PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	RASA1	3	pull down, unspecified method, pull down	Daly RJ (1996), Jones RB (2006), Marengere LE (1992)	3
FYN	1	SYK	3	affinity chromatography technology, pull down	Deckert M (1998), Deckert M (1998)	2
ERBB2	6	JAK2	1	affinity chromatography technology	Ren Z (2002)	1
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
PTPN12	2	PTK2B	6	enzymatic study	Lyons PD (2001)	1
JAK2	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Olayioye MA (1999), Olayioye MA (1999), Jones RB (2006), He K (2013)	4
FYN	1	SKAP2	1	affinity chromatography technology, enzymatic study	Kouroku Y (1998), Takahashi T (2003)	2
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
PTEN	24	PXN	1	affinity chromatography technology	Haier J (2002)	1
CBLB	3	VAV1	2	affinity chromatography technology, two hybrid, pull down, far western blotting, affinity chromatography technology	Sattler M (2002), Bustelo XR (1997), Bustelo XR (1997), Bustelo XR (1997), Bustelo XR (1997)	5
LCK	0	SYK	3	affinity chromatography technology, pull down, two hybrid	Thome M (1995), Thome M (1995), Moon KD (2005)	3
PTK2B	6	BCAR1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Manie SN (1997), Anfosso F (2001), Astier A (1997), Takahashi T (2003)	4
NEDD9	3	BCAR1	6	affinity chromatography technology	Law SF (1999)	1
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
ERBB2	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Vogel W (1996)	5
PTK2B	6	PITPNM3	5	two hybrid, pull down, affinity chromatography technology	Lev S (1999), Lev S (1999), Lev S (1999)	3
HSP90AA1	7	PTK2B	6	affinity chromatography technology	Taipale M (2012)	1
PXN	1	PTK2B	6	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hiregowdara D (1997), Hiregowdara D (1997), Matsuya M (1998), Matsuya M (1998), Anfosso F (2001), Ivankovic-Dikic I (2000)	6
SRC	2	BCAR1	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Burnham MR (1999), Burnham MR (1999), Wei L (2002), Hsia DA (2003), Kovacic-Milivojevic B (2001), Donaldson JC (2000), Angers-Loustau A (1999), Cabodi S (2004), Modzelewska K (2006), Sawada Y (2006), Riggins RB (2006), Riggins RB (2006)	12
SORBS2	2	CBL	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Soubeyran P (2003), Soubeyran P (2003), Soubeyran P (2003), Soubeyran P (2003)	6
PTPN6	0	PRKCD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Yoshida K (2001), Yoshida K (2001), Yoshida K (2001), Yoshida K (2001)	4
NEDD4L	3	PTK2B	6	affinity chromatography technology	Verma N (2017)	1
ERBB3	3	PTEN	24	two hybrid	Yao Z (2017)	1
PXN	1	NEDD9	3	affinity chromatography technology	Zhang Z (1999)	1
PTK2B	6	FYN	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ganju RK (1997), Katagiri T (2000), Qian D (1997), Qian D (1997), Marie-Cardine A (1999)	5
GP6	0	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
LYN	2	PTPN6	0	pull down	Yoshida K (1999)	1
SOCS2	1	PTK2B	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Lee SH (2010), Lee SH (2010), Lee SH (2010)	3
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
PTPN11	20	SOCS3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lehmann U (2003), Lehmann U (2003), Schmitz J (2000), Orr SJ (2007)	4
BCAR1	6	PTPN12	2	affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, bioid	Lin Y (2003), Garton AJ (1997), Garton AJ (1997), Garton AJ (1997), Cote JF (1998), Cote JF (1998), Garton AJ (1996), Garton AJ (1996), St-Denis N (2016)	9
JAK2	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sasaki A (2000), Sasaki A (2000), Sasaki A (1999), Sasaki A (1999), Sasaki A (1999), Masuhara M (1997), Masuhara M (1997), Monni R (2001), Haan S (2009), Babon JJ (2012), Calegari VC (2005), Calegari VC (2005), Varghese LN (2014), Kershaw NJ (2014)	14
