PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FN1	17	RPSA	2	affinity chromatography technology	Humphries JD (2009)	1
MCM2	3	RPS4X	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Drissi R (2015)	2
HDAC1	4	TLE3	2	biochemical	Wan C (2015)	1
OBSL1	9	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	RPSA	2	affinity chromatography technology	Hanson D (2014)	1
HIST1H2AA	1	HDAC3	5	pull down	Li X (2014)	1
OBSL1	9	RPS4X	0	affinity chromatography technology	Hanson D (2014)	1
EGFR	5	HIST1H2AA	1	affinity chromatography technology	Li J (2013)	1
RAD18	3	HIST1H2AA	1	affinity chromatography technology	Inagaki A (2011)	1
HIST1H3E	0	MCM2	3	affinity chromatography technology, affinity chromatography technology	Campos EI (2015), Drissi R (2015)	2
HIST1H2AA	1	HDAC1	4	pull down	Li X (2014)	1
MCM2	3	MAGOH	0	affinity chromatography technology	Drissi R (2015)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
HIST1H2BA	0	HDAC3	5	pull down	Li X (2014)	1
HIST1H2AA	1	HIST1H2BB	3	biochemical	Havugimana PC (2012)	1
HIST1H2BA	0	HDAC2	1	pull down, affinity chromatography technology	Li X (2014), Huttlin EL (2017)	2
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
FN1	17	EIF4A3	1	affinity chromatography technology	Humphries JD (2009)	1
RPS4X	0	RPSA	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
MCM5	1	HIST1H2AA	1	affinity chromatography technology	Drissi R (2015)	1
HIST1H2BA	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Li X (2014), Huttlin EL (2015), Huttlin EL (2017)	3
OBSL1	9	MCM5	1	affinity chromatography technology	Hanson D (2014)	1
RPS14	0	RPSA	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HIST1H2BA	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Drissi R (2015), Huttlin EL (2017)	3
HIST1H3E	0	RPS14	0	affinity chromatography technology	Campos EI (2015)	1
FN1	17	MCM2	3	affinity chromatography technology	Humphries JD (2009)	1
HIST1H3E	0	HIST1H2BB	3	affinity chromatography technology	Shuaib M (2010)	1
OBSL1	9	HIST1H2AA	1	affinity chromatography technology	Hanson D (2014)	1
HIST1H2AA	1	HIST1H2BA	0	biochemical	Havugimana PC (2012)	1
EGFR	5	FN1	17	protein complementation assay	Deribe YL (2009)	1
MCM5	1	HIST1H2BA	0	affinity chromatography technology	Drissi R (2015)	1
FN1	17	HIST1H2AA	1	affinity chromatography technology	Humphries JD (2009)	1
HIST1H2AA	1	RPS4X	0	biochemical	Havugimana PC (2012)	1
FN1	17	HDAC1	4	affinity chromatography technology	Humphries JD (2009)	1
MCM2	3	RPSA	2	affinity chromatography technology	Drissi R (2015)	1
PRKN	1	RPS14	0	affinity chromatography technology	Zanon A (2013)	1
MCM2	3	HIST1H2AA	1	affinity chromatography technology	Drissi R (2015)	1
FN1	17	RPS4X	0	affinity chromatography technology	Humphries JD (2009)	1
OBSL1	9	HDAC2	1	affinity chromatography technology	Hanson D (2014)	1
HIST1H2AA	1	RPSA	2	biochemical	Havugimana PC (2012)	1
MCM2	3	HIST1H2BB	3	affinity chromatography technology	Drissi R (2015)	1
DOT1L	7	HIST1H2BB	3	affinity chromatography technology	Park G (2010)	1
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
FN1	17	MCM5	1	affinity chromatography technology	Humphries JD (2009)	1
HIST1H3E	0	HIST1H2AA	1	affinity chromatography technology	Campos EI (2015)	1
HIST1H3E	0	MCM5	1	affinity chromatography technology	Campos EI (2015)	1
FN1	17	RPS14	0	affinity chromatography technology	Humphries JD (2009)	1
DOT1L	7	HIST1H2AA	1	affinity chromatography technology	Park G (2010)	1
MCM2	3	RPS14	0	affinity chromatography technology	Drissi R (2015)	1
HIST1H2AA	1	RPS14	0	biochemical	Havugimana PC (2012)	1
PRKN	1	HIST1H2AA	1	affinity chromatography technology	Zanon A (2013)	1
MAGOH	0	HIST1H2AA	1	affinity chromatography technology	Singh G (2012)	1
HIST1H2AA	1	TLE3	2	unspecified method	Flack JE (2017)	1
HIST1H2AA	1	HDAC2	1	pull down	Li X (2014)	1
ANP32B	0	HIST1H2BA	0	pull down	Munemasa Y (2008)	1
OBSL1	9	EIF4A3	1	affinity chromatography technology	Hanson D (2014)	1
EIF4A3	1	HIST1H2AA	1	affinity chromatography technology	Singh G (2012)	1
ANP32B	0	HIST1H2AA	1	pull down	Munemasa Y (2008)	1
HIST1H3E	0	HDAC1	4	affinity chromatography technology	Campos EI (2015)	1
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
FN1	17	ANP32B	0	affinity chromatography technology	Humphries JD (2009)	1
MAGOH	0	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Singh G (2012), Singh G (2012), Barbosa I (2012)	7
MCM5	1	HIST1H2BB	3	affinity chromatography technology	Drissi R (2015)	1
RPS4X	0	RPS14	0	pull down, biochemical, biochemical, biochemical	Winkelmann DA (1983), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4