PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POLB	0	HIST2H2AB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFY	1	TOP1	1	affinity chromatography technology	Ouararhni K (2006)	1
HIST1H2BA	0	HIST1H2BJ	3	affinity chromatography technology	Huttlin EL (2015)	1
H2AFY	1	APP	1	pull down	Olah J (2011)	1
APLF	3	440686	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPC	1	H2AFY2	0	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	MSH3	4	affinity chromatography technology	Huttlin EL (2017)	1
CHD1L	5	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	APP	1	pull down	Olah J (2011)	1
PARP1	3	APLF	3	pull down, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kanno S (2007), Kanno S (2007), Eustermann S (2010), Ahel I (2008), Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	7
XRCC4	0	LIG4	0	two hybrid, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Deshpande RA (2007), Deshpande RA (2007), Sibanda BL (2001), Drouet J (2005), Huang J (2002), Nick McElhinny SA (2000), Wang YG (2004), Wang YG (2004), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	11
XPC	1	CETN2	0	biochemical, pull down, affinity chromatography technology, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Araki M (2001), Araki M (2001), Bunick CG (2006), Havugimana PC (2012), Gupta GD (2015), Huttlin EL (2017), Lan X (2016)	7
POLB	0	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARP1	3	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Sand-Dejmek J (2011), Wu T (2013)	11
SUPT16H	4	TOP1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CST1	0	CST4	0	affinity chromatography technology	Huttlin EL (2017)	1
XRCC5	5	TOP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sand-Dejmek J (2011), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	5
POLB	0	TDP1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFY2	0	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H2BA	0	PARP1	3	pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2010), Huttlin EL (2015), Huttlin EL (2017)	3
PARP2	0	HIST3H3	0	enzymatic study	Bonfiglio JJ (2017)	1
APLF	3	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFY2	0	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
POLB	0	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APLF	3	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	3
APP	1	HIST2H2AC	1	pull down	Virok DP (2011)	1
HIST2H2AC	1	HIST1H2BA	0	pull down, pull down	Hoffmann A (1996), Boenisch C (2012)	2
CHD1L	5	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
XRCC4	0	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Drouet J (2005), Drouet J (2005)	2
HIST3H3	0	H2AFY	1	affinity chromatography technology	Chen H (2014)	1
PARP1	3	SUPT16H	4	enzymatic study	Huang JY (2006)	1
XRCC6	3	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	7515	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gueven N (2004), Gueven N (2004), Masson M (1998), Masson M (1998), Cazzalini O (2010), Lee CH (2010), Leppard JB (2003)	7
XPC	1	HIST1H2AG	1	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	H2AFY	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	3
APLF	3	PARP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	CETN2	0	affinity chromatography technology	Huttlin EL (2015)	1
HIST1H2BA	0	H2AFY2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPC	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
XRCC6	3	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
LIG4	0	APLF	3	pull down, affinity chromatography technology, affinity chromatography technology	Kanno S (2007), Huttlin EL (2015), Huttlin EL (2017)	3
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
APLF	3	HIST1H2BJ	3	affinity chromatography technology	Huttlin EL (2015)	1
HIST1H2BA	0	HIST2H2AB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPC	1	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	HLTF	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H2BA	0	SSRP1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
XRCC6	3	H2AFY	1	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H2BA	0	CHD1L	5	affinity chromatography technology	Huttlin EL (2015)	1
APLF	3	CETN2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H2BA	0	APLF	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIG3	6	XRCC6	3	affinity chromatography technology, pull down, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Huttlin EL (2017)	3
APLF	3	CST1	0	affinity chromatography technology	Huttlin EL (2017)	1
CHD1L	5	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Huttlin EL (2017)	2
PARP1	3	HIST3H3	0	enzymatic study	Bonfiglio JJ (2017)	1
CHD1L	5	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009), Brockschmidt A (2011), Kulkarni A (2013), Huttlin EL (2017)	5
HIST1H2BA	0	HLTF	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHD1L	5	HLTF	7	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H2BA	0	PARP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XRCC6	3	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
POLB	0	SSRP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H2BA	0	7515	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
POLB	0	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APLF	3	HIST1H2AG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIG3	6	PARP1	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Leppard JB (2003), Leppard JB (2003)	4
H2AFY2	0	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
XRCC6	3	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