HSP90AA1	7	LYN	2	affinity chromatography technology	Taipale M (2012)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
EGFR	5	PTPN6	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Tomic S (1995), Keilhack H (1998), Keilhack H (1998), Yao Z (2017)	4
GP1BB	1	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
PXN	1	ITGB3	6	pull down	Pfaff M (2001)	1
SYK	3	ITGB2	4	affinity chromatography technology	Miura Y (2000)	1
GRIN2A	13	DLG3	1	two hybrid, affinity chromatography technology, pull down	Irie M (1997), Lim IA (2002), Lim IA (2002)	3
PXN	1	FYN	1	affinity chromatography technology	Chen LM (2000)	1
SH3KBP1	1	BCAR1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Tibaldi EV (2003)	3
ERBB2	6	SYK	3	unspecified method	Jones RB (2006)	1
PTK2B	6	PDCD6IP	3	affinity chromatography technology	Schmidt MH (2003)	1
PTEN	24	EGFR	5	affinity chromatography technology	Zheng J (2016)	1
PTK2B	6	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Sanjay A (2001), Schmidt MH (2003)	4
GP6	0	LYN	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki-Inoue K (2002), Suzuki-Inoue K (2002), Locke D (2003), Arthur JF (2011)	4
CBLB	3	TGFB1I1	2	two hybrid	Ryan PE (2012)	1
NEDD9	3	FYN	1	affinity chromatography technology	Tachibana K (1997)	1
PTPN12	2	PXN	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, bioid, affinity chromatography technology	Shen Y (2000), Shen Y (2000), Shen Y (2000), Cote JF (1999), Cote JF (1999), Shen Y (1998), Shen Y (1998), St-Denis N (2016), Huttlin EL (2017)	9
JAK1	6	SOCS3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Park ES (2000), Cohney SJ (1999), Cohney SJ (1999), Cohney SJ (1999)	4
GSN	3	PXN	1	affinity chromatography technology	Chellaiah MA (2001)	1
ERBB3	3	PTK2B	6	affinity chromatography technology	Verma N (2017)	1
JAK2	1	SLC2A1	5	affinity chromatography technology	So J (2015)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
FYN	1	MAPT	1	affinity chromatography technology, pull down, pull down, enzymatic study	Klein C (2002), Klein C (2002), Bhaskar K (2005), Bhaskar K (2005)	4
PTK2B	6	MBD2	1	two hybrid, pull down, affinity chromatography technology	Luo SW (2009), Luo SW (2009), Luo SW (2009)	3
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
SRC	2	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schmidt MH (2005), Schmidt MH (2005), Zhou X (2010), Zhou X (2010)	4
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
CBLB	3	LCK	0	affinity chromatography technology	Kumar S (2011)	1
ERBB3	3	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Verma N (2017), Verma N (2017)	2
PTK2B	6	PITPNM2	4	two hybrid, affinity chromatography technology	Lev S (1999), Lev S (1999)	2
NEDD4	2	PTK2B	6	affinity chromatography technology	Verma N (2017)	1
DNM1	21	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Bruzzaniti A (2009), Bruzzaniti A (2009)	2
GRB2	2	BCAR1	6	affinity chromatography technology, pull down, affinity chromatography technology	Wang X (2000), Angers-Loustau A (1999), Ambrogio C (2005)	3
SYK	3	MAPT	1	enzymatic study, affinity chromatography technology	Lebouvier T (2008), Lebouvier T (2008)	2
SH3KBP1	1	DNM1	21	affinity chromatography technology	Havrylov S (2009)	1
CBLB	3	PTPN11	20	affinity chromatography technology	Hoff H (2007)	1
PTK2B	6	GRB2	2	affinity chromatography technology, affinity chromatography technology	Blaukat A (1999), Bruzzaniti A (2009)	2
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
PTK2B	6	RASA1	3	affinity chromatography technology, pull down, affinity chromatography technology	Chow A (2000), Chow A (2000), Zrihan-Licht S (2000)	3
VAV1	2	PTPN6	0	pull down	Kon-Kozlowski M (1996)	1
PDCD6IP	3	ALG2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007), Okumura M (2009), Okumura M (2009), Katoh K (2005), Katoh K (2005), Inuzuka T (2010), Shibata H (2008)	8
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
