PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ENG	5	ACVR2B	0	affinity chromatography technology	Barbara NP (1999)	1
TGFBR2	0	ACVR1	4	two hybrid	Kawabata M (1995)	1
ENG	5	TGFB1	2	affinity chromatography technology	Cheifetz S (1992)	1
BMP7	3	ACVR2B	0	affinity chromatography technology	Macias-Silva M (1998)	1
ENG	5	TGFB3	0	affinity chromatography technology	Cheifetz S (1992)	1
TGFBR2	0	ACVR2A	0	affinity chromatography technology	Huttlin EL (2015)	1
TGFBR2	0	ACVR2B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TUFM	1	ENG	5	biochemical	Havugimana PC (2012)	1
ACVRL1	1	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Oh SP (2000), Attisano L (1993)	2
ENG	5	ENG	5	biochemical	Lastres P (1992)	1
TGFBR1	2	TGFB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Ebner R (1993), Oh SP (2000), Wakahara K (2005)	3
TGFBR2	0	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Rotzer D (2001), Attisano L (1993)	2
ACVR1	4	ACVR2A	0	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
ENG	5	BMP7	3	affinity chromatography technology	Barbara NP (1999)	1
BMP7	3	ACVR2A	0	affinity chromatography technology	Macias-Silva M (1998)	1
ENG	5	ACVR1	4	affinity chromatography technology	Barbara NP (1999)	1
ENG	5	ACVR2A	0	affinity chromatography technology	Barbara NP (1999)	1
TGFB3	0	TGFBR2	0	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	De Crescenzo G (2003), Hart PJ (2002), Barbara NP (1999), Rotzer D (2001)	4
TGFBR1	2	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Blanco FJ (2008), Blanco FJ (2008), Blanco FJ (2005)	7
ENG	5	BMP2	2	affinity chromatography technology	Barbara NP (1999)	1
BMP7	3	ACVR1	4	pull down	ten Dijke P (1994)	1
TGFBR2	0	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Barbara NP (1999), Blanco FJ (2005)	6
ACVRL1	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
ACVR1	4	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ENG	5	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Blanco FJ (2005), Blanco FJ (2005)	2