PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MOV10	6	NKRF	1	affinity chromatography technology	Castello A (2012)	1
NPHP3	2	NPHP1	2	affinity chromatography technology	Olbrich H (2003)	1
USP36	4	10607	0	affinity chromatography technology	Sowa ME (2009)	1
FAM19A3	0	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
NPHP1	2	DBT	0	bioid	Gupta GD (2015)	1
CEP164	6	NMD3	2	bioid	Gupta GD (2015)	1
TRA2B	3	DDX47	0	biochemical	Wan C (2015)	1
ATRIP	1	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2003), Wang Y (2003), Cortez D (2004), Cortez D (2001), Cortez D (2001), Cortez D (2001), Cortez D (2001), Rendtlew Danielsen JM (2009), Kulkarni A (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008), Itakura E (2004), Itakura E (2004), Itakura E (2004), Pabla N (2008), Pabla N (2011), Collis SJ (2007), Collis SJ (2007), Warmerdam DO (2010), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Bomgarden RD (2004), Choi JH (2007), Lovejoy CA (2009), Huttlin EL (2017)	27
SNU13	0	TRA2B	3	biochemical	Havugimana PC (2012)	1
SYCE3	0	NIN	4	affinity chromatography technology	Huttlin EL (2017)	1
NPHP1	2	SRSF2	0	bioid	Gupta GD (2015)	1
NPHP4	10	CEP164	6	affinity chromatography technology, affinity chromatography technology	Chaki M (2012), Chaki M (2012)	2
CEP164	6	RBFOX2	5	bioid	Gupta GD (2015)	1
SENP3	1	NSUN2	0	affinity chromatography technology	Wang M (2016)	1
CEP128	1	DVL3	7	bioid	Gupta GD (2015)	1
UBC	7	PEF1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), McGourty CA (2016)	2
CEP128	1	NUP205	3	bioid	Gupta GD (2015)	1
ELAVL1	0	CCDC92	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP164	6	SRSF10	0	bioid	Gupta GD (2015)	1
CEP164	6	DBT	0	bioid	Gupta GD (2015)	1
CEBPZ	4	EBNA1BP2	0	biochemical	Wan C (2015)	1
OFD1	3	SRSF2	0	bioid	Gupta GD (2015)	1
CEP164	6	SNU13	0	bioid	Gupta GD (2015)	1
DDX56	0	CEBPZ	4	biochemical	Wan C (2015)	1
SYCE3	0	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	CEP164	6	affinity chromatography technology	Abdelmohsen K (2009)	1
DDX56	0	RPF2	1	biochemical	Wan C (2015)	1
CEP89	2	NPHP4	10	bioid	Gupta GD (2015)	1
CEP164	6	WDR3	0	bioid	Gupta GD (2015)	1
SRSF2	0	TRA2B	3	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
OFD1	3	CEP164	6	bioid	Gupta GD (2015)	1
NPHP3	2	CEP164	6	affinity chromatography technology, affinity chromatography technology	Chaki M (2012), Chaki M (2012)	2
ELAVL1	0	CRYL1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP164	6	AATF	0	bioid	Gupta GD (2015)	1
DDX24	1	RPF2	1	biochemical	Wan C (2015)	1
CEP164	6	EBNA1BP2	0	bioid	Gupta GD (2015)	1
NPHP4	10	INVS	2	bioid	Gupta GD (2015)	1
EBNA1BP2	0	DDX56	0	biochemical	Wan C (2015)	1
CEP164	6	PPM1F	1	bioid	Gupta GD (2015)	1
CEP164	6	RFC2	0	bioid	Gupta GD (2015)	1
IDH3B	0	DBT	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EBNA1BP2	0	DDX24	1	biochemical	Wan C (2015)	1
CEP164	6	ATRIP	1	affinity chromatography technology, affinity chromatography technology, pull down	Sivasubramaniam S (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008)	3
