PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
F2	2	ST13	2	enzymatic study	Velten M (2002)	1
FN1	17	CPB2	0	affinity chromatography technology	Moussavi-Harami SF (2013)	1
ALB	1	SERPING1	2	affinity chromatography technology	Zhou M (2004)	1
SERPINB6	0	PLAT	2	affinity chromatography technology	Huttlin EL (2017)	1
FN1	17	F2	2	affinity chromatography technology	Moussavi-Harami SF (2013)	1
ALB	1	FN1	17	affinity chromatography technology	Zhou M (2004)	1
ITGA2B	2	F2	2	pull down	Plow EF (2001)	1
SERPINB6	0	F2	2	pull down	Coughlin P (1993)	1
F2	2	FGA	5	x-ray crystallography, imaging technique	Stubbs MT (1992), Chen TC (2014)	2
FN1	17	ST13	2	affinity chromatography technology	Humphries JD (2009)	1
ITGA2B	2	FN1	17	pull down	Kauf AC (2001)	1
THBS1	6	FGA	5	pull down	Panetti TS (1999)	1
F2	2	SERPIND1	5	x-ray crystallography	Baglin TP (2002)	1
F2	2	SERPINE1	0	pull down	Dekker RJ (2003)	1
ALB	1	F2	2	affinity chromatography technology	Zhou M (2004)	1
FN1	17	PLAT	2	pull down	Moser TL (1993)	1
PLAT	2	F2	2	x-ray crystallography	Dekker RJ (1999)	1
SERPING1	2	PLAT	2	affinity chromatography technology	Huttlin EL (2017)	1
DDIT3	1	F2	2	two hybrid	Wang J (2011)	1
FGA	5	PLAT	2	pull down, pull down	Tsurupa G (2001), Ichinose A (1986)	2
SERPINE1	0	PLAT	2	pull down	Madison EL (1990)	1
ALB	1	ST13	2	affinity chromatography technology	Zhou M (2004)	1
F2	2	F5	5	pull down	Deguchi H (1997)	1
THBS1	6	F2	2	pull down	Asch AS (1987)	1
ALB	1	FGA	5	affinity chromatography technology	Zhou M (2004)	1
SPP1	0	F2	2	imaging technique	Chen TC (2014)	1
F2	2	CPB2	0	pull down	Bajzar L (1996)	1
F2	2	THBD	0	pull down, pull down	Bajzar L (1996), Jakubowski HV (1989)	2
F2	2	SERPING1	2	pull down	Cugno M (2001)	1
FN1	17	FGA	5	affinity chromatography technology	Moussavi-Harami SF (2013)	1
FGA	5	ITGA2B	2	unspecified method	Wierzbicka I (1997)	1