PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
INPP5D	2	LYN	2	affinity chromatography technology, pull down	Baran CP (2003), Baran CP (2003)	2
FBXW7	2	EPOR	3	genetic interference	Bailey ML (2015)	1
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
SRC	2	EPOR	3	affinity chromatography technology	Liang K (2010)	1
SYK	3	INPP5D	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012), de Castro RO (2012)	3
SHC1	0	EPOR	3	affinity chromatography technology	Damen JE (1993)	1
SRC	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Burnham MR (1999), Song JJ (2010), Liu W (2010), Chen TC (2014)	4
RACK1	2	ELOB	1	pull down	Liu YV (2007)	1
EGLN3	0	NOSIP	2	affinity chromatography technology	Rodriguez J (2016)	1
SRC	2	RACK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chang BY (1998), Chang BY (1998), Chang BY (1998), Chang BY (1998), Chen S (2008)	5
EPOR	3	SH2B2	1	pull down	Wakioka T (1999)	1
LYN	2	PTPN6	0	pull down	Yoshida K (1999)	1
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
CISH	1	ELOC	0	affinity chromatography technology	Lavens D (2007)	1
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
STAT5A	4	JAK2	1	affinity chromatography technology, two hybrid, pull down, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Fujitani Y (1997), Gouilleux F (1994)	4
EPOR	3	ELOC	0	pull down	Heir P (2016)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
JAK2	1	EPOR	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Huang LJ (2001), Huang LJ (2001), Witthuhn BA (1993), van den Akker E (2004)	4
FBXW7	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, pull down	Song Y (2017), Song Y (2017), Song Y (2017)	3
IRS2	6	GRB2	2	unspecified method, affinity chromatography technology	Liu BA (2012), Bisson N (2011)	2
PIK3R1	6	INPP5D	2	affinity chromatography technology	Zhang S (1999)	1
EPOR	3	GRB2	2	pull down, pull down, affinity chromatography technology	Tauchi T (1995), Feng GS (1996), Barber DL (1997)	3
RACK1	2	ELOC	0	affinity chromatography technology, pull down, affinity chromatography technology	Subauste MC (2009), Liu YV (2007), Liu YV (2007)	3
PTPN6	0	PIK3R1	6	two hybrid	Sathish JG (2001)	1
EPOR	3	SYK	3	affinity chromatography technology	Duprez V (1998)	1
CISH	1	RACK1	2	affinity chromatography technology	Zhang W (2008)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
IRS2	6	EPOR	3	affinity chromatography technology	Verdier F (1997)	1
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
PTPN11	20	STAT5A	4	pull down, enzymatic study, affinity chromatography technology	Yu CL (2000), Yu CL (2000), Chughtai N (2002)	3
VHL	0	EPOR	3	affinity chromatography technology, affinity chromatography technology, pull down	Heir P (2016), Heir P (2016), Heir P (2016)	3
BTRC	1	EPOR	3	affinity chromatography technology	Meyer L (2007)	1
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
MST1R	4	SHC1	0	affinity chromatography technology	Iwama A (1996)	1
PIK3R1	6	JAK2	1	pull down, genetic interference	Ren SY (2005), Shen JP (2017)	2
VAV1	2	PTPN6	0	pull down	Kon-Kozlowski M (1996)	1
EGLN3	0	ELOB	1	affinity chromatography technology	Rodriguez J (2016)	1
PLCG1	6	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
RACK1	2	PLCG1	6	far western blotting	Disatnik MH (1994)	1
EPOR	3	ATXN2L	4	affinity chromatography technology	Meunier C (2002)	1
CISH	1	ELOB	1	affinity chromatography technology	Lavens D (2007)	1
CBL	7	MST1R	4	affinity chromatography technology, affinity chromatography technology	Germano S (2006), Penengo L (2003)	2
VHL	0	ELOB	1	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Ohh M (1999), Min JH (2002), Hacker KE (2008), Menon S (2008), Kamura T (2002), Kamura T (2002), Kuznetsova AV (2003), Cockman ME (2000), Sufan RI (2009), Stickle NH (2004), Lai Y (2011), Norman JA (2006), Kinoshita K (2007), Lai Y (2012), Mahrour N (2008), Mahrour N (2008), Grosfeld A (2007), Foxler DE (2012), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017)	43
