PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DEFA1	0	NOTCH3	9	affinity chromatography technology	Huttlin EL (2017)	1
MPG	3	APP	1	pull down	Olah J (2011)	1
ADAMTSL2	3	FBLN1	1	two hybrid	Wang J (2011)	1
FBLN1	1	FGB	2	pull down	Tran H (1995)	1
TANK	1	APP	1	pull down	Olah J (2011)	1
PLSCR1	0	APP	1	pull down	Olah J (2011)	1
ATN1	2	NELL1	3	two hybrid	Lim J (2006)	1
TRIM25	5	EFEMP1	1	affinity chromatography technology	Choudhury NR (2017)	1
SMAD3	1	TANK	1	two hybrid	Wang J (2011)	1
FCN1	2	ELN	1	pull down	Harumiya S (1996)	1
PSG1	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
DDIAS	2	FBLN1	1	two hybrid	Won KJ (2017)	1
TYW3	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
NELL1	3	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBLN1	1	TANK	1	two hybrid	Wang J (2011)	1
IRF9	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
DDIAS	2	PLSCR1	0	two hybrid	Won KJ (2017)	1
NLGN3	3	FBLN1	1	two hybrid	Shen C (2015)	1
WNT4	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
APOA1	0	FN1	17	affinity chromatography technology	Zhou M (2004)	1
FBLN1	1	TCF7L2	12	two hybrid	Wang J (2011)	1
IFI30	2	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
FN1	17	FBLN1	1	pull down, two hybrid	Balbona K (1992), Wang J (2011)	2
LGALS9	0	NID1	6	affinity chromatography technology	Huttlin EL (2017)	1
ATN1	2	EFEMP1	1	two hybrid	Lim J (2006)	1
EDC4	4	FBLN1	1	two hybrid	Wang J (2011)	1
NLGN3	3	PSG3	2	two hybrid	Shen C (2015)	1
KCTD9	1	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
SMAD4	9	FBLN1	1	two hybrid	Colland F (2004)	1
FN1	17	SMAD4	9	two hybrid	Wang J (2011)	1
LGALS9	0	PTPRK	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOV	0	FN1	17	pull down	Ellis PD (2003)	1
FBLN1	1	TAF9	2	two hybrid	Wang J (2011)	1
PTPRK	1	FBLN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	YWHAQ	0	affinity chromatography technology	Humphries JD (2009)	1
ATN1	2	LTBP4	6	two hybrid	Lim J (2006)	1
TAF9	2	APP	1	pull down	Olah J (2011)	1
LGALS9	0	FBLN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOA1	0	FBLN1	1	two hybrid	Wang J (2011)	1
FBLN1	1	NEDD1	1	two hybrid	Wang J (2011)	1
NLGN3	3	PSG1	0	two hybrid	Shen C (2015)	1
SFRP4	1	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
OCLN	1	EFEMP1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBLN1	1	NOV	0	pull down, two hybrid	Perbal B (1999), Perbal B (1999)	2
PLSCR1	0	PLSCR4	0	two hybrid	Rual JF (2005)	1
MCPH1	4	FBLN1	1	two hybrid	Liu X (2017)	1
TRIM25	5	NELL1	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
PSG3	2	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
SMAD3	1	APP	1	pull down	Olah J (2011)	1
TRIM25	5	YWHAQ	0	affinity chromatography technology	Choudhury NR (2017)	1
FBLN1	1	YWHAQ	0	two hybrid	Wang J (2011)	1
SKIL	3	PSG3	2	two hybrid	Colland F (2004)	1
PSG3	2	PSG1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBLN1	1	LTBP4	6	two hybrid	Wang J (2011)	1
APP	1	FBLN1	1	two hybrid, pull down, affinity chromatography technology	Ohsawa I (2001), Ohsawa I (2001), Ohsawa I (2001)	3
ZNF517	0	LTBP4	6	affinity chromatography technology	Huttlin EL (2017)	1
ZNF517	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
BHLHE40	5	FBLN1	1	two hybrid	Wang J (2011)	1
