PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RUNX1	0	ELF1	2	pull down	Mao S (1999)	1
NFKB1	2	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
ELF1	2	HSPBP1	0	affinity chromatography technology	Huttlin EL (2017)	1
SP1	0	REL	5	pull down	Sif S (1994)	1
HMGA1	0	ELF1	2	pull down	John S (1995)	1
SP1	0	NFYA	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Roder K (1999), Roder K (1999), Roder K (1999), Roder K (1999), Wang W (1999)	5
HMGA1	0	NFKB1	2	pull down	Munshi N (1998)	1
NFYA	2	HMGA1	0	far western blotting	Currie RA (1997)	1
SP1	0	ELF1	2	pull down	Gunther M (2000)	1
ELF1	2	REL	5	pull down	John S (1995)	1
NFYA	2	ELF1	2	pull down	Bemark M (1998)	1
ELF1	2	NFKB1	2	pull down, pull down	John S (1995), Bassuk AG (1997)	2
SP1	0	NFKB1	2	pull down, affinity chromatography technology, affinity chromatography technology	Sif S (1994), Dhar SK (2006), Liu S (2008)	3
HMGA1	0	SP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foti D (2003), Foti D (2003), Aiello A (2010), Aiello A (2010)	4
ELF1	2	HOXC13	0	affinity chromatography technology, affinity chromatography technology	Yamada T (2009), Yamada T (2009)	2