EGFR	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soubeyran P (2002), Szymkiewicz I (2002), Schmidt MH (2004), Schmidt MH (2003), Ronning SB (2011), Ronning SB (2011), Yang S (2006), Schmidt MH (2003)	8
RASA1	3	PXN	1	affinity chromatography technology	Shikata Y (1999)	1
PTPN6	0	PTPN12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Li X (2016)	2
BCAR1	6	PTPN11	20	affinity chromatography technology	Manie SN (1997)	1
GRB2	2	GIT1	10	two hybrid, affinity chromatography technology	Vinayagam A (2011), Bisson N (2011)	2
JAK3	3	SOCS3	0	affinity chromatography technology	Cho-Vega JH (2004)	1
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
LCK	0	SOCS2	1	affinity chromatography technology	Venkitachalam S (2011)	1
GSN	3	PTPN12	2	affinity chromatography technology	Chellaiah MA (2001)	1
EGFR	5	SORBS2	2	protein complementation assay	Deribe YL (2009)	1
GP1BB	1	TRAF4	1	pull down, affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011), Arthur JF (2011)	3
CBLB	3	PTK2B	6	affinity chromatography technology	Fan Y (2014)	1
SRC	2	PTK2B	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Keely SJ (2000), Kumar S (1999), Dikic I (1996), Dikic I (1996), Bruzzaniti A (2009)	5
SLC2A1	5	PTK2B	6	affinity chromatography technology	Bandyopadhyay G (2000)	1
LYN	2	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
PTK2B	6	KCNA2	6	affinity chromatography technology	Byron KL (2002)	1
SH3KBP1	1	CBLB	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Szymkiewicz I (2002), Szymkiewicz I (2002), Szymkiewicz I (2002), Havrylov S (2009), Moncalian G (2006), Jozic D (2005), Jozic D (2005), Kowanetz K (2003), Ceregido MA (2013), Ceregido MA (2013), Ceregido MA (2013)	11
PTK2B	6	ALG2	2	affinity chromatography technology	Schmidt MH (2003)	1
NEDD4	2	GRIN2A	13	pull down	Gautam V (2013)	1
ALG2	2	HSP90AA1	7	biochemical	Katoh K (2005)	1
SRC	2	GRIN2A	13	affinity chromatography technology, pull down, affinity chromatography technology	Ma J (2003), Takagi N (1999), Takagi N (1999)	3
GRB2	2	PDCD6IP	3	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
VAV1	2	EGFR	5	affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Moores SL (2000), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	4
LYN	2	JAK2	1	pull down	Chin H (1998)	1
CBL	7	PXN	1	affinity chromatography technology, affinity chromatography technology	Rafiq K (2011), Salgia R (1996)	2
FYN	1	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Tang H (1999), Chernock RD (2001)	2
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
BCAR1	6	NPHP1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Donaldson JC (2000), Donaldson JC (2000), Benzing T (2001), Eley L (2008), Eley L (2008), Eley L (2008)	6
PTK2B	6	ITGB3	6	pull down	Pfaff M (2001)	1
ERBB2	6	PTPN6	0	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
SRC	2	JAK2	1	affinity chromatography technology	Liang K (2010)	1
PTK2B	6	GSN	3	two hybrid, affinity chromatography technology, enzymatic study	Wang Q (2003), Wang Q (2003), Wang Q (2003)	3
PRKCD	2	GNA13	0	enzymatic study	Offermanns S (1996)	1
EGFR	5	EWSR1	2	affinity chromatography technology	Tong J (2014)	1
EGFR	5	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Keely SJ (2000), Ivankovic-Dikic I (2000)	2
NEDD9	3	LYN	2	pull down, affinity chromatography technology	Manie SN (1997), Manie SN (1997)	2
TRAF4	1	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
ERBB3	3	SYK	3	unspecified method	Jones RB (2006)	1
PTK2B	6	JAK3	3	affinity chromatography technology	Miyazaki T (1998)	1
CBL	7	PTPN6	0	affinity chromatography technology	Kant AM (2002)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
EGFR	5	TLN1	5	unspecified method	Jones RB (2006)	1
JAK2	1	PTK2B	6	affinity chromatography technology	Frank GD (2002)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
