PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBA2	0	SAE1	0	two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Gong L (1999), Desterro JM (1999), Okuma T (1999), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
JUN	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
TRIM25	5	UBA2	0	affinity chromatography technology	Choudhury NR (2017)	1
RFWD2	0	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Bianchi E (2003), Yi C (2005), Lu G (2014), Li X (2015), Huttlin EL (2017), Zou S (2016)	7
TP63	0	STK11	2	affinity chromatography technology	Ratovitski EA (2010)	1
SMAD2	5	ETV4	3	two hybrid, affinity chromatography technology	Huang WY (2011), Huang WY (2011)	2
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
TP63	0	ETV4	3	affinity chromatography technology	Ratovitski EA (2010)	1
SAE1	0	APP	1	pull down	Olah J (2011)	1
RFWD2	0	ETV4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baert JL (2010), Vitari AC (2011), Lu G (2014)	3
TP63	0	CARM1	0	affinity chromatography technology	Amoresano A (2010)	1
ATXN1	2	ETV4	3	two hybrid	Suter B (2013)	1
ETV4	3	CARM1	0	affinity chromatography technology	Huttlin EL (2017)	1
ETV4	3	STK11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Ratovitski EA (2010), Upadhyay S (2006), Upadhyay S (2006), Upadhyay S (2006), Upadhyay S (2006)	5
ETV4	3	HOXD4	2	two hybrid	Ravasi T (2010)	1
UBA2	0	ETV4	3	enzymatic study	Guo B (2009)	1
ETV4	3	APP	1	pull down	Olah J (2011)	1
STK11	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
STK11	2	APP	1	pull down	Olah J (2011)	1
TRIM25	5	ETV4	3	affinity chromatography technology	Choudhury NR (2017)	1
ETV4	3	JUN	0	two hybrid	Matsui K (2006)	1
SAE1	0	ETV4	3	enzymatic study	Guo B (2009)	1
HTT	14	ETV4	3	two hybrid	Suter B (2013)	1
SMAD2	5	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Miyamoto-Sato E (2010)	2
TRIM25	5	RFWD2	0	affinity chromatography technology	Choudhury NR (2017)	1