRNPA1	1	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
PRKCD	2	VCP	6	pull down	Rex EB (2010)	1
SREK1	3	HNRNPA1	1	affinity chromatography technology	Li J (2003)	1
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
STAU1	1	IGF2BP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Milev MP (2012), Milev MP (2012), Milev MP (2012)	3
ELAVL1	0	HNRNPK	4	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
VCP	6	RBFOX2	5	affinity chromatography technology	Yu CC (2013)	1
ELAVL1	0	HIF1A	1	affinity chromatography technology, unspecified method	Galban S (2008), Galban S (2008)	2
IGF2BP1	2	BTRC	1	affinity chromatography technology	Noubissi FK (2006)	1
ELAVL1	0	RBM3	1	two hybrid, pull down, affinity chromatography technology	Sureban SM (2008), Sureban SM (2008), Zhu X (2016)	3
BTRC	1	HNRNPK	4	two hybrid	Wang J (2011)	1
PTGS2	0	VCP	6	affinity chromatography technology	Chen SF (2013)	1
BTRC	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2014), Huttlin EL (2017)	2
BTRC	1	BMI1	0	affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2011), Sahasrabuddhe AA (2011)	2
406891	0	IGF2BP1	2	affinity chromatography technology	Treiber T (2017)	1
G3BP1	4	CELF1	0	affinity chromatography technology	Jain S (2016)	1
406891	0	CELF2	5	affinity chromatography technology	Treiber T (2017)	1
VHL	0	HNRNPA1	1	affinity chromatography technology	Lai Y (2011)	1
VCP	6	CHEK2	2	affinity chromatography technology	Matsuoka S (2007)	1
STAU1	1	HNRNPA1	1	affinity chromatography technology	Milev MP (2012)	1
ELAVL1	0	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Jain S (2016)	2
ELAVL1	0	STAU1	1	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Milev MP (2012)	2
TRIM25	5	HNRNPA1	1	affinity chromatography technology	Choudhury NR (2017)	1
SREK1	3	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Li J (2003), Abdelmohsen K (2009)	2
BMI1	0	CELF1	0	affinity chromatography technology	Cao Q (2014)	1
HNRNPK	4	VCP	6	biochemical	Wan C (2015)	1
ELAVL1	0	PLAUR	0	unspecified method, unspecified method	Tran H (2003), Tran H (2003)	2
VHL	0	HNRNPK	4	affinity chromatography technology	Lai Y (2011)	1
ELAVL1	0	PTBP1	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Galban S (2008), Galban S (2008)	4
PRKCD	2	ELAVL1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Doller A (2007), Doller A (2008), Doller A (2008), Doller A (2011), Doller A (2011), Doller A (2010)	6
ERG	1	TRIM25	5	pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang S (2016), Wang S (2016), Wang S (2016), Wang S (2016), Wang S (2016)	5
TRIM25	5	BTRC	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	IGF2BP1	2	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	G3BP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Jain S (2016)	3
ELAVL1	0	RBFOX2	5	affinity chromatography technology, two hybrid, two hybrid	Abdelmohsen K (2009), Hegele A (2012), Hegele A (2012)	3
MIRLET7B	0	HNRNPK	4	affinity chromatography technology	Treiber T (2017)	1
G3BP1	4	AGO2	10	affinity chromatography technology	Jain S (2016)	1
PCBP2	3	HNRNPK	4	two hybrid, two hybrid, pull down, pull down	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000)	4
HDAC6	0	HNRNPK	4	affinity chromatography technology	Watson GW (2016)	1
FAF2	4	PTGS2	0	affinity chromatography technology	Raman M (2015)	1
TRAF3IP2	0	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Herjan T (2013), Herjan T (2013)	2
ELAVL1	0	PRKCA	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Abdelmohsen K (2009), Chu PC (2012), Doller A (2007), Doller A (2007)	4
VCP	6	HNRNPA1	1	affinity chromatography technology	Yu CC (2013)	1
MIRLET7B	0	IGF2BP1	2	affinity chromatography technology	Treiber T (2017)	1
TRIM25	5	CELF1	0	affinity chromatography technology	Choudhury NR (2017)	1
RBM3	1	HNRNPA1	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
MAEL	0	HNRNPA1	1	affinity chromatography technology	Yuan L (2014)	1
G3BP1	4	IGF2BP1	2	affinity chromatography technology	Jain S (2016)	1
G3BP1	4	VCP	6	affinity chromatography technology	Jain S (2016)	1
ELAVL1	0	CHEK2	2	affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Abdelmohsen K (2009), Abdelmohsen K (2007), Abdelmohsen K (2007), Abdelmohsen K (2007)	4
406891	0	CELF1	0	affinity chromatography technology	Treiber T (2017)	1
STAU1	1	HNRNPK	4	affinity chromatography technology	Milev MP (2012)	1
BMI1	0	RBFOX2	5	affinity chromatography technology	Cao Q (2014)	1
G3BP1	4	PTBP1	2	biochemical	Kristensen AR (2012)	1
AGO2	10	MIRLET7B	0	unspecified method	Yoon JH (2013)	1
FAF2	4	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
HDAC6	0	G3BP1	4	affinity chromatography technology, pull down	Kwon S (2007), Kwon S (2007)	2