EGLN3	0	CRKL	1	affinity chromatography technology	Rodriguez J (2016)	1
SOCS3	0	ELOC	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Zhang WN (2012), Haan S (2003), Haan S (2003), Kamura T (2004)	5
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
SYK	3	PIK3R1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Moon KD (2005), Moon KD (2005), Moon KD (2005), Moon KD (2005), Huang ZY (2006)	5
STAT5A	4	CBL	7	affinity chromatography technology, two hybrid	Dieudonne FX (2013), Grossmann A (2015)	2
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
SOCS3	0	ELOB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao Z (2007), Niwa Y (2005), Kamura T (2004)	3
CRKL	1	PTPN11	20	affinity chromatography technology	Chin H (1997)	1
CRKL	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down	Gesbert F (1998), Gelkop S (2001), Ren SY (2005)	3
SOCS2	1	ELOC	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical	Vesterlund M (2011), Lievens S (2009), Lievens S (2009), Kim DY (2013)	4
LYN	2	JAK2	1	pull down	Chin H (1998)	1
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
VAV1	2	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Bertagnolo V (1998), Bertagnolo V (1998), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
FBXW7	2	RACK1	2	affinity chromatography technology, pull down	Zhang J (2011), Zhang J (2011)	2
SRC	2	JAK2	1	affinity chromatography technology	Liang K (2010)	1
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
CBL	7	PTPN6	0	affinity chromatography technology	Kant AM (2002)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
EPOR	3	SOCS2	1	two hybrid, affinity chromatography technology, protein complementation assay, pull down, protein complementation assay, unspecified method	Eyckerman S (2001), Eyckerman S (2001), Lavens D (2007), Lavens D (2007), Montoye T (2005), Bullock AN (2006)	6
IRS2	6	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Argetsinger LS (1996), Verdier F (1997), Kim B (1998), Hamer I (2002), Calegari VC (2005), Tzatsos A (2009), Ren W (2013), Hein MY (2015)	8
IRS2	6	PTPN11	20	affinity chromatography technology	Argetsinger LS (1996)	1
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
JAK2	1	VAV1	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Matsuguchi T (1995)	3
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
EGLN3	0	IRS2	6	affinity chromatography technology	Rodriguez J (2016)	1
GRB2	2	MST1R	4	pull down, affinity chromatography technology	Li BQ (1995), Iwama A (1996)	2
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
NOSIP	2	EPOR	3	affinity chromatography technology	Friedman AD (2003)	1
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
CISH	1	EPOR	3	affinity chromatography technology, protein complementation assay, pull down, protein complementation assay	Yoshimura A (1995), Lavens D (2007), Lavens D (2007), Montoye T (2005)	4
SOCS3	0	SOCS2	1	affinity chromatography technology	Tannahill GM (2005)	1
EPO	0	EPOR	3	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Middleton SA (1999), Livnah O (1998), Meyer L (2007), Walrafen P (2005), Huttlin EL (2017)	5
IRS2	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Calegari VC (2005), Calegari VC (2005)	2
CRKL	1	SYK	3	affinity chromatography technology, pull down	Oda A (2001), Oda A (2001)	2
SH2B2	1	SHC1	0	pull down	Yokouchi M (1997)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
CBL	7	VAV1	2	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Bertagnolo V (2001), Miura-Shimura Y (2003), Simmons A (2005), Shen M (2009), Shen M (2009), Lottin-Divoux S (2006), Lottin-Divoux S (2006), Peterson ME (2008)	12
CRKL	1	SHC1	0	affinity chromatography technology	Chin H (1997)	1