NEDD4	2	PTEN	24	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wang X (2008), Wang X (2008), Yim EK (2009), Chung S (2011), Wu Y (2013), Hong SW (2013), Hong SW (2013), Li N (2015), Li Z (2014), Chen Z (2016), Ahn Y (2008)	11
LCK	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012)	2
GRIN2A	13	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology	Hou XY (2002), Hou XY (2002), Irie M (1997), Irie M (1997), Satoh K (1997), Sans N (2000), Lim IA (2002), Lim IA (2002), Niethammer M (1996), Niethammer M (1996), Papadakis M (2004)	11
ERBB3	3	PTPN11	20	affinity chromatography technology, two hybrid	Crovello CS (1998), Yao Z (2017)	2
LCK	0	PTK2B	6	affinity chromatography technology	Ganju RK (1997)	1
IL7R	2	FYN	1	affinity chromatography technology	Seckinger P (1994)	1
DLG4	11	PTK2B	6	affinity chromatography technology, pull down	Seabold GK (2003), Seabold GK (2003)	2
SYK	3	PTK2B	6	affinity chromatography technology	Ganju RK (2000)	1
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
JAK2	1	VAV1	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Matsuguchi T (1995)	3
PTK2B	6	TLN1	5	affinity chromatography technology	Zheng C (1998)	1
NEDD4	2	CBLB	3	pull down, affinity chromatography technology, affinity chromatography technology	Magnifico A (2003), Magnifico A (2003), Magnifico A (2003)	3
NPHP1	2	CBL	7	bioid	Gupta GD (2015)	1
PTK2B	6	NEDD9	3	affinity chromatography technology	Manie SN (1997)	1
ERBB2	6	VAV1	2	unspecified method	Jones RB (2006)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
EGFR	5	ITGB2	4	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
JAK2	1	ERBB3	3	unspecified method	Jones RB (2006)	1
SORBS2	2	PTK2B	6	affinity chromatography technology, pull down	Haglund K (2004), Haglund K (2004)	2
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
PTPN6	0	PTK2B	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ganju RK (2000), Ganju RK (2000), Kumar S (1999), Kumar S (1999), Kumar S (1999)	5
CBL	7	TRAF4	1	two hybrid	Woodsmith J (2012)	1
CBL	7	IL7R	2	affinity chromatography technology	Rathinam C (2010)	1
EWSR1	2	MAPT	1	bioid	Elzi DJ (2014)	1
SOCS3	0	SOCS2	1	affinity chromatography technology	Tannahill GM (2005)	1
SORBS2	2	PTPN12	2	affinity chromatography technology, pull down, affinity chromatography technology	Taieb D (2008), Taieb D (2008), Taieb D (2008)	3
BCAR1	6	LCK	0	pull down	Manie SN (1997)	1
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
PRKCD	2	PTK2B	6	affinity chromatography technology	Wrenn RW (2001)	1
FYN	1	CBLB	3	two hybrid	Grossmann A (2015)	1
CBL	7	ERBB2	6	pull down, affinity chromatography technology	Zhou P (2003), Bisaro B (2016)	2
GIT1	10	PXN	1	affinity chromatography technology	Ko J (2003)	1
EGFR	5	SOCS3	0	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Xia L (2002), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
ITGB3	6	SYK	3	affinity chromatography technology	Saci A (2000)	1
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
GP6	0	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
EGFR	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study	Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996)	7
FYN	1	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015)	27
ASAP2	5	SH3KBP1	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
DLG3	1	PTK2B	6	affinity chromatography technology, affinity chromatography technology, pull down	Seabold GK (2003), Seabold GK (2003), Seabold GK (2003)	3
CBL	7	VAV1	2	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Bertagnolo V (2001), Miura-Shimura Y (2003), Simmons A (2005), Shen M (2009), Shen M (2009), Lottin-Divoux S (2006), Lottin-Divoux S (2006), Peterson ME (2008)	12
TLN1	5	ITGB3	6	pull down, pull down, pull down, pull down, pull down	Patil S (1999), Calderwood DA (2002), Calderwood DA (2002), Anthis NJ (2009), Ulmer TS (2001)	5