CEP164	6	RPP38	0	bioid	Gupta GD (2015)	1
NIN	4	ECH1	2	bioid	Gupta GD (2015)	1
CEP164	6	SUPT16H	4	bioid	Gupta GD (2015)	1
CEP164	6	DDX23	3	bioid	Gupta GD (2015)	1
CEP164	6	C1orf131	2	bioid	Gupta GD (2015)	1
CEP164	6	TTBK2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Chaki M (2012), Chaki M (2012), Chaki M (2012)	3
MOV10	6	CDC16	2	affinity chromatography technology	Castello A (2012)	1
MOV10	6	CEP164	6	affinity chromatography technology	Castello A (2012)	1
CEP164	6	IDH3B	0	bioid	Gupta GD (2015)	1
BBS7	2	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
CEP164	6	MTPN	0	bioid	Gupta GD (2015)	1
CEP164	6	LONP1	9	bioid	Gupta GD (2015)	1
MOV10	6	NUP205	3	affinity chromatography technology	Castello A (2012)	1
NIN	4	SNU13	0	bioid	Gupta GD (2015)	1
UBC	7	RFC2	0	affinity chromatography technology	Matsumoto M (2005)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	IDH3B	0	bioid	Gupta GD (2015)	1
CEP164	6	TOP2B	9	bioid	Gupta GD (2015)	1
ELAVL1	0	MTPN	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP128	1	DBT	0	bioid	Gupta GD (2015)	1
THSD4	1	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
RNASEH2B	0	CEP164	6	affinity chromatography technology	Hein MY (2015)	1
CEP164	6	SENP3	1	bioid	Gupta GD (2015)	1
CEP164	6	NCBP3	1	bioid	Gupta GD (2015)	1
MOV10	6	SUPT16H	4	affinity chromatography technology	Castello A (2012)	1
SHMT2	3	NUP205	3	affinity chromatography technology	Castello A (2012)	1
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
DDX24	1	DDX56	0	biochemical	Wan C (2015)	1
CEP128	1	DDX47	0	bioid	Gupta GD (2015)	1
NIN	4	PCM1	5	bioid	Gupta GD (2015)	1
OFD1	3	IDH3B	0	bioid	Gupta GD (2015)	1
CEP164	6	NKRF	1	bioid	Gupta GD (2015)	1
SNU13	0	DDX56	0	biochemical	Wan C (2015)	1
SHMT2	3	DDX24	1	affinity chromatography technology	Castello A (2012)	1
NIN	4	CEP164	6	bioid	Gupta GD (2015)	1
CEP128	1	PEF1	0	bioid	Gupta GD (2015)	1
OFD1	3	NIN	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MOV10	6	DDX24	1	affinity chromatography technology	Castello A (2012)	1
CEP164	6	BTF3	4	bioid	Gupta GD (2015)	1
RALBP1	2	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
SNU13	0	SRSF10	0	biochemical	Havugimana PC (2012)	1
CEP128	1	ECH1	2	bioid	Gupta GD (2015)	1
EBNA1BP2	0	AATF	0	biochemical	Wan C (2015)	1
CEP128	1	GPX1	0	bioid	Gupta GD (2015)	1
CEP164	6	PDCD11	5	bioid	Gupta GD (2015)	1
PCM1	5	BTF3	4	bioid	Gupta GD (2015)	1
PCM1	5	CCDC92	1	bioid	Gupta GD (2015)	1
ELAVL1	0	NIN	4	affinity chromatography technology	Abdelmohsen K (2009)	1
PCM1	5	CEP89	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
TOP2B	9	SUPT16H	4	biochemical	Wan C (2015)	1
SHMT2	3	GLUD2	1	affinity chromatography technology	Castello A (2012)	1
BTF3	4	LONP1	9	genetic interference	Horlbeck MA (2018)	1
SNU13	0	SUPT16H	4	biochemical	Havugimana PC (2012)	1
LIPH	1	CEP164	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
MOV10	6	GLUD2	1	affinity chromatography technology	Castello A (2012)	1
