PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCL2L1	0	FBP1	2	two hybrid	Vinayagam A (2011)	1
FBP1	2	RNF183	0	two hybrid	Rual JF (2005)	1
ST6GALNAC5	1	FBP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP5J2	0	FBP1	2	two hybrid	Stelzl U (2005)	1
FBP1	2	KLRC2	0	two hybrid	Wang J (2011)	1
TIGD7	2	FBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
FBP1	2	FXR2	2	two hybrid	Rual JF (2005)	1
CSNK1E	0	FBP1	2	two hybrid	Vinayagam A (2011)	1
TERF1	1	FBP1	2	two hybrid	Lee OH (2011)	1
PRKN	1	FBP1	2	enzymatic study	Imam SZ (2011)	1
HDAC6	0	BIN1	2	affinity chromatography technology	Watson GW (2016)	1
PTK2	2	FBP1	2	two hybrid	Vinayagam A (2011)	1
SAMD7	1	FBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
ASCC2	3	FBP1	2	two hybrid	Stelzl U (2005)	1
FBP1	2	BIN1	2	unspecified method, pull down, two hybrid	Grelle G (2006), Grelle G (2006), Grelle G (2006)	3
DYNC1I1	1	FBP1	2	two hybrid	Vinayagam A (2011)	1
PRKN	1	ATP5J2	0	affinity chromatography technology	Zanon A (2013)	1
PTK2	2	BIN1	2	affinity chromatography technology	Messina S (2003)	1
FBP1	2	LNX1	7	two hybrid	Rual JF (2005)	1
ASL	1	FBP1	2	two hybrid	Wang J (2011)	1
FBP1	2	FBP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
441058	0	FBP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK1E	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
FBP1	2	PCNX4	2	two hybrid	Rual JF (2005)	1
FBP1	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Jin X (2017), Jin X (2017), Jin X (2017), Jin X (2017), Jin X (2017)	5
POT1	2	FBP1	2	two hybrid	Lee OH (2011)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
HDAC6	0	FBP1	2	two hybrid	Vinayagam A (2011)	1
GIMAP2	0	FBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	HSPA8	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2003), Zanon A (2013)	4
CCDC68	1	FBP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBP1	2	FBP1	2	two hybrid, two hybrid, x-ray crystallography, two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005), Ke HM (1990), Rolland T (2014), Yu H (2011)	5
SLAMF8	0	FBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
CROT	1	FBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	FBP1	2	two hybrid	Stelzl U (2005)	1
BCL2L1	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hollville E (2014), Hollville E (2014), Gong Y (2017), Gong Y (2017), Gong Y (2017)	5
HDAC6	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology	New M (2013), Watson GW (2016)	2