TRIM25	5	ZFP41	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	FBLN1	1	affinity chromatography technology	Choudhury NR (2017)	1
DDIAS	2	EFEMP1	1	two hybrid	Won KJ (2017)	1
CACNA1A	21	FBLN1	1	two hybrid	Kahle JJ (2011)	1
WNT7A	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
FAM19A3	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
OCLN	1	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBLN1	1	TDGF1	0	two hybrid	Wang J (2011)	1
SMAD4	9	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (1999), Stroschein SL (1999), Barrios-Rodiles M (2005), Colland F (2004), Colland F (2004), He J (2003), He J (2003), Ikeuchi Y (2014), Jinnin M (2007), Li X (2015)	10
PLSCR4	0	FBLN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKIL	3	FBLN1	1	two hybrid	Colland F (2004)	1
CCDC89	1	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
LGALS9	0	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKIL	3	NID1	6	two hybrid	Colland F (2004)	1
PAK5	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
PLA2G10	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
ZFP41	0	NOTCH3	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COLQ	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
EFEMP1	1	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ATN1	2	affinity chromatography technology	Choudhury NR (2017)	1
WNT4	0	APP	1	pull down	Olah J (2011)	1
FBLN1	1	PLSCR1	0	two hybrid	Wang J (2011)	1
ZFP41	0	LTBP4	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
ATN1	2	PLSCR1	0	two hybrid	Lim J (2006)	1
FBLN1	1	NID1	6	pull down, pull down, pull down	Adam S (1997), Tran H (1997), Pan TC (1993)	3
ADAMTSL4	6	FBLN1	1	two hybrid	Wang J (2011)	1
GFI1B	1	FBLN1	1	two hybrid	Lim J (2006)	1
CACNA1A	21	NELL1	3	two hybrid	Kahle JJ (2011)	1
FBLN1	1	CTGF	1	pull down	Perbal B (1999)	1
DKK1	1	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
COLQ	0	FN1	17	affinity chromatography technology	Huttlin EL (2017)	1
FBLN1	1	SMAD3	1	two hybrid	Wang J (2011)	1
PLSCR1	0	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
NID1	6	FGB	2	pull down	Wu C (1991)	1
DEFA1	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBLN1	1	NOTCH3	9	two hybrid	Wang J (2011)	1
TRIM25	5	SMAD4	9	affinity chromatography technology	Choudhury NR (2017)	1
MPG	3	FBLN1	1	affinity chromatography technology	Ewing RM (2007)	1
APOA1	0	APP	1	pull down	Olah J (2011)	1
CACNA1A	21	EFEMP1	1	two hybrid	Kahle JJ (2011)	1
ATN1	2	FBLN1	1	two hybrid	Lim J (2006)	1
FN1	17	FGB	2	affinity chromatography technology	Moussavi-Harami SF (2013)	1
GFI1B	1	NELL1	3	two hybrid	Lim J (2006)	1
AGRP	0	FBLN1	1	affinity chromatography technology	Huttlin EL (2017)	1
CACNA1A	21	LTBP4	6	two hybrid	Kahle JJ (2011)	1
NELL1	3	TYW3	0	affinity chromatography technology	Huttlin EL (2017)	1
GFI1B	1	EFEMP1	1	two hybrid	Lim J (2006)	1
ZFP41	0	FBLN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSG1	0	NID1	6	affinity chromatography technology	Huttlin EL (2017)	1
FCN1	2	FBLN1	1	affinity chromatography technology	Huttlin EL (2015)	1
ELN	1	FBLN1	1	pull down	Sasaki T (1999)	1
NELL1	3	LTBP4	6	affinity chromatography technology	Huttlin EL (2017)	1
FBLN1	1	FBLN1	1	pull down	Tran H (1997)	1
GFI1B	1	LTBP4	6	two hybrid	Lim J (2006)	1