Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
FHIT	2272	FRUCTOSE	CHEMBL604608		DrugBank	17139284, 17016423
FHIT	2272	TRICHOSTATIN	CHEMBL99		NCI	17019711

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
FHIT	rs241692	G	bevacizumab	efficacy	no	The authors performed GWAS in a discovery cohort, and did a replication analysis.	Allele G is not associated with response to bevacizumab and ranibizumab in people with as compared to allele A.	29852030	1449566994
FHIT	rs760316	C	interferon beta-1a	efficacy	yes	In the discovery GWAS stage, the Bonferroni adjusted statistical significance threshold was <=1.74E-10, however no SNPs reached this level, likely due to sample size limitations, and so the significance level was set at <=1.0E-3. In the validation stage, the significance level was set at <0.05, and SNPs that did not have the same direction of response as the discovery stage were considered spurious associations and omitted from further analysis. In further validation in a cohort treated with glutiramer acetate (GA), this SNP was not associated with response. Response was defined as no relapses and no change on Kurtzke Expanded Disability Status Scale (EDSS) scores in the 2 years after starting interferon beta therapy. Non-reponse defined as having >= 2 relapses or an increase in EDSS by at least 1 point in the 2 years follow-up after a minimum duration of 6 months post initiation of therapy.	Allele C is associated with increased response to interferon beta-1a and interferon beta-1b in people with Multiple Sclerosis as compared to allele T.	27001119	1447959603
FHIT	rs49411	C	antidepressants	efficacy	yes	Identity of minor allele not specified, so minor allele of dbSNP used here. Response measured at >50% reduction in symptoms at discharge of the Hamilton Rating Scale for Depression (HRSD17). Patients measured at admission and discharge, 4-6 weeks later. Specific antidepressants not listed.	Allele C is associated with decreased response to antidepressants in people with Depressive Disorder, Major as compared to allele T.	27091189	1447983283