PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HMMR	1	EPHB2	10	affinity chromatography technology	Park D (2012)	1
CRK	0	ABL2	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, two hybrid	Brehme M (2009), Feller SM (1994), Feller SM (1994), Hu H (2005), Grossmann A (2015)	5
EPHB2	10	STK26	0	genetic interference	Lin JL (2001)	1
ABL1	9	PLCG1	6	pull down	Koch A (2000)	1
AFDN	10	EPHB2	10	two hybrid	Hock B (1998)	1
EPHB2	10	KDM4A	3	biochemical	Wan C (2015)	1
EPHB2	10	MTMR14	4	two hybrid	Yao Z (2017)	1
PLCG1	6	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jabado N (1998), Jabado N (1997), Jabado N (1997)	3
RASA1	3	ABL1	9	affinity chromatography technology	Druker B (1992)	1
EPHB2	10	EPHB2	10	x-ray crystallography, enzymatic study	Thanos CD (1999), Chang Q (2008)	2
EPHB2	10	ABL2	4	two hybrid	Yu HH (2001)	1
ABL1	9	ABL2	4	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Cao C (2003), Cao C (2003), Cao C (2003), Cao C (2005)	4
ALK	8	EPHB2	10	affinity chromatography technology	Crockett DK (2004)	1
SPSB2	0	EPHB2	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRK	0	EPHB2	10	pull down	Zisch AH (2000)	1
ABL1	9	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, two hybrid, enzymatic study	Brehme M (2009), Brehme M (2009), Brehme M (2009), Peterson ME (2008), Yoshida K (2005), Chen C (2008), Feller SM (1994), Feller SM (1994), Bai RY (1998), Ren J (2002)	10
PLCG1	6	ALK	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bonvini P (2002), Crockett DK (2004), Crockett DK (2004), Bai RY (1998), Bai RY (1998)	5
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
RASA1	3	SRC	2	affinity chromatography technology, enzymatic study	Brott BK (1991), Giglione C (2001)	2
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
ALK	8	SRC	2	affinity chromatography technology	Ambrogio C (2005)	1
FBXO7	1	ABL1	9	enzymatic study	Teixeira FR (2016)	1
SRC	2	EPHB2	10	two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, pull down	Zisch AH (1998), Zisch AH (2000), Zisch AH (2000), Zisch AH (1998), Zisch AH (1998), Zisch AH (1998)	6
EPHB2	10	YES1	1	pull down	Zisch AH (1998)	1
EPHB2	10	ACP1	4	affinity chromatography technology	Stein E (1998)	1
FBXO7	1	EPHB2	10	enzymatic study	Teixeira FR (2016)	1
EPHB2	10	ABL1	9	affinity chromatography technology, pull down, two hybrid	Yu HH (2001), Yu HH (2001), Yu HH (2001)	3
RYK	1	EPHB2	10	affinity chromatography technology	Trivier E (2002)	1
ITSN1	5	EPHB2	10	affinity chromatography technology	Irie F (2002)	1
EPHB2	10	PLCG1	6	two hybrid	Zisch AH (1998)	1
EPHB2	10	RASA1	3	affinity chromatography technology, pull down, pull down	Holland SJ (1997), Holland SJ (1997), Zisch AH (2000)	3
RASA1	3	YES1	1	affinity chromatography technology	Cichowski K (1992)	1
EPHB2	10	EFNB2	0	pull down, affinity chromatography technology, affinity chromatography technology	Himanen JP (2002), Huttlin EL (2015), Huttlin EL (2017)	3
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2