LYN	2	BCAR1	6	affinity chromatography technology, affinity chromatography technology	Manie SN (1997), Qiu W (1998)	2
CBLB	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ettenberg SA (1999), Lavagna-Sevenier C (1998), Lavagna-Sevenier C (1998), Elly C (1999), Bandyopadhyay S (2010), Vinayagam A (2011), Bisson N (2011), Blagoev B (2003), Rolland T (2014), Huttlin EL (2017)	10
BCAR1	6	FYN	1	two hybrid, affinity chromatography technology, pull down	Donaldson JC (2000), Manie SN (1997), Manie SN (1997)	3
CBL	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
GP1BB	1	LYN	2	affinity chromatography technology	Arthur JF (2011)	1
PTPN11	20	PTK2B	6	affinity chromatography technology, affinity chromatography technology, far western blotting, enzymatic study	Chauhan D (2000), Chauhan D (2000), Chauhan D (2000), Chauhan D (2000)	4
PTK2B	6	SH3KBP1	1	affinity chromatography technology	Schmidt MH (2003)	1
SYK	3	PXN	1	affinity chromatography technology	Fernandez R (1998)	1
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
SRC	2	PTPN11	20	enzymatic study	Vogel W (1996)	1
CBL	7	SYK	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Lupher ML (1998), Lupher ML (1998), Bertagnolo V (2001), Melander F (2003), Macglashan D (2004), Rao N (2001), Rao N (2001), Yankee TM (1999), Saci A (2000), Moon KD (2005), Lottin-Divoux S (2006), Grossmann AH (2004), Ota S (2000), Ota S (2000), Panchamoorthy G (1996), Marcilla A (1995), Justa-Schuch D (2016)	17
GRB2	2	DNM1	21	pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Miki H (1994), Miki H (1994), Sastry L (1997), Solomaha E (2005), Brehme M (2009), Bisson N (2011), Stamenova SD (2007), Huttlin EL (2017)	8
GRIN2A	13	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Seabold GK (2003), Liu Y (2001)	2
FYN	1	KCNA2	6	affinity chromatography technology	Nitabach MN (2001)	1
NEDD4	2	SYK	3	pull down	Persaud A (2009)	1
JAK2	1	HSP90AA1	7	affinity chromatography technology	Cheng MB (2010)	1
LPXN	4	PTK2B	6	affinity chromatography technology	Lipsky BP (1998)	1
PRKCD	2	HSP90AA1	7	pull down	Rex EB (2010)	1
LCK	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
TGFB1I1	2	PTK2B	6	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Matsuya M (1998), Wang X (2002), Wang X (2002), Wang X (2002), Wang X (2002), Matsuya M (1998), Matsuya M (1998), Thomas SM (1999)	8
LYN	2	SKAP2	1	affinity chromatography technology	Kouroku Y (1998)	1
PTPN6	0	SYK	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ganju RK (2000), Dustin LB (1999), Dustin LB (1999)	3
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
PTK2B	6	LYN	2	affinity chromatography technology	Yamasaki M (2001)	1
SRC	2	PXN	1	pull down	Angers-Loustau A (1999)	1
GRB2	2	PXN	1	pull down	Angers-Loustau A (1999)	1
NEDD4	2	SRC	2	affinity chromatography technology, pull down, enzymatic study	Persaud A (2014), Persaud A (2014), Persaud A (2014)	3
DNM1	21	SRC	2	pull down, affinity chromatography technology	Solomaha E (2005), Bruzzaniti A (2009)	2
JAK2	1	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Jiao H (1996), Wu DW (2000)	2
PTK2B	6	ERBB2	6	affinity chromatography technology, imaging technique	Zrihan-Licht S (2000), Chen TC (2014)	2
ERBB3	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Li J (2013)	3
ERBB3	3	PTPN12	2	two hybrid	Yao Z (2017)	1
LYN	2	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Taher TE (2002), Dombrosky-Ferlan PM (1997), Kaabeche K (2004), Wu J (2008), Tanaka S (1995), Marcilla A (1995)	6
RASA1	3	SRC	2	affinity chromatography technology, enzymatic study	Brott BK (1991), Giglione C (2001)	2
BCAR1	6	ERBB2	6	affinity chromatography technology	Bisaro B (2016)	1
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
JAK3	3	JAK1	6	affinity chromatography technology	Doucet C (2002)	1
