PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH2	4	SKP1	0	affinity chromatography technology	Chung FZ (2014)	1
CUL1	7	USP11	3	affinity chromatography technology	Bennett EJ (2010)	1
NOS2	6	MYCBP2	11	affinity chromatography technology	Foster MW (2013)	1
NEURL4	3	MYCBP2	11	affinity chromatography technology	Boldt K (2016)	1
STAT2	2	FBXO45	1	affinity chromatography technology	Huttlin EL (2017)	1
STAT2	2	MYCBP2	11	affinity chromatography technology	Huttlin EL (2017)	1
CDH19	2	FBXO45	1	affinity chromatography technology	Huttlin EL (2017)	1
HEYL	1	FBXO45	1	affinity chromatography technology	Salat D (2015)	1
TP73	2	CUL1	7	affinity chromatography technology	Peschiaroli A (2009)	1
FBXO45	1	GALC	6	affinity chromatography technology	Boldt K (2016)	1
FBXO45	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Chung FZ (2014), Chung FZ (2014)	2
SKP1	0	ESR1	0	affinity chromatography technology	Zhou W (2014)	1
YWHAH	0	FBXO45	1	affinity chromatography technology	Hein MY (2015)	1
CDH2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Straub BK (2003), Wahl JK (2003), Fischer L (2002), Sadot E (2002), Chung FZ (2014), Boscher C (2008)	6
FBXO45	1	PAWR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Chen X (2014), Chen X (2014), Chen X (2014), Chen X (2014), Chen X (2014), Hebbar N (2017)	6
CUL1	7	FBXO45	1	affinity chromatography technology	Reitsma JM (2017)	1
NOS2	6	LGALS3BP	5	affinity chromatography technology	Foster MW (2013)	1
EGLN3	0	MYCBP2	11	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	SKP1	0	affinity chromatography technology	Rodriguez J (2016)	1
HEY2	0	HEY1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Huang CH (2013), Huang CH (2013), Huttlin EL (2015), Huttlin EL (2017), Villaronga MA (2010), Lopez-Mateo I (2016)	6
CDH19	2	MYCBP2	11	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	FBXO45	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Han SJ (2016), Han SJ (2016), Han SJ (2016)	3
HEY2	0	FBXO45	1	affinity chromatography technology	Salat D (2015)	1
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
SKP1	0	MYCBP2	11	affinity chromatography technology	Hauri S (2016)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
LGALS3BP	5	FBXO45	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CTNNB1	30	ESR1	0	affinity chromatography technology	Kouzmenko AP (2004)	1
FBXO45	1	RFC4	1	affinity chromatography technology	Boldt K (2016)	1
TP73	2	FBXO45	1	affinity chromatography technology, enzymatic study	Peschiaroli A (2009), Peschiaroli A (2009)	2
EGLN3	0	FBXO45	1	affinity chromatography technology	Rodriguez J (2016)	1
FBXO45	1	CDH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chung FZ (2014), Chung FZ (2014), Chung FZ (2014)	3
CUL1	7	ESR1	0	affinity chromatography technology	Zhou W (2014)	1
FBXO45	1	NEURL4	3	affinity chromatography technology	Boldt K (2016)	1
CUL1	7	LGALS3BP	5	affinity chromatography technology	Bennett EJ (2010)	1
LGALS3BP	5	NEURL4	3	affinity chromatography technology	Huttlin EL (2017)	1
LGALS3BP	5	MYCBP2	11	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
NOS2	6	FBXO45	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foster MW (2013), Foster MW (2013), Foster MW (2013)	3
HEY1	2	MYCBP2	11	affinity chromatography technology	Salat D (2015)	1
HEY1	2	FBXO45	1	affinity chromatography technology, imaging technique	Salat D (2015), Salat D (2015)	2
GALC	6	NEURL4	3	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
YWHAH	0	MYCBP2	11	affinity chromatography technology	Hein MY (2015)	1
CLEC11A	0	MYCBP2	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HEY1	2	SKP1	0	affinity chromatography technology	Salat D (2015)	1
FBXO45	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saiga T (2009), Chen X (2014), Chen X (2014), Chen X (2014), Chung FZ (2014), Chung FZ (2014), Hauri S (2016)	7
GDF10	3	FBXO45	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXW7	2	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu G (2001), Tron AE (2012), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Bennett EJ (2010), Strohmaier H (2001), Davis MA (2013), JunGang Z (2012), Busino L (2003), Pierce NW (2013), Chung FZ (2014), Yumimoto K (2012), Low TY (2014), Kourtis N (2015), Gorelik M (2016), Gorelik M (2016), Huttlin EL (2017), Reiterer V (2017), Reiterer V (2017), Ye M (2017), Reitsma JM (2017)	23
CTNNB1	30	CUL1	7	affinity chromatography technology	Read MA (2000)	1
NEURL4	3	RFC4	1	affinity chromatography technology	Boldt K (2016)	1
FBXW7	2	FBXO45	1	affinity chromatography technology, affinity chromatography technology	Kourtis N (2015), Huttlin EL (2017)	2
CLEC11A	0	GALC	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOS2	6	SKP1	0	affinity chromatography technology	Foster MW (2013)	1
GDF10	3	MYCBP2	11	affinity chromatography technology	Huttlin EL (2017)	1
SKP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017)	28
FBXW7	2	CDH19	2	genetic interference	Bailey ML (2015)	1
USP11	3	MYCBP2	11	affinity chromatography technology	Sowa ME (2009)	1
CTNNB1	30	SKP1	0	affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique	Matsuzawa SI (2001), Winston JT (1999), Wang D (2011), Chen TC (2014)	4
FBXO45	1	MYCBP2	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saiga T (2009), Saiga T (2009), Chen X (2014), Chen X (2014), Chen X (2014), Chung FZ (2014), Chung FZ (2014), Chung FZ (2014), Boldt K (2016)	9
FBXW7	2	MYCBP2	11	affinity chromatography technology, affinity chromatography technology	Kourtis N (2015), Huttlin EL (2017)	2
CLEC11A	0	FBXO45	1	affinity chromatography technology	Huttlin EL (2017)	1
USP11	3	FBXO45	1	affinity chromatography technology	Sowa ME (2009)	1