Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CRTC2	200186	DACTOLISIB	CHEMBL1879463		ClearityFoundationClinicalTrial
CRTC2	200186	INK-128	CHEMBL3545056		TdgClinicalTrial
CRTC2	200186	GEDATOLISIB	CHEMBL592445		ClearityFoundationClinicalTrial
CRTC2	200186	VOXTALISIB	CHEMBL3545366		ClearityFoundationClinicalTrial

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CRTC2	rs8450	AA + AG	glucose	toxicity	yes	Increased fasting blood glucose (FBG) levels were seen in patients with the AA + AG genotypes as compared to the GG genotype.	Genotypes AA + AG are associated with increased concentrations of glucose in people with Transplantation as compared to genotype GG.	26644205	1448605357
CRTC2	rs8450	AA	hdl cholesterol	toxicity	yes	There was a discovery sample (patients received either tacrolimus or cyclosporine), and two replication samples from the Swiss Transplant Cohort Study (STCS; patients received tacrolimus, cyclosporine or neither). Significant results were found in the combined STCS replication samples. No association with total or LDL cholesterol levels were seen.	Genotype AA is associated with decreased concentrations of hdl cholesterol in people with Transplantation as compared to genotypes AG + GG.	26644205	1448605470
CRTC2	rs12117078	GG	glucose	toxicity	no	No association with fasting blood glucose (FBG) levels was seen between the genotypes.	Genotype GG is not associated with concentrations of glucose in people with Transplantation as compared to genotypes CC + CG.	26644205	1448605395