LPXN	4	PTPN12	2	affinity chromatography technology	Huttlin EL (2017)	1
GP6	0	FYN	1	pull down	Suzuki-Inoue K (2002)	1
SRC	2	ITGB3	6	enzymatic study	Kirk RI (2000)	1
GRB2	2	ASAP2	5	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2017)	2
DLG4	11	ERBB2	6	two hybrid, affinity chromatography technology, biochemical	Huang YZ (2000), Huang YZ (2000), Huang YZ (2000)	3
SRC	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Narita T (2005), Schroeder B (2012)	2
PTPN6	0	LCK	0	enzymatic study, enzymatic study, pull down	Yu CL (2000), Chiang GG (2001), Lorenz U (1994)	3
JAK3	3	JAK2	1	affinity chromatography technology	Doucet C (2002)	1
SOCS3	0	RASA1	3	pull down, affinity chromatography technology	Cacalano NA (2001), Cacalano NA (2001)	2
PTPN12	2	TGFB1I1	2	affinity chromatography technology, pull down, two hybrid	Nishiya N (1999), Nishiya N (1999), Nishiya N (1999)	3
SRC	2	ERBB3	3	unspecified method	Jones RB (2006)	1
ERBB3	3	PTPN6	0	two hybrid	Yao Z (2017)	1
IL7R	2	SOCS2	1	affinity chromatography technology	Ghazawi FM (2016)	1
GSN	3	SRC	2	affinity chromatography technology	Chellaiah MA (2001)	1
NEDD9	3	PTPN12	2	pull down	Cote JF (1998)	1
HSP90AA1	7	JAK1	6	affinity chromatography technology	Taipale M (2012)	1
NEDD4	2	FYN	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
SKAP2	1	PTK2B	6	affinity chromatography technology, two hybrid, affinity chromatography technology	Takahashi T (2003), Takahashi T (2003), Takahashi T (2003)	3
NEDD9	3	LCK	0	affinity chromatography technology	Minegishi M (1996)	1
GP1BB	1	TGFB1I1	2	pull down, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
ERBB3	3	NEDD4	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Huang Z (2014), Huang Z (2014), Huang Z (2014), Verma N (2017)	4
PTK2B	6	ITGB2	4	affinity chromatography technology	Miura Y (2000)	1
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
GIT1	10	PTK2B	6	affinity chromatography technology	Ko J (2003)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
SRC	2	PTPN6	0	enzymatic study	Frank C (2004)	1
FYN	1	VAV1	2	affinity chromatography technology, two hybrid	Michel F (1998), Tartare-Deckert S (2001)	2
BCAR1	6	PXN	1	affinity chromatography technology, affinity chromatography technology	Salgia R (1996), Chellaiah MA (2001)	2
LCK	0	SOCS3	0	affinity chromatography technology	Venkitachalam S (2011)	1
PTPN12	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology	Charest A (1997), Charest A (1997), Bisson N (2011)	3
LPXN	4	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
SYK	3	VAV1	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Deckert M (1996), Deckert M (1996), Deckert M (1996), Song JS (1996), Bertagnolo V (2001), Bertagnolo V (2001), Tartare-Deckert S (2001)	7
PTK2B	6	JAK1	6	affinity chromatography technology	Benbernou N (2000)	1
EGFR	5	CBLB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Schulze WX (2006), Ettenberg SA (1999), Davies GC (2006), Davies GC (2006), Tong J (2009), Ettenberg SA (2001), Tong J (2008), Levkowitz G (1999), Tong J (2014)	9
HSP90AA1	7	ERBB3	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Li J (2013)	2
FYN	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
SYK	3	LYN	2	affinity chromatography technology, pull down	Sidorenko SP (1995), Sidorenko SP (1995)	2
RASA1	3	ERBB3	3	unspecified method	Jones RB (2006)	1
GRB2	2	SYK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Saci A (2002), de Castro RO (2012), de Castro RO (2012)	4
PTK2B	6	MAPT	1	enzymatic study	Virdee K (2007)	1
SOCS3	0	PTK2B	6	two hybrid, affinity chromatography technology	Masuhara M (1997), Zhang S (2008)	2
GRB2	2	RASA1	3	affinity chromatography technology	Lamprecht R (2002)	1
ERBB2	6	RASA1	3	unspecified method	Jones RB (2006)	1
NEDD4L	3	TGFB1I1	2	pull down	Persaud A (2009)	1
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
