PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TFAP4	3	NR2F2	4	affinity chromatography technology	Ku WC (2009)	1
APLNR	1	NR2F6	1	affinity chromatography technology	Huttlin EL (2017)	1
THRB	1	RXRG	1	two hybrid	Albers M (2005)	1
NR3C1	2	JUN	0	pull down	Lerner L (2003)	1
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
NR2F6	1	BCL11A	14	two hybrid, two hybrid	Chan CM (2013), Chan CM (2013)	2
MPPED2	4	RXRG	1	two hybrid	Rolland T (2014)	1
RARG	2	NR2F6	1	two hybrid	Avram D (1999)	1
TFAP4	3	NR2F6	1	affinity chromatography technology	Ku WC (2009)	1
MPPED2	4	NR2F6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NSD1	25	NR2F2	4	two hybrid	Chan CM (2013)	1
NR2F6	1	NR3C1	2	pull down	Zhu XG (2000)	1
RXRG	1	RXRA	1	affinity chromatography technology	Huttlin EL (2017)	1
ESR1	0	NCOA1	6	pull down, pull down, pull down, pull down, two hybrid, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	DiRenzo J (2000), Sheppard HM (2001), Kalkhoven E (1998), Kang YK (2002), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Tremblay A (2001), Llopis J (2000), Chien PY (1999), Webb P (1998), Webb P (1998), Lazennec G (1997), Heery DM (1997), Heery DM (1997), Torchia J (1997), Torchia J (1997), Fleming FJ (2004), Fujita T (2003), Fujita T (2003), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Gong EY (2010), Eng FC (1998), Needham M (2000), Needham M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Albers M (2005), Kurtev V (2004), DiRenzo J (1997), Han SJ (2016), Han SJ (2016)	37
RARG	2	NCOA1	6	two hybrid, pull down	Albers M (2005), Flajollet S (2007)	2
RXRG	1	NR2F6	1	affinity chromatography technology	Huttlin EL (2017)	1
C5AR2	1	NR2F6	1	affinity chromatography technology	Huttlin EL (2017)	1
FOS	0	ESR1	0	affinity chromatography technology	Baron S (2007)	1
THRB	1	RXRA	1	pull down, pull down, two hybrid, far western blotting, two hybrid, pull down, pull down, pull down, imaging technique	Monden T (1997), Jeyakumar M (1997), Tagami T (2009), Li H (1997), Albers M (2005), White DM (1997), Garcia-Fernandez LF (1998), Liao CS (2009), Liao CS (2009)	9
NR2F6	1	NAP1L1	2	pull down	Miyamoto-Sato E (2010)	1
MOV10	6	NR2F6	1	affinity chromatography technology	Castello A (2012)	1
THRB	1	NCOA1	6	pull down, genetic interference, pull down, unspecified method, two hybrid, two hybrid, pull down, pull down	Liu Y (1998), Jeyakumar M (1997), Jeyakumar M (1997), Jeyakumar M (1997), Albers M (2005), Chan CM (2013), Kim HJ (1999), DiRenzo J (1997)	8
MPPED1	1	NR2F2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NSD1	25	RXRA	1	two hybrid	Chan CM (2013)	1
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
NR3C1	2	NR2F2	4	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	De Martino MU (2004), De Martino MU (2004), De Martino MU (2004), De Martino MU (2004), De Martino MU (2004)	5
RARG	2	RXRA	1	two hybrid	Albers M (2005)	1
JUN	0	NR2F6	1	affinity chromatography technology	Li X (2015)	1
NR3C1	2	NCOA1	6	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Zilliacus J (2001), Kucera T (2002), Windahl SH (1999), Fryer CJ (1998), Needham M (2000), Li G (2006), Lempiaeinen JK (2017)	7
NR2F6	1	ESR1	0	pull down	Zhu XG (2000)	1
JUN	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teyssier C (2001), Baron S (2007), Ruiz ML (2013), Ruiz ML (2013)	4
NSD1	25	THRB	1	two hybrid	Chan CM (2013)	1
NR2F6	1	NCOA1	6	pull down	Zhu XG (2000)	1
RXRA	1	NR2F6	1	two hybrid	Avram D (1999)	1
C5AR2	1	NR2F2	4	affinity chromatography technology	Huttlin EL (2017)	1
NSD1	25	ESR1	0	two hybrid	Chan CM (2013)	1
FOS	0	NR2F6	1	affinity chromatography technology	Li X (2015)	1
NCOA1	6	FOS	0	pull down, two hybrid, pull down, pull down, affinity chromatography technology	Lee SK (2000), Lee SK (1998), Lee SK (1998), Fauquier L (2008), Fauquier L (2008)	5
MPPED1	1	MPPED2	4	affinity chromatography technology	Huttlin EL (2015)	1
BCL11A	14	NR2F2	4	two hybrid, two hybrid, pull down, affinity chromatography technology	Chan CM (2013), Chan CM (2013), Chan CM (2013), Chan CM (2013)	4
NR2F2	4	NR2F6	1	two hybrid, pull down, two hybrid, affinity chromatography technology	Avram D (1999), Avram D (1999), Albers M (2005), Huttlin EL (2017)	4
MPPED1	1	NR2F6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR2F6	1	CBX1	0	pull down	Miyamoto-Sato E (2010)	1
NR2F6	1	THRB	1	pull down, two hybrid, affinity chromatography technology	Zhu XG (2000), Zhu XG (2000), Zhu XG (2000)	3
APLNR	1	NR2F2	4	affinity chromatography technology	Huttlin EL (2017)	1
NSD1	25	NR2F6	1	two hybrid	Chan CM (2013)	1
FOXN1	3	NR2F6	1	affinity chromatography technology	Li X (2015)	1
RARG	2	RXRG	1	two hybrid	Albers M (2005)	1
NCOA1	6	JUN	0	pull down, pull down, two hybrid, pull down	Lee SK (1999), Lee SK (2000), Lee SK (1998), Lee SK (1998)	4