PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
FGFR2	6	FGFR1	2	affinity chromatography technology	Huttlin EL (2017)	1
FGF1	0	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGF1	0	GPC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGF1	0	SDC4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGF1	0	HSPA9	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Mizukoshi E (1999), Mizukoshi E (1999), Mizukoshi E (1999), Mizukoshi E (1999)	4
FGF1	0	SDC2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SDC2	0	FGFR3	7	affinity chromatography technology	Huttlin EL (2017)	1
FGF1	0	RCOR1	0	affinity chromatography technology	Huttlin EL (2015)	1
FGF1	0	GPC6	1	affinity chromatography technology	Huttlin EL (2015)	1
FGFR2	6	FGFR3	7	affinity chromatography technology	Huttlin EL (2017)	1
FGF1	0	FGFR4	6	pull down, pull down, imaging technique, pull down	Loo BB (2000), Kan M (1999), Chen TC (2014), Ostrovsky O (2002)	4
CSNK2A2	1	KDM1A	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Peng B (2015), Peng B (2015), Peng B (2015), Peng B (2015)	4
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
FGF1	0	KDM1A	2	affinity chromatography technology	Huttlin EL (2015)	1
HMG20A	0	GSE1	14	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CLDN10	0	FGF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
S100A13	0	FGF1	0	biochemical, pull down	Mouta Carreira C (1998), Landriscina M (2001)	2
HMG20A	0	RCOR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	4
SDC2	0	FGFR2	6	affinity chromatography technology	Huttlin EL (2017)	1
S100A13	0	SYT1	4	biochemical, pull down	Mouta Carreira C (1998), Landriscina M (2001)	2
CSNK2A1	15	KDM1A	2	affinity chromatography technology	Peng B (2015)	1
FGFR3	7	FGF1	0	pull down, pull down, pull down	Santos-Ocampo S (1996), Chellaiah A (1999), Bojesen KB (2012)	3
GSE1	14	RCOR3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
KDM1A	2	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi YJ (2005), Bantscheff M (2011), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	6
FGF1	0	GPC3	0	affinity chromatography technology	Huttlin EL (2017)	1
FGF1	0	CSNK2A2	1	pull down, pull down	Skjerpen CS (2002), Skjerpen CS (2002)	2
FGF1	0	CSNK2B	5	affinity chromatography technology, pull down	Skjerpen CS (2002), Skjerpen CS (2002)	2
FGF1	0	EGFLAM	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK2B	5	CSNK2A2	1	two hybrid, affinity chromatography technology, far western blotting, two hybrid, enzymatic study, biochemical, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lehner B (2004), Kim MS (1998), Marin O (1997), Bosc DG (2000), Watabe M (2011), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Goetz C (1999), Hauri S (2016)	13
HMG20A	0	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
FGF1	0	FGFR2	6	x-ray crystallography, x-ray crystallography, pull down, imaging technique, unspecified method, pull down, pull down	Stauber DJ (2000), Pellegrini L (2000), Santos-Ocampo S (1996), Chen TC (2014), Li S (2008), Bojesen KB (2012), Ostrovsky O (2002)	7
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
FGF1	0	FGFR1	2	x-ray crystallography, pull down, imaging technique, unspecified method, pull down, pull down, pull down, pull down, pull down, pull down	Schlessinger J (2000), Santos-Ocampo S (1996), Chen TC (2014), Li S (2008), Bojesen KB (2012), Ostrovsky O (2002), Shi E (1993), Lopez ME (2000), Levi E (1996), Dikov MM (1998)	10
SDC2	0	S100A13	0	affinity chromatography technology	Huttlin EL (2017)	1
SYT1	4	FGF1	0	pull down	Landriscina M (2001)	1
FGF1	0	FIBP	1	two hybrid, pull down	Kolpakova E (1998), Kolpakova E (1998)	2
CSNK2A2	1	SDC2	0	affinity chromatography technology	Varjosalo M (2013)	1
TGFBR3	1	FGFR1	2	affinity chromatography technology	Knelson EH (2013)	1
FGFBP1	2	FGF1	0	pull down	Tassi E (2001)	1
FGF1	0	HMG20A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGF1	0	TGFBR3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGF1	0	CSNK2A1	15	pull down, pull down, enzymatic study	Skjerpen CS (2002), Skjerpen CS (2002), Skjerpen CS (2002)	3
FGF1	0	RCOR3	0	affinity chromatography technology	Huttlin EL (2015)	1
KDM1A	2	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Lee MG (2005), Bantscheff M (2011)	3
FGF1	0	FGF1	0	x-ray crystallography	DiGabriele AD (1998)	1