PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
APP	1	FES	2	pull down	Virok DP (2011)	1
FKBP5	0	APP	1	pull down	Olah J (2011)	1
FES	2	PPID	0	pull down	Nair SC (1996)	1
EGFR	5	FKBP4	0	protein complementation assay	Deribe YL (2009)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
FES	2	FKBP4	0	pull down	Nair SC (1996)	1
HSP90AA1	7	STAT3	0	affinity chromatography technology	Sato N (2003)	1
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
PIK3R1	6	FES	2	affinity chromatography technology	Izuhara K (1996)	1
TERF1	1	FES	2	two hybrid	Lee OH (2011)	1
FES	2	PDE4DIP	10	two hybrid	Vinayagam A (2011)	1
TRIM28	1	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology	Tsuruma R (2008), Tsuruma R (2008), Tsuruma R (2008)	3
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
HSH2D	1	FES	2	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Oda T (2001), Oda T (2001), Oda T (2001), Oda T (2001)	4
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
HSP90AA1	7	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun H (2011), Tsukahara F (2010), Wu LX (2006)	3
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
STAT3	0	PIK3R1	6	two hybrid	Grossmann A (2015)	1
HSP90AA1	7	PPID	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down	Schuelke JP (2010), Park MS (2011), Shimamoto S (2010), Shimamoto S (2010), Graumann K (2000)	5
FES	2	HSPA4	3	pull down	Nair SC (1996)	1
PPID	0	APP	1	pull down	Olah J (2011)	1
EGFR	5	TRIM28	1	affinity chromatography technology	Liccardi G (2014)	1
FES	2	ZNF746	0	two hybrid	Vinayagam A (2011)	1
FES	2	HSP90AA1	7	pull down, affinity chromatography technology	Nair SC (1996), Taipale M (2012)	2
FES	2	FKBP5	0	pull down	Nair SC (1996)	1
FKBP4	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Li J (2011), Esposito V (2012), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Shimamoto S (2010), Shimamoto S (2010), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Graumann K (2000), Sun L (2012), Huttlin EL (2017)	14
FKBP4	0	HSPA4	3	pull down	Graumann K (2000)	1
FES	2	STAT3	0	affinity chromatography technology	Park WY (1998)	1
BCR	3	HSPA4	3	affinity chromatography technology	Wu LX (2006)	1
FES	2	MDFI	1	two hybrid	Venkatesan K (2009)	1
HSP90AA1	7	PTGES3	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down	McLaughlin SH (2002), Mollapour M (2010), Kovacs JJ (2005), Giommarelli C (2010), Tsutsumi S (2012), Lee YT (2004), Schuelke JP (2010), Sarkar S (2012), Gano JJ (2010), Zelin E (2012), Obermann WM (1998), Wang J (2011), Weaver AJ (2000), Donze O (2001), Shimamura T (2012), Chan CT (2008), Chan CT (2008), Graumann K (2000), Martinez-Yamout MA (2006), Chadli A (2010), Woo SH (2009), Woo SH (2009), Woo SH (2009), Ni L (2010), Chadli A (2008), Picard D (2006), Wochnik GM (2004), Woodford MR (2016), Scholz GM (2001), McLaughlin SH (2006), Sun L (2012), Woodford MR (2016), Lepvrier E (2015)	33
FKBP4	0	PTGES3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Scholz GM (2001)	3
PPID	0	PTGES3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Scholz GM (2001)	3
SMURF1	4	TRIM28	1	affinity chromatography technology	Xie Y (2013)	1
FES	2	TRIM28	1	two hybrid, pull down, affinity chromatography technology, enzymatic study	Delfino FJ (2006), Delfino FJ (2006), Delfino FJ (2006), Delfino FJ (2006)	4
BCR	3	PTGES3	0	affinity chromatography technology	Wu LX (2006)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
EGFR	5	STAT3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Yuan ZL (2004), Olayioye MA (1999), Lo HW (2005), Lo HW (2005), Crovello CS (1998), Jaganathan S (2011), Jaganathan S (2011), Andl CD (2004), Lo HW (2010), Foerster S (2013), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), de la Iglesia N (2008), Fan QW (2013), Fan QW (2013)	18
EGFR	5	PTGES3	0	affinity chromatography technology	Tong J (2014)	1
FES	2	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lionberger JM (2000), Lionberger JM (2000), Maru Y (1995), Maru Y (1995)	4
SMURF1	4	APP	1	pull down	Olah J (2011)	1
SMURF1	4	FES	2	enzymatic study	Andrews PS (2010)	1
FES	2	FES	2	pull down	McDonald NA (2015)	1
PTGES3	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schuelke JP (2010), Taipale M (2014), Taipale M (2014)	3
NEDD4	2	FES	2	pull down	Persaud A (2009)	1
POT1	2	FES	2	two hybrid	Lee OH (2011)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
ZNF746	0	TRIM28	1	affinity chromatography technology	Kang H (2015)	1
FES	2	ZNF775	4	two hybrid	Vinayagam A (2011)	1
EGFR	5	FES	2	unspecified method	Jones RB (2006)	1
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
BCR	3	PIK3R1	6	far western blotting	Weinger JG (2008)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
HSPA4	3	FKBP5	0	affinity chromatography technology	Schuelke JP (2010)	1
PSMD13	1	FES	2	affinity chromatography technology	Ewing RM (2007)	1
FES	2	DSP	8	affinity chromatography technology	So J (2015)	1
TERF1	1	HSPA4	3	affinity chromatography technology	Giannone RJ (2010)	1
FES	2	PTGES3	0	pull down	Nair SC (1996)	1