PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KDM1B	4	WDR5	2	affinity chromatography technology	Fang R (2010)	1
BMI1	0	KDM1B	4	genetic interference	Wong AS (2016)	1
SMC1A	15	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Fang R (2010), Fang R (2010)	2
KDM1B	4	COX5A	0	affinity chromatography technology	Hein MY (2015)	1
NSD3	6	HIST3H3	0	pull down, pull down, x-ray crystallography	He C (2013), He C (2013), He C (2013)	3
KDM1B	4	DYNC1I2	0	affinity chromatography technology	Hein MY (2015)	1
BAP1	4	FOXK2	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Okino Y (2015), Okino Y (2015), Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014), Ji Z (2014), Shan L (2016), Shan L (2016), Shan L (2016), Hauri S (2016)	15
ASXL2	6	KDM1B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	4
KDM1B	4	CEP192	5	affinity chromatography technology	Hein MY (2015)	1
NDUFA10	2	KDM1B	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASXL2	6	OGT	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
OGT	4	WDR5	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
FOXK2	9	KDM1B	4	affinity chromatography technology	Li X (2015)	1
SPATA17	0	KDM1B	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EHMT2	4	HIST3H3	0	enzymatic study	Shi Y (2003)	1
8339	0	NSD3	6	bioid	Lambert JP (2015)	1
GLYR1	3	KDM1B	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KDM1B	4	NSD3	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fang R (2010), Fang R (2010), Hein MY (2015), Hein MY (2015)	4
HIST1H3A	3	GLYR1	3	pull down	Sankaran SM (2016)	1
FAM19A3	0	KDM1B	4	affinity chromatography technology	Huttlin EL (2017)	1
8339	0	EHMT2	4	bioid	Lambert JP (2015)	1
SMC1A	15	KDM1B	4	affinity chromatography technology	Fang R (2010)	1
KDM1B	4	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Fang R (2010), Fang R (2010)	2
KDM1B	4	HEATR3	1	affinity chromatography technology	Hein MY (2015)	1
HIST1H3A	3	WDR5	2	affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006), Schuetz A (2006), Couture JF (2006), Ruthenburg AJ (2006), Han Z (2006), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Bailey JK (2015)	11
HIST1H3A	3	EHMT2	4	pull down, enzymatic study, enzymatic study	Chin HG (2005), Chin HG (2005), Huang J (2010)	3
HIST3H3	0	GLYR1	3	unspecified method	Vermeulen M (2010)	1
KDM1B	4	OGT	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang Y (2015), Yang Y (2015), Yang Y (2015)	3
KDM1B	4	CCNT1	3	affinity chromatography technology, affinity chromatography technology	Fang R (2010), Fang R (2010)	2
BAP1	4	ASXL2	6	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Huttlin EL (2015), Daou S (2015), Daou S (2015), Daou S (2015), Daou S (2015), Daou S (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	12
PAXIP1	1	SMC1A	15	affinity chromatography technology	Patel SR (2007)	1
PAXIP1	1	HIST1H3A	3	enzymatic study	Patel SR (2007)	1
SH2D2A	2	KDM1B	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BMI1	0	HIST1H3A	3	affinity chromatography technology	Abdouh M (2016)	1
BMI1	0	WDR5	2	affinity chromatography technology	Cao Q (2014)	1
KDM1B	4	PAXIP1	1	affinity chromatography technology	Fang R (2010)	1
KDM1B	4	CASC3	0	affinity chromatography technology	Hein MY (2015)	1
BAP1	4	OGT	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yu H (2010), Mashtalir N (2014), Daou S (2015), Hauri S (2016), Hauri S (2016)	6
WDR5	2	HIST3H3	0	enzymatic study, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Cao F (2010), Avdic V (2011), Avdic V (2011), Kim JY (2014), Kim JY (2014), Kim JY (2014), Dias J (2014)	7
KDM1B	4	CPSF3	5	affinity chromatography technology	Hein MY (2015)	1
PAXIP1	1	CPSF3	5	affinity chromatography technology	Woods NT (2012)	1
GLYR1	3	NSD3	6	two hybrid	Weimann M (2013)	1
EHMT2	4	WDR5	2	affinity chromatography technology	Hauri S (2016)	1
8339	0	KDM1B	4	bioid	Lambert JP (2015)	1
HAVCR2	0	KDM1B	4	affinity chromatography technology	Huttlin EL (2017)	1
HIST3H3	0	BMI1	0	unspecified method	Vermeulen M (2010)	1
CCNT1	3	NSD3	6	affinity chromatography technology	Fang R (2010)	1
NSD3	6	HIST1H3A	3	enzymatic study, pull down	Morishita M (2014), Sankaran SM (2016)	2
KDM1B	4	KDM1B	4	enzymatic study	Yang Y (2015)	1
HIST1H3A	3	KDM1B	4	bioid	Lambert JP (2015)	1
UBE2D3	1	KDM1B	4	pull down, pull down	Yang Y (2015), Yang Y (2015)	2
BMI1	0	CASC3	0	affinity chromatography technology	Cao Q (2014)	1
PAXIP1	1	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	9
FOXK2	9	ASXL2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Daou S (2015), Ji Z (2014), Hauri S (2016)	4
BMI1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Bentley ML (2011), Li Z (2006), Zhang Y (2014), Taherbhoy AM (2015)	4
BAP1	4	KDM1B	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Hein MY (2015), Hauri S (2016)	5
KDM1B	4	HIST3H3	0	enzymatic study	Yang Y (2015)	1