PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX2	4	NCOR1	9	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
ETV6	1	ACTA1	1	imaging technique	Hannemann JR (1998)	1
VPS26B	0	ETV6	1	affinity chromatography technology	Hein MY (2015)	1
SKP1	0	FBXL6	5	two hybrid, biochemical, affinity chromatography technology	Lievens S (2009), Wan C (2015), Hauri S (2016)	3
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
HDAC6	0	ETV6	1	affinity chromatography technology	Joshi P (2013)	1
NCOR1	9	UBE2I	0	pull down, affinity chromatography technology	Tiefenbach J (2006), Tiefenbach J (2006)	2
HDAC9	7	HDAC3	5	pull down, affinity chromatography technology	Petrie K (2003), Zhou X (2000)	2
KAT5	1	ETV6	1	two hybrid, pull down, affinity chromatography technology	Nordentoft I (2003), Nordentoft I (2003), Nordentoft I (2003)	3
ETV6	1	SIN3A	13	affinity chromatography technology	Wang L (2001)	1
PIN1	0	NFATC2	1	pull down	Liu W (2001)	1
EGLN3	0	HDAC3	5	affinity chromatography technology	Rodriguez J (2016)	1
NCOR1	9	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Farhana L (2007)	2
PDGFRB	8	ETV6	1	affinity chromatography technology	Huang W (2012)	1
ELAVL1	0	ETV6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	CRKL	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ETV6	1	SUMO1	0	two hybrid	Chakrabarti SR (2000)	1
ETV6	1	GAB2	3	affinity chromatography technology	Million RP (2004)	1
KAT5	1	HDAC3	5	affinity chromatography technology	Yi J (2014)	1
NCOR1	9	ETV6	1	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Wang L (2001), Guidez F (2000), Guidez F (2000), Guidez F (2000)	4
SOX2	4	USP7	14	affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Cox JL (2013)	2
SOCS1	1	ETV6	1	affinity chromatography technology, affinity chromatography technology	Monni R (2001), Monni R (2001)	2
KAT5	1	ACTA1	1	affinity chromatography technology	Doyon Y (2004)	1
ETV6	1	GRB2	2	affinity chromatography technology, far western blotting	Million RP (2004), Million RP (2004)	2
USP7	14	ETV6	1	affinity chromatography technology	Hein MY (2015)	1
PDGFRB	8	IRF8	4	affinity chromatography technology	Huang W (2012)	1
NFATC2	1	ETV6	1	affinity chromatography technology	Gabriel CH (2016)	1
KAT5	1	SUMO1	0	affinity chromatography technology	Cheng Z (2008)	1
PIN1	0	ETV6	1	pull down	Ingham RJ (2005)	1
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
EGLN3	0	CRKL	1	affinity chromatography technology	Rodriguez J (2016)	1
SOX2	4	SIN3A	13	affinity chromatography technology	Engelen E (2011)	1
SKP1	0	ETV6	1	affinity chromatography technology	Roukens MG (2008)	1
EGLN3	0	SKP1	0	affinity chromatography technology	Rodriguez J (2016)	1
ETV6	1	CRKL	1	affinity chromatography technology	Million RP (2004)	1
SOCS3	0	ETV6	1	affinity chromatography technology	Monni R (2001)	1
SOCS3	0	PIN1	0	two hybrid	Stelzl U (2005)	1
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
HDAC3	5	PIN1	0	affinity chromatography technology	Rajendran P (2011)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SIN3A	13	HDAC9	7	affinity chromatography technology, pull down	Koipally J (2002), Petrie K (2003)	2
ETV6	1	LRP5	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC9	7	NCOR1	9	pull down, affinity chromatography technology	Petrie K (2003), Petrie K (2003)	2
HDAC6	0	KAT5	1	affinity chromatography technology	Chen PB (2013)	1
TRAF3	1	ETV6	1	affinity chromatography technology	van Zuylen WJ (2012)	1
SOX2	4	SUMO1	0	two hybrid	Rolland T (2014)	1
IRF8	4	ETV6	1	affinity chromatography technology	Kong HJ (2007)	1
FLI1	2	UBE2I	0	two hybrid	van den Akker E (2005)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
ETV6	1	ETV6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hannemann JR (1998), Kwiatkowski BA (1998), Wood LD (2003)	3
ETV6	1	NID2	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GAB2	3	CRKL	1	affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology	Crouin C (2001), Crouin C (2001), Crouin C (2001), Schaeper U (2000)	4
SOX2	4	ETV6	1	affinity chromatography technology	Cox JL (2013)	1
ETV6	1	UBE2I	0	two hybrid, pull down	Chakrabarti SR (1999), Chakrabarti SR (1999)	2
ETV6	1	FLI1	2	two hybrid, pull down, affinity chromatography technology	Kwiatkowski BA (1998), Kwiatkowski BA (1998), Kwiatkowski BA (1998)	3
EGLN3	0	ETV6	1	affinity chromatography technology	Rodriguez J (2016)	1
UBE2I	0	TRAF3	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Miliara S (2013), Miliara S (2013), Miliara S (2013), Miliara S (2013)	4
ETV6	1	AP1M1	3	two hybrid	Rolland T (2014)	1
CRKL	1	SOCS1	1	two hybrid	Grossmann A (2015)	1
ETV6	1	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Wang L (2001), Wang L (2001)	2
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
KAT5	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheng Z (2008), Cheng Z (2008), Cheng Z (2008)	3
SOX2	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
EGLN3	0	NCOR1	9	affinity chromatography technology	Rodriguez J (2016)	1
ETV6	1	WDYHV1	0	two hybrid	Rolland T (2014)	1
GRB2	2	GAB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2004), Lynch DK (2002), Zhao C (1999), Zhao C (1999), Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Rolland T (2014), Huttlin EL (2017), Yu WM (2006), Yu WM (2006)	11
FBXL6	5	ETV6	1	affinity chromatography technology, affinity chromatography technology, pull down	Roukens MG (2008), Roukens MG (2008), Roukens MG (2008)	3
HDAC9	7	ETV6	1	affinity chromatography technology	Petrie K (2003)	1
L3MBTL1	1	ETV7	2	affinity chromatography technology	Boccuni P (2003)	1
ETV7	2	ETV6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
HDAC6	0	USP7	14	affinity chromatography technology	Joshi P (2013)	1
USP7	14	CRKL	1	affinity chromatography technology	Sowa ME (2009)	1
USP7	14	TRAF3	1	pull down	Zapata JM (2001)	1
KAT5	1	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Du Z (2010), Dar A (2013), Dar A (2013), Dar A (2013), Cui H (2015)	5
ETV6	1	L3MBTL1	1	affinity chromatography technology, pull down	Boccuni P (2003), Boccuni P (2003)	2
ETV6	1	LRP6	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	PDGFRB	8	pull down, pull down, affinity chromatography technology	Arvidsson AK (1994), Tang J (1997), Braverman LE (1999)	3
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
ELAVL1	0	SOCS3	0	affinity chromatography technology	Do KH (2013)	1
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1