NPHP1	2	PTK2B	6	affinity chromatography technology, pull down	Benzing T (2001), Benzing T (2001)	2
EGFR	5	MAPT	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ASAP2	5	SRC	2	affinity chromatography technology	Andreev J (1999)	1
DLG4	11	KCNA2	6	two hybrid, pull down	Eldstrom J (2002), Eldstrom J (2002)	2
PTEN	24	PTK2B	6	affinity chromatography technology	Crockett DK (2005)	1
BCAR1	6	PTEN	24	pull down	Tamura M (1999)	1
PTK2B	6	IL7R	2	affinity chromatography technology	Benbernou N (2000)	1
PRKCD	2	FYN	1	imaging technique	Chen TC (2014)	1
PXN	1	LCK	0	affinity chromatography technology	Ostergaard HL (1998)	1
GNA13	0	PTK2B	6	affinity chromatography technology	Shi CS (2000)	1
ERBB3	3	JAK3	3	unspecified method	Jones RB (2006)	1
PTPN6	0	JAK1	6	enzymatic study	Yetter A (1995)	1
GP6	0	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
JAK2	1	PTPN12	2	affinity chromatography technology	Horsch K (2001)	1
FYN	1	JAK2	1	affinity chromatography technology, pull down	Sayeski PP (1999), Sayeski PP (1999)	2
ERBB2	6	JAK1	6	unspecified method	Jones RB (2006)	1
NEDD4	2	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology	Sette P (2010), Sette P (2010)	2
BCAR1	6	CBL	7	affinity chromatography technology	Sawasdikosol S (1996)	1
PTK2B	6	PITPNM1	11	two hybrid, affinity chromatography technology	Lev S (1999), Lev S (1999)	2
EGFR	5	SYK	3	unspecified method	Jones RB (2006)	1
EGFR	5	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
PTK2B	6	VAV1	2	pull down	Katagiri T (2000)	1
FYN	1	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tezuka T (1999), Hou XY (2002), Hou XY (2002)	3
PTEN	24	HSP90AA1	7	affinity chromatography technology, genetic interference	Maddika S (2011), Shen JP (2017)	2
SRC	2	SKAP2	1	enzymatic study	Takahashi T (2003)	1
RB1CC1	9	PTK2B	6	affinity chromatography technology, pull down, two hybrid, genetic interference	Ueda H (2000), Ueda H (2000), Ueda H (2000), Ueda H (2000)	4
ERBB3	3	VAV1	2	unspecified method	Jones RB (2006)	1
SRC	2	MAPT	1	enzymatic study	Bhaskar K (2005)	1
ERBB2	6	TLN1	5	unspecified method	Jones RB (2006)	1
ASAP2	5	PTK2B	6	pull down, affinity chromatography technology	Andreev J (1999), Andreev J (1999)	2
EWSR1	2	PTK2B	6	affinity chromatography technology, pull down	Felsch JS (1999), Felsch JS (1999)	2
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
TRAF4	1	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
EGFR	5	PTPN12	2	protein complementation assay, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Yao Z (2017)	5
GRB2	2	SKAP2	1	affinity chromatography technology	Brehme M (2009)	1
PXN	1	TLN1	5	pull down, pull down, affinity chromatography technology	Mazaki Y (1997), Salgia R (1995), Salgia R (1996)	3
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
SH3KBP1	1	PDCD6IP	3	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Schmidt MH (2004), Rauch S (2011), Havrylov S (2009), Usami Y (2007), Ichioka F (2007), Ichioka F (2007), Schmidt MH (2005), Carlton JG (2008), Chen B (2000)	9
FYN	1	GRIN2A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ma J (2003), Tezuka T (1999), Hou XY (2002), Hou XY (2002), Takagi N (1999), Takagi N (1999)	6
ASAP2	5	PXN	1	pull down	Kondo A (2000)	1
PTK2B	6	PTK2B	6	enzymatic study	Miyazaki T (1998)	1
PRKCD	2	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
DLG3	1	RB1CC1	9	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	JAK1	6	affinity chromatography technology	Tong J (2008)	1
SRC	2	TLN1	5	affinity chromatography technology	Lee J (2013)	1
IL7R	2	JAK3	3	affinity chromatography technology	Jahn T (2007)	1
TGFB1I1	2	PXN	1	affinity chromatography technology	Nishiya N (2001)	1
LCK	0	RASA1	3	enzymatic study	Giglione C (2001)	1
CBLB	3	SYK	3	affinity chromatography technology, enzymatic study	Elly C (1999), Wirnsberger G (2016)	2