CEP164	6	STX8	0	bioid	Gupta GD (2015)	1
CEP164	6	MAPK14	0	two hybrid	Wang J (2011)	1
NPHP1	2	NPHP4	10	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Mollet G (2002), Gupta GD (2015), Gupta GD (2015), Boldt K (2016)	4
CELA1	3	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
CEP164	6	CAPN1	3	bioid	Gupta GD (2015)	1
CEP164	6	CCDC92	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Chaki M (2012), Chaki M (2012), Chaki M (2012)	3
CEP128	1	NPHP4	10	bioid	Gupta GD (2015)	1
10607	0	AATF	0	biochemical	Wan C (2015)	1
CEP164	6	CEBPZ	4	bioid	Gupta GD (2015)	1
DDX24	1	SNU13	0	biochemical	Wan C (2015)	1
ELAVL1	0	RFWD2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SNU13	0	SSR3	0	biochemical	Havugimana PC (2012)	1
DVL3	7	CEP164	6	affinity chromatography technology, affinity chromatography technology	Chaki M (2012), Chaki M (2012)	2
ELAVL1	0	PPM1F	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP164	6	TRA2B	3	bioid	Gupta GD (2015)	1
CEP164	6	NUP205	3	bioid	Gupta GD (2015)	1
SENP3	1	SSRP1	1	affinity chromatography technology	Wang M (2016)	1
CEP128	1	SRSF2	0	bioid	Gupta GD (2015)	1
CEP164	6	CTSB	5	bioid	Gupta GD (2015)	1
CEP164	6	SSRP1	1	bioid	Gupta GD (2015)	1
CEP164	6	VN1R5	0	bioid	Gupta GD (2015)	1
CEP128	1	CEP164	6	bioid	Gupta GD (2015)	1
WDR3	0	10607	0	biochemical	Wan C (2015)	1
CEP164	6	100652748	0	bioid	Gupta GD (2015)	1
SNU13	0	ZNF326	3	biochemical	Havugimana PC (2012)	1
OFD1	3	100652748	0	bioid	Gupta GD (2015)	1
CEP164	6	SRSF2	0	bioid	Gupta GD (2015)	1
INVS	2	NPHP1	2	affinity chromatography technology, affinity chromatography technology	Otto EA (2003), Otto EA (2003)	2
CEP128	1	NPHP1	2	bioid	Gupta GD (2015)	1
CEP164	6	SSR3	0	bioid	Gupta GD (2015)	1
CEP164	6	YY1	7	bioid	Gupta GD (2015)	1
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
CEP164	6	ECH1	2	bioid	Gupta GD (2015)	1
CEP164	6	NSUN2	0	bioid	Gupta GD (2015)	1
CEP164	6	CSRP2	0	bioid	Gupta GD (2015)	1
NIN	4	DBT	0	bioid	Gupta GD (2015)	1
THSD4	1	OFD1	3	affinity chromatography technology	Huttlin EL (2017)	1
CEP164	6	DDX47	0	bioid	Gupta GD (2015)	1
CEP89	2	OFD1	3	bioid	Gupta GD (2015)	1
CEP164	6	DDX56	0	bioid	Gupta GD (2015)	1
MOV10	6	SENP3	1	biochemical	Havugimana PC (2012)	1
PCM1	5	CEP164	6	bioid	Gupta GD (2015)	1
LDHD	6	CEP164	6	affinity chromatography technology	Hein MY (2015)	1
MOV10	6	NVL	5	affinity chromatography technology	Castello A (2012)	1
ELAVL1	0	SUPT16H	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ATR	6	CEP164	6	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sivasubramaniam S (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008)	4
USP36	4	WDR3	0	affinity chromatography technology	Sowa ME (2009)	1
CEP164	6	USP36	4	bioid	Gupta GD (2015)	1
NPHP1	2	IDH3B	0	bioid	Gupta GD (2015)	1
UBC	7	CCDC92	1	pull down	Zhang X (2017)	1
CEP164	6	GLUD2	1	bioid	Gupta GD (2015)	1
ELAVL1	0	YY1	7	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP164	6	NVL	5	bioid	Gupta GD (2015)	1
UBC	7	USP36	4	pull down	Kwasna D