PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
NCK1	0	EPHB1	9	two hybrid, affinity chromatography technology	Stein E (1998), Stein E (1998)	2
CBL	7	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Erdreich-Epstein A (1999), Miyoshi-Akiyama T (2001), Izadi KD (1998), Izadi KD (1998), Wunderlich L (1999), Shishido T (2000), Okabe S (2006), Adler CE (2000), Adler CE (2000), Buvall L (2013), Buvall L (2013), Buvall L (2013), Buvall L (2013)	13
DNMT3B	3	EPHB1	9	affinity chromatography technology	Hervouet E (2009)	1
PRKCG	3	EPHB1	9	pull down	Rex EB (2010)	1
HSP90AA1	7	EPHB1	9	affinity chromatography technology	Taipale M (2012)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CBL	7	EPHB1	9	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Fasen K (2008), Fasen K (2008), Fasen K (2008), Fasen K (2008), Rodriguez S (2013), Rodriguez S (2013)	6
GRB7	1	EPHB1	9	two hybrid, affinity chromatography technology	Han DC (2002), Han DC (2002)	2
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
EFNA5	1	EPHB1	9	pull down	Kozlosky CJ (1997)	1
CBL	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
EPHB1	9	GRB2	2	two hybrid	Stein E (1996)	1
PTEN	24	EPHB1	9	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
HSP90AA1	7	PRKCG	3	affinity chromatography technology	Taipale M (2012)	1
PTEN	24	HSP90AA1	7	affinity chromatography technology, genetic interference	Maddika S (2011), Shen JP (2017)	2
SLC9A3R1	2	EPHB1	9	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
KLRG2	2	EPHB1	9	affinity chromatography technology	Huttlin EL (2017)	1
EPHB1	9	GRB10	4	two hybrid	Stein E (1996)	1
EPHB1	9	ACP1	4	affinity chromatography technology, pull down	Stein E (1998), Stein E (1998)	2
PTEN	24	SLC9A3R1	2	affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology	Yang L (2011), Yang L (2011), Rodriguez S (2013), Molina JR (2012), Molina JR (2012), Zheng J (2016)	6