PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
SPATA24	0	DCAF17	0	affinity chromatography technology	Huttlin EL (2017)	1
SPATA24	0	ISCA1	0	affinity chromatography technology	Huttlin EL (2017)	1
ODF2	1	TRIM9	3	bioid	Gupta GD (2015)	1
LCA5	1	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
ODF2	1	CEP72	0	bioid	Gupta GD (2015)	1
FLOT2	1	SPATA24	0	two hybrid	Wang J (2011)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
SPATA24	0	GGPS1	0	affinity chromatography technology	Huttlin EL (2017)	1
SPATA24	0	KDM1A	2	two hybrid	Weimann M (2013)	1
CEP135	2	CEP72	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CDR2	1	SPATA24	0	affinity chromatography technology	Huttlin EL (2017)	1
MID2	1	SPATA24	0	two hybrid	Rolland T (2014)	1
CEP128	1	IQCB1	3	bioid	Gupta GD (2015)	1
CAMK2D	3	SPATA24	0	two hybrid	Wang J (2011)	1
SPATA24	0	THNSL1	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	LZTS2	4	bioid	Gupta GD (2015)	1
CEP63	2	SPATA24	0	bioid	Gupta GD (2015)	1
SPATA24	0	STXBP2	6	affinity chromatography technology	Huttlin EL (2017)	1
SPATA24	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
LCA5	1	CEP162	3	bioid	Gupta GD (2015)	1
SPATA24	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
CEP162	3	SPATA24	0	bioid	Gupta GD (2015)	1
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
SPATA24	0	DHPS	3	affinity chromatography technology	Huttlin EL (2017)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
PCM1	5	CEP72	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, bioid	Rual JF (2005), Xin X (2009), Fogeron ML (2013), Gupta GD (2015), Gupta GD (2015)	5
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
LCA5	1	CEP72	0	bioid	Gupta GD (2015)	1
CEP162	3	IQCB1	3	affinity chromatography technology	Gupta GD (2015)	1
CEP128	1	SPATA24	0	bioid	Gupta GD (2015)	1
SPATA24	0	DCAF5	1	affinity chromatography technology	Huttlin EL (2017)	1
ODF2	1	SPATA24	0	bioid	Gupta GD (2015)	1
CALCOCO2	0	SPATA24	0	two hybrid	Rolland T (2014)	1
CEP135	2	SPATA24	0	bioid	Gupta GD (2015)	1
SPATA24	0	80273	0	affinity chromatography technology	Huttlin EL (2017)	1
MID2	1	CEP128	1	affinity chromatography technology	Gholkar AA (2016)	1
PCM1	5	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
LZTS2	4	ISCA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPATA24	0	RBM26	3	affinity chromatography technology	Huttlin EL (2017)	1
LCA5	1	SPATA24	0	bioid	Gupta GD (2015)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
IQCB1	3	SPATA24	0	affinity chromatography technology	Sang L (2011)	1
CEP63	2	CEP72	0	bioid	Gupta GD (2015)	1
PCM1	5	IQCB1	3	bioid	Gupta GD (2015)	1
EHD2	3	SPATA24	0	two hybrid	Wang J (2011)	1
IQCB1	3	CALCOCO2	0	affinity chromatography technology	Sang L (2011)	1
CEP128	1	TRIM9	3	bioid	Gupta GD (2015)	1
CALCOCO2	0	MID2	1	two hybrid	Rolland T (2014)	1
CEP135	2	LZTS2	4	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	LZTS2	4	bioid	Gupta GD (2015)	1
CEP128	1	CEP72	0	bioid	Gupta GD (2015)	1
SPATA24	0	TRIM9	3	affinity chromatography technology	Huttlin EL (2017)	1
KRT40	0	SPATA24	0	two hybrid	Rolland T (2014)	1
CEP72	0	SPATA24	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
SPATA24	0	UBR1	3	affinity chromatography technology	Huttlin EL (2017)	1
CEP63	2	LZTS2	4	bioid	Firat-Karalar EN (2014)	1
PCM1	5	CEP63	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP162	3	CEP72	0	bioid	Gupta GD (2015)	1
KRTAP4-2	0	SPATA24	0	two hybrid	Rolland T (2014)	1
KRT31	0	SPATA24	0	two hybrid	Rolland T (2014)	1
SUV39H1	0	LZTS2	4	two hybrid	Rolland T (2014)	1
PTAFR	1	SPATA24	0	two hybrid	Wang J (2011)	1
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	SPATA24	0	bioid	Gupta GD (2015)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
LZTS2	4	SPATA24	0	two hybrid	Rolland T (2014)	1
CEP162	3	KDM1A	2	two hybrid	Weimann M (2013)	1