PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELF3	0	XRCC6	3	affinity chromatography technology, pull down	Wang H (2004), Wang H (2004)	2
ELF3	0	XRCC5	5	affinity chromatography technology, pull down	Wang H (2004), Wang H (2004)	2
ELF3	0	NFKB1	2	pull down, affinity chromatography technology, affinity chromatography technology	Rudders S (2001), Longoni N (2013), Longoni N (2013)	3
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
EP300	36	SOX9	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furumatsu T (2010), Furumatsu T (2010), Tsuda M (2003), Furumatsu T (2005)	4
AR	3	ELF3	0	affinity chromatography technology, pull down	Shatnawi A (2014), Shatnawi A (2014)	2
ELF3	0	DDX3X	52	affinity chromatography technology	Ewing RM (2007)	1
ELF3	0	ELF3	0	affinity chromatography technology	Kopp JL (2007)	1
MYC	2	TBP	0	pull down	McEwan IJ (1996)	1
PAK1	2	ERBB2	6	affinity chromatography technology	Adam L (1998)	1
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
NFKB1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Heissmeyer V (2001), Lang V (2003), Lang V (2003), Winston JT (1999), Winston JT (1999), Busino L (2012), Amir RE (2002), Coyaud E (2015), Coyaud E (2015), Zhang Z (2015), Huttlin EL (2017)	11
AR	3	CALR	1	pull down	Dedhar S (1994)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
ELF3	0	CALR	1	affinity chromatography technology	Ewing RM (2007)	1
ELF3	0	KRT82	7	affinity chromatography technology	Ewing RM (2007)	1
EHF	0	XRCC6	3	pull down, affinity chromatography technology	Wang H (2004), Wang H (2004)	2
ELF3	0	BTRC	1	affinity chromatography technology	Manavathi B (2007)	1
ISG15	0	TARS	2	affinity chromatography technology	Zhao C (2005)	1
TBP	0	EP300	36	affinity chromatography technology	Dallas PB (1997)	1
AR	3	XRCC6	3	affinity chromatography technology	Mayeur GL (2005)	1
TBP	0	TAF9	2	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Bellorini M (1997), Martinez E (2001), Knuesel MT (2009), Liu X (2008), Havugimana PC (2012)	5
MYC	2	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PAK1	2	RELA	1	affinity chromatography technology	Dammann K (2015)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
EP300	36	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kimbrel EA (2009), Kimbrel EA (2009)	2
RELA	1	AR	3	genetic interference, genetic interference	Aarnisalo P (1998), Aarnisalo P (1998)	2
MYC	2	TAF9	2	affinity chromatography technology, pull down	Liu X (2003), Liu X (2003)	2
ELF3	0	ISG15	0	affinity chromatography technology	Ewing RM (2007)	1
ELF3	0	TARS	2	affinity chromatography technology	Ewing RM (2007)	1
MED23	3	EP300	36	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
CALR	1	P4HB	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
XRCC5	5	GANAB	8	biochemical	Kristensen AR (2012)	1
AR	3	GADD45GIP1	0	affinity chromatography technology, two hybrid, pull down	Suh JH (2008), Suh JH (2008), Suh JH (2008)	3
AR	3	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Dai Y (2008), Minges JT (2013), Zhong J (2014), Fu M (2000), McClurg UL (2016), Tan G (2017)	6
ELF3	0	MED23	3	pull down, unspecified method, pull down, pull down, genetic interference, pull down	Asada S (2002), Asada S (2002), Shimogawa H (2004), Asada S (2003), Asada S (2002), Jeon KH (2013)	6
ISG15	0	XRCC6	3	affinity chromatography technology	Zhao C (2005)	1
RELA	1	MED23	3	pull down	Naeaer AM (1999)	1
ISG15	0	ATIC	6	affinity chromatography technology	Zhao C (2005)	1
ISG15	0	GANAB	8	affinity chromatography technology	Zhao C (2005)	1
SOX9	2	BTRC	1	affinity chromatography technology	Deng W (2015)	1
ELF3	0	CBR3	4	affinity chromatography technology	Wang H (2004)	1
TAF9	2	RELA	1	pull down	Buss H (2004)	1
ELF3	0	EHF	0	affinity chromatography technology	Ewing RM (2007)	1
RELA	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Spencer E (1999), Spencer E (1999), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	5
ELF3	0	EP300	36	affinity chromatography technology	Wang H (2004)	1
ISG15	0	XRCC5	5	affinity chromatography technology	Zhao C (2005)	1
ATIC	6	JAK1	6	affinity chromatography technology	Ewing RM (2007)	1
AR	3	XRCC5	5	pull down	Mayeur GL (2005)	1
GADD45GIP1	0	ELF3	0	affinity chromatography technology, imaging technique	Kwon MC (2009), Kwon MC (2009)	2
XRCC6	3	GANAB	8	biochemical	Kristensen AR (2012)	1
RELA	1	TBP	0	pull down, pull down, genetic interference, affinity chromatography technology	Guermah M (1998), Schmitz ML (1995), Schmitz ML (1995), Rojo-Niersbach E (2000)	4
MYC	2	RELA	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Chapman NR (2002), Covic M (2005), Ivanov AA (2017)	3
EP300	36	XRCC6	3	enzymatic study	Cohen HY (2004)	1
EHF	0	XRCC5	5	pull down, affinity chromatography technology	Wang H (2004), Wang H (2004)	2
ELF3	0	GANAB	8	affinity chromatography technology	Ewing RM (2007)	1
MYC	2	BTRC	1	affinity chromatography technology, enzymatic study	Popov N (2010), Popov N (2010)	2
ELF3	0	RELA	1	affinity chromatography technology	Longoni N (2013)	1
XRCC5	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Zhang Z (2017), Zhang Z (2017)	2
GANAB	8	P4HB	1	biochemical	Havugimana PC (2012)	1
ELF3	0	MYC	2	enzymatic study	Alvarez E (1991)	1
MYC	2	XRCC5	5	affinity chromatography technology	Koch HB (2007)	1
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
CALR	1	GANAB	8	biochemical	Havugimana PC (2012)	1
ERBB2	6	JAK1	6	unspecified method	Jones RB (2006)	1
AR	3	TBP	0	pull down	McEwan IJ (1997)	1
ELF3	0	JAK1	6	affinity chromatography technology	Ewing RM (2007)	1
ELF3	0	KRT31	0	affinity chromatography technology	Ewing RM (2007)	1
ELF3	0	ERBB2	6	genetic interference	Asada S (2002)	1
EEF1D	3	RELA	1	two hybrid	Wang J (2011)	1
ELF3	0	TAF9	2	pull down	Choi Y (2000)	1
ELF3	0	P4HB	1	affinity chromatography technology	Ewing RM (2007)	1
ELF3	0	EEF1D	3	affinity chromatography technology	Ewing RM (2007)	1
ELF3	0	SOX9	2	pull down	Otero M (2017)	1
ELF3	0	TBP	0	pull down	Chang CH (1999)	1
ELF3	0	ATIC	6	affinity chromatography technology	Ewing RM (2007)	1
PAK1	2	ELF3	0	enzymatic study, pull down	Manavathi B (2007), Manavathi B (2007)	2
ELF3	0	RPL6	0	affinity chromatography technology	Wang H (2004)	1
MYC	2	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Koch HB (2007)	2
MYC	2	GANAB	8	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2