PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	EPO	0	two hybrid	Wang J (2011)	1
EPO	0	GINM1	1	affinity chromatography technology	Huttlin EL (2017)	1
USF2	3	EPO	0	imaging technique	Pawlus MR (2013)	1
EPO	0	EPOR	3	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Middleton SA (1999), Livnah O (1998), Meyer L (2007), Walrafen P (2005), Huttlin EL (2017)	5
EP300	36	USF2	3	two hybrid	Breen GA (1999)	1