XRCC6	3	7515	0	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	CST4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H2BA	0	HIST1H2AG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APLF	3	HIST3H3	0	affinity chromatography technology, affinity chromatography technology	Mehrotra PV (2011), Gibbs-Seymour I (2016)	2
FBXO25	1	APLF	3	enzymatic study	Teixeira FR (2013)	1
TOP1	1	LIG4	0	unspecified method	Trzcinska AM (2002)	1
H2AFY	1	XRCC5	5	affinity chromatography technology	Ouararhni K (2006)	1
CHD1L	5	7515	0	affinity chromatography technology, affinity chromatography technology	Ahel D (2009), Huttlin EL (2017)	2
XRCC6	3	LIG4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Drouet J (2005), Nick McElhinny SA (2000), Woods NT (2012), Hein MY (2015)	4
APLF	3	TDP1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHD1L	5	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009), Ahel D (2009), Kulkarni A (2013), Huttlin EL (2017)	5
XRCC5	5	SSRP1	1	affinity chromatography technology, imaging technique	Sand-Dejmek J (2011), Sand-Dejmek J (2011)	2
POLB	0	PARP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOP1	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	4
PARP1	3	CETN2	0	affinity chromatography technology	Wu T (2013)	1
7515	0	LIG3	6	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Ewing RM (2007), Caldecott KW (1994), Nash RA (1997), Dulic A (2001), Taylor RM (1998), Ogi T (2010), Hein MY (2015)	8
HIST1H2BA	0	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPC	1	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	SSRP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XRCC5	5	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Sand-Dejmek J (2011), Sand-Dejmek J (2011)	2
PARP1	3	POLB	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Huttlin EL (2015), Huttlin EL (2017)	5
XRCC5	5	APLF	3	pull down, affinity chromatography technology, affinity chromatography technology	Kanno S (2007), Huttlin EL (2015), Huttlin EL (2017)	3
H2AFY2	0	H2AFY	1	affinity chromatography technology	Huttlin EL (2017)	1
XRCC5	5	LIG4	0	affinity chromatography technology, affinity chromatography technology	Drouet J (2005), Nick McElhinny SA (2000)	2
CHD1L	5	APLF	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahel D (2009), Kulkarni A (2013), Huttlin EL (2015), Huttlin EL (2017)	4
APLF	3	H2AFY2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPC	1	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H2BA	0	H2AFY	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XRCC4	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Drouet J (2005), Drouet J (2005), Hein MY (2015)	3
HIST1H2BA	0	APP	1	pull down	Olah J (2011)	1
APLF	3	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSRP1	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
POLB	0	7515	0	two hybrid, pull down, pull down, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang L (2004), Fan J (2004), Kubota Y (1996), Kubota Y (1996), Bhattacharyya N (2001), Bhattacharyya N (2001), Luo H (2004), Huttlin EL (2015), Hein MY (2015), Fang Q (2014), Fang Q (2014), Huttlin EL (2017)	12
TDP1	5	LIG3	6	affinity chromatography technology	Fam HK (2018)	1
HIST1H2BA	0	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARP1	3	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Wu T (2013), Huttlin EL (2017)	11
CHD1L	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009)	2
APLF	3	XRCC4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOP1	1	PARP1	3	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, biochemical	Czubaty A (2005), Yung TM (2004), Yung TM (2004), Yung TM (2004), Yung TM (2004)	5
APLF	3	7515	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	3
SSRP1	1	HIST2H2AC	1	pull down	Winkler DD (2011)	1
GMCL1	0	APLF	3	two hybrid	Rolland T (2014)	1
POLB	0	APLF	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIG3	6	APP	1	pull down	Olah J (2011)	1
7515	0	PARP2	0	affinity chromatography technology, affinity chromatography technology	Schreiber V (2002), Schreiber V (2002)	2
SSRP1	1	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	PARP2	0	affinity chromatography technology	Schreiber V (2002)	1
SSRP1	1	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2017)	1
CHD1L	5	PARP2	0	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Huttlin EL (2017)	2
HIST2H2AB	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
POLB	0	HIST1H2AG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H2BA	0	CETN2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFY2	0	440686	0	affinity chromatography technology	Huttlin EL (2017)	1
H2AFY	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Ouararhni K (2006), Nusinow DA (2007), Nusinow DA (2007), Nusinow DA (2007), Chen H (2014), Sarma K (2014), Sarma K (2014), Forst AH (2013)	8
APLF	3	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOP1	1	APP	1	pull down	Olah J (2011)	1
APLF	3	TOP1	1	affinity chromatography technology	Huttlin EL (2015)	1
APLF	3	ZG16B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIG3	6	XRCC5	5	affinity chromatography technology, pull down	Leppard JB (2003), Leppard JB (2003)	2
APLF	3	HIST2H2AB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H2BA	0	SUPT16H	4	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
XPC	1	H2AFY	1	affinity chromatography technology	Huttlin EL (2017)	1
H2AFY2	0	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	HIST2H2AC	1	affinity chromatography technology	Gibbs-Seymour I (2016)	1