PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAB2	5	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Li S (2011), Li S (2011), Mendoza H (2008), Shin MS (2009), Suzuki S (2007), Jiang Z (2002), Wang J (2011), Xia ZP (2009), Charlaftis N (2014), St-Denis N (2016)	14
F2R	1	PROCR	0	affinity chromatography technology, affinity chromatography technology	Bae JS (2010), Bae JS (2010)	2
CAV1	0	PROCR	0	affinity chromatography technology, affinity chromatography technology	Bae JS (2010), Bae JS (2010)	2
MAPK14	0	TAB2	5	affinity chromatography technology	Grimsey NJ (2015)	1
F2R	1	ARRDC3	0	fluorescent resonance energy transfe	Dores MR (2015)	1
MMP1	0	F2R	1	imaging technique	Chen TC (2014)	1
F2R	1	CAV1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Banfi C (2007), Banfi C (2007), Banfi C (2007), Bae JS (2010), Bae JS (2010)	5
F2R	1	FLOT2	1	affinity chromatography technology	Hazarika P (2004)	1
SNX1	2	F2R	1	pull down, affinity chromatography technology	Wang Y (2002), Wang Y (2002)	2
ATP13A2	1	F2R	1	two hybrid	Usenovic M (2012)	1
CAPN1	3	F2R	1	imaging technique	Chen TC (2014)	1
PDCD6IP	3	CHMP4A	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rauch S (2011), von Schwedler UK (2003), Strack B (2003), Strack B (2003), Carlton JG (2008)	5
F2R	1	GNAI2	1	affinity chromatography technology	Ogino Y (1996)	1
CRYL1	0	F2R	1	affinity chromatography technology	Huttlin EL (2017)	1
GNA13	0	F2R	1	affinity chromatography technology, affinity chromatography technology	Offermanns S (1994), El-Haibi CP (2013)	2
TAB1	1	MAPK14	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Ge B (2002), Ge B (2002), Vinayagam A (2011), Ge B (2003), Chen TC (2014), Grimsey NJ (2015)	6
F2R	1	PDCD6IP	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Dores MR (2012), Dores MR (2012), Dores MR (2012), Dores MR (2015)	4
GNA12	2	F2R	1	affinity chromatography technology	Offermanns S (1994)	1
CHRD	5	F2R	1	two hybrid	Wang J (2011)	1
CAV1	0	FLOT2	1	affinity chromatography technology	Volonte D (1999)	1
PDCD6IP	3	ARRDC3	0	two hybrid	Rauch S (2011)	1
F2R	1	TAB2	5	affinity chromatography technology	Grimsey NJ (2015)	1
F2R	1	AP3D1	7	affinity chromatography technology	Dores MR (2012)	1
TAB1	1	PDCD6IP	3	two hybrid	Vinayagam A (2011)	1
F2R	1	TAB1	1	affinity chromatography technology	Grimsey NJ (2015)	1
F2R	1	CHMP4A	1	affinity chromatography technology	Dores MR (2012)	1
F2R	1	MAPK14	0	affinity chromatography technology	Grimsey NJ (2015)	1
GRPR	0	F2R	1	affinity chromatography technology	Huttlin EL (2017)	1
F2R	1	GNAQ	1	affinity chromatography technology	Ogino Y (1996)	1