VHL	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Kamura T (2001), Hacker KE (2008), Hacker KE (2008), Menon S (2008), Chew EH (2007), Ietta F (2006), Megumi Y (2005), Kamura T (2002), Kuznetsova AV (2003), Hansen WJ (2002), Cockman ME (2000), Lisztwan J (1999), Lisztwan J (1999), Sufan RI (2006), Sufan RI (2009), Stickle NH (2004), Lai Y (2011), Norman JA (2006), Knauth K (2006), Lonergan KM (1998), Lai Y (2012), Miller F (2005), Mahrour N (2008), Grosfeld A (2007), Russell RC (2011), Foxler DE (2012), Bonicalzi ME (2001), Bennett EJ (2010), Kanaya K (2002), Liakopoulos D (1999), Pause A (1997), Pause A (1997), Pause A (1997), Iliopoulos O (1998), Pause A (1999), Pause A (1999), Xin H (2011), Kamura T (2004), Kamura T (2004), Heir P (2013), Russell RC (2008), Russell RC (2008), Essers PB (2014), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Heir P (2016), Chen K (2016), Uematsu K (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	54
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
JAK2	1	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
SRC	2	PTPN11	20	enzymatic study	Vogel W (1996)	1
CBL	7	SYK	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Lupher ML (1998), Lupher ML (1998), Bertagnolo V (2001), Melander F (2003), Macglashan D (2004), Rao N (2001), Rao N (2001), Yankee TM (1999), Saci A (2000), Moon KD (2005), Lottin-Divoux S (2006), Grossmann AH (2004), Ota S (2000), Ota S (2000), Panchamoorthy G (1996), Marcilla A (1995), Justa-Schuch D (2016)	17
PIK3R1	6	EPOR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Damen JE (1995), Damen JE (1995), Montoye T (2005), Bulut GB (2013)	6
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
CUL2	3	ELOB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kamura T (2001), Menon S (2008), Megumi Y (2005), Kamura T (2002), Brower CS (2002), Bennett EJ (2010), Pause A (1997), Kamura T (2004), Kelsall IR (2013)	9
SHC1	0	STAT5A	4	affinity chromatography technology	Dinerstein-Cali H (2000)	1
PTPN6	0	SYK	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ganju RK (2000), Dustin LB (1999), Dustin LB (1999)	3
GRAP	0	EPOR	3	pull down	Feng GS (1996)	1
EGLN3	0	ELOC	0	affinity chromatography technology	Rodriguez J (2016)	1
CUL2	3	CISH	1	affinity chromatography technology	Zhang W (2008)	1
JAK2	1	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Jiao H (1996), Wu DW (2000)	2
JAK2	1	SH2B2	1	enzymatic study	Wakioka T (1999)	1
LYN	2	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Taher TE (2002), Dombrosky-Ferlan PM (1997), Kaabeche K (2004), Wu J (2008), Tanaka S (1995), Marcilla A (1995)	6
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
SH2B2	1	CBL	7	pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wakioka T (1999), Ng C (2008), Hu J (2005), Hu J (2005), Onnockx S (2008), Yokouchi M (1999), Yokouchi M (1999)	7
EPOR	3	CUL2	3	affinity chromatography technology	Heir P (2016)	1
GRB2	2	INPP5D	2	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavanaugh WM (1996), Kavanaugh WM (1996), de Castro RO (2012), Ho JM (2002)	4
EPOR	3	CBL	7	affinity chromatography technology	Wakioka T (1999)	1
INPP5D	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), Wisniewski D (1999), Leitges M (2002), Damen JE (1996), Damen JE (1996), March ME (2000), Hunter MG (2004), Ho JM (2002)	9
EPOR	3	MST1R	4	affinity chromatography technology	van den Akker E (2004)	1
PIK3R1	6	VHL	0	genetic interference	Shen JP (2017)	1
PLCG1	6	IRS2	6	affinity chromatography technology, affinity chromatography technology, unspecified method	Sozzani P (1998), Sozzani P (1998), Liu BA (2012)	3
EPOR	3	GNAI1	10	pull down	Guillard C (2003)	1
VAV1	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Bertagnolo V (1998), Bertagnolo V (1998), Bertagnolo V (1998), Shigematsu H (1997), Shigematsu H (1997), Shigematsu H (1997)	6
CUL2	3	ELOC	0	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kamura T (2001), Maine GN (2007), Megumi Y (2005), Mao X (2009), Lonergan KM (1998), Lonergan KM (1998), Bennett EJ (2010), Pause A (1997), Pause A (1999), Kamura T (2004), Kelsall IR (2013), Lee SB (2016)	12
VAV1	2	EPOR	3	affinity chromatography technology	Shigematsu H (1997)	1
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
SRC	2	PTPN6	0	enzymatic study	Frank C (2004)	1
LYN	2	EPOR	3	pull down, affinity chromatography technology, affinity chromatography technology	Chin H (1998), Chin H (1998), Chin H (1998)	3
CRKL	1	INPP5D	2	pull down, affinity chromatography technology	Arai A (2001), Arai A (2001)	2
SOCS2	1	ELOB	1	affinity chromatography technology, biochemical	Vesterlund M (2011), Kim DY (2013)	2
SYK	3	VAV1	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Deckert M (1996), Deckert M (1996), Deckert M (1996), Song JS (1996), Bertagnolo V (2001), Bertagnolo V (2001), Tartare-Deckert S (2001)	7
SH2B2	1	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Yokouchi M (1997)	2
SYK	3	LYN	2	affinity chromatography technology, pull down	Sidorenko SP (1995), Sidorenko SP (1995)	2
RACK1	2	CUL2	3	affinity chromatography technology	Zhang W (2008)	1
GRB2	2	SYK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Saci A (2002), de Castro RO (2012), de Castro RO (2012)	4
SOCS3	0	VHL	0	affinity chromatography technology	Russell RC (2011)	1
CRKL	1	STAT5A	4	affinity chromatography technology, pull down, affinity chromatography technology	Ota J (1998), Ota J (1998), Oda A (1998)	3
VHL	0	RACK1	2	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	He X (2011), He X (2011), He X (2011), He X (2011)	4
NOSIP	2	PTPN11	20	affinity chromatography technology	Huttlin EL (2017)	1
PTPN6	0	EPOR	3	affinity chromatography technology, pull down	Klingmueller U (1995), Klingmueller U (1995)	2
EPOR	3	INPP5D	2	protein complementation assay	Montoye T (2005)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
EPOR	3	PTPN11	20	affinity chromatography technology, pull down	Tauchi T (1996), Tauchi T (1995)	2
EPOR	3	ELOB	1	pull down	Heir P (2016)	1
SOCS3	0	EPOR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Sasaki A (2000), Sasaki A (2000), Sasaki A (2000), Hoertner M (2002)	4
INPP5D	2	CBL	7	affinity chromatography technology	Bao M (2012)	1
EPOR	3	STAT5A	4	affinity chromatography technology, pull down, protein complementation assay, pull down	Chin H (1996), Chin H (1996), Montoye T (2005), Wakioka T (1999)	4
SHC1	0	SRC	2	pull down	Schueller AC (2008)	1
INPP5D	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu L (1997), Chernock RD (2001), Chernock RD (2001)	3
MST1R	4	PLCG1	6	affinity chromatography technology	Iwama A (1996)	1
VHL	0	JAK2	1	affinity chromatography technology, affinity chromatography technology	Russell RC (2011), Russell RC (2011)	2
EGLN3	0	CBL	7	affinity chromatography technology	Rodriguez J (2016)	1
CBL	7	CRKL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Alsayed Y (2000), Alsayed Y (2000), Kyono WT (1998), Lin H (2001), Park RK (1998), Taher TE (2002), Sattler M (1997), Erdreich-Epstein A (1999), Erdreich-Epstein A (1999), Sattler M (1997), Sattler M (1997), Gesbert F (1998), Chin H (1997), Feshchenko EA (2004), Izadi KD (1998), de Jong R (1995), de Jong R (1995), Boussiotis VA (1997), Boussiotis VA (1997), Barber DL (1997), Uemura N (1999), Okabe S (2006), Alsayed Y (2000), Alsayed Y (2000), Brenner B (2001), van Leeuwen JE (1999), Ribon V (1996), Bhat A (1997), Bhat A (1997), Huang JY (2000), Chernock RD (2001), Chernock RD (2001), Grossmann AH (2004), Sakamoto H (2004), Nishihara T (2003), Peterson ME (2008), Fukazawa T (1996), Martelli MP (2001), Joshi S (2014), Grossmann A (2015)	40
CRKL	1	EPOR	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Chin H (1997), Arai A (2001), Arai A (2001), Barber DL (1997)	4
RACK1	2	EPOR	3	pull down	Usacheva A (2003)	1
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
EPOR	3	EGLN3	0	affinity chromatography technology, pull down	Heir P (2016), Heir P (2016)	2
EPOR	3	PLCG1	6	protein complementation assay	Montoye T (2005)	1
PLCG1	6	SYK	3	affinity chromatography technology	Sidorenko SP (1995)	1
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1