Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ALDH2	217	PRUNETIN	CHEMBL491174	inhibitor	GuideToPharmacologyInteractions
ALDH2	217	CROTONALDEHYDE	CHEMBL1086445		DrugBank	17139284, 17016423
ALDH2	217	DAIDZIN	CHEMBL486422		DrugBank	17139284, 17016423, 10592235
ALDH2	217	ALCOHOL	CHEMBL545		NCI	8986223
ALDH2	217	CHEMBL1161866	CHEMBL1161866		DrugBank	16961761, 17488809
ALDH2	217	DISULFIRAM	CHEMBL964	inhibitor	TdgClinicalTrial, ChemblInteractions, TEND, DrugBank	17220694, 16051882

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ALDH2	rs671	AA + AG	nitroglycerin	efficacy	yes	Patients without ALDH2*2 variant had greater reduction in pulmonary vascular resistance (PVR) than patients with the variant (delta1.1±0.6 Wood units·m2 vs. delta0.6±0.2 Wood units·m2, p<0.05). The haemodynamic effects of the drug were lower in patients with the ALDH2 gene polymorphisms.	Genotypes AA + AG is associated with decreased response to nitroglycerin in children with Heart Defects, Congenital as compared to genotype GG.	31250045	1451094520
ALDH2	rs671	AA + AG	nitroglycerin	metabolism/PK	yes	"GTN treatment started at a dose of 2 μg/kg/min, and the dose was escalated by 1-2 μg/kg/min until pulmonary vascular resistance (PVR) was reduced by more than 30%," suggesting those with the *2 variant required higher doses and had higher plasma drug concentration.	Genotypes AA + AG are associated with increased concentrations of nitroglycerin in children with Heart Defects, Congenital and Hypertension, Pulmonary as compared to genotype GG.	31250045	1451094560
ALDH2	rs671	AG	ethanol	other	yes	Healthy men with the ALDH2*1/*2 genotype had significantly higher blood ethanol levels (p,0.05), higher blood–acetaldehyde concentrations (p<0.001), significantly higher increase in pulse rate (p<0.001) and an earlier facial skin blood flow (FSBF) (p<0.001) compared to *1/*1 after one time ingesting 0.3¿g/kg of alcohol.	Genotype AG is associated with increased exposure to ethanol in men as compared to genotype GG.	25365528	1450971980
ALDH2	rs671	AG	ethanol	metabolism/PK	yes	Blood alcohol concentration (BAC) was significantly higher in AG individuals compared to GG from 15 minutes to 300 minutes after alcohol dosing. Note that individuals with the AA genotype were excluded from the study.	Genotype AG is associated with increased concentrations of ethanol in healthy individuals as compared to genotype GG.	31002879	1450936677
ALDH2	rs671	AG	acetaldehyde	metabolism/PK	yes	Blood concentrations of acetaldehyde, a metabolite of ethanol, were significantly higher in AG individuals compared to GG from 15 minutes to 300 minutes after alcohol dosing. Note that individuals with the AA genotype were excluded from the study.	Genotype AG is associated with increased concentrations of acetaldehyde in healthy individuals as compared to genotype GG.	31002879	1450936718