Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
KIF6	rs20455	AG + GG	pravastatin	efficacy	yes	This analysis has been published previously (PMID:18222353) for the White subset of this study (with primary endpoint of myocardial infarction). For this study, fatal coronary event and nonfatal myocardial infarction were both included as endpoints. Authors note that DNA for the genetic analysis was collected about 1.5 yrs after the CARE trial started, so the proportion of patients with fatal coronary events was higher in the non-DNA providers. Pravastatin dose was 40 mg/day. Response is compared to patients who received placebo.	Genotypes AG + GG are associated with increased response to pravastatin in people with Myocardial Infarction as compared to genotype AA.	20403483	981962878
KIF6	rs20455	AG + GG	atorvastatin	efficacy	yes		Genotypes AG + GG are associated with increased response to atorvastatin or pravastatin.	20886236	981482129
KIF6	rs9471077	AA	atorvastatin	efficacy	yes		Genotype AA is not associated with increased response to atorvastatin or pravastatin.	20886236	981482201
KIF6	rs9462535	CC	atorvastatin	efficacy	yes		Genotype CC is not associated with increased response to atorvastatin or pravastatin.	20886236	981482185
KIF6	rs9471077	AG + GG	atorvastatin	efficacy	yes		Genotypes AG + GG are associated with increased response to atorvastatin or pravastatin.	20886236	981482193
KIF6	rs9462535	AA + AC	atorvastatin	efficacy	yes		Genotypes AA + AC are associated with increased response to atorvastatin or pravastatin.	20886236	981482176
KIF6	rs20455	AA	atorvastatin	efficacy	yes		Genotype AA is not associated with increased response to atorvastatin or pravastatin.	20886236	981482167
KIF6	rs20455	GG	atorvastatin	efficacy	no	Please note that alleles have been complemented to the positive strand.	Genotype GG is associated with decreased response to atorvastatin, rosuvastatin or simvastatin in people with Hypercholesterolemia as compared to genotype AA.	30304062	1449748095
KIF6	rs20455	GG	atorvastatin	efficacy	yes	Please note that alleles have been complemented to the positive strand.	Genotype GG is associated with decreased response to atorvastatin or simvastatin in people with Hypercholesterolemia as compared to genotype AA.	30304062	1449748103
KIF6	rs20455	GG	simvastatin	efficacy	no	Please note that alleles have been complemented to the positive strand. A statistically significant association was seen between genotype and change in c-LDL levels, but no association was seen between genotype and change in c-HDL levels.	Genotype GG is associated with decreased response to simvastatin in people with Hypercholesterolemia as compared to genotype AA.	30304062	1449748065
KIF6	rs20455	GG	atorvastatin	efficacy	yes	Please note that alleles have been complemented to the positive strand. A statistically significant association was seen between genotype and change in c-Non-HDL levels, but no significant association was seen between genotype and change in c-LDL or c-HDL levels.	Genotype GG is associated with decreased response to atorvastatin in people with Hypercholesterolemia as compared to genotype AA.	30304062	1449748074
KIF6	rs20455	GG	rosuvastatin	efficacy	yes	Please note that alleles have been complemented to the positive strand. Statistically significant association only seen between genotype and change in c-HDL	Genotype GG is associated with decreased response to rosuvastatin in people with Hypercholesterolemia as compared to genotype AA.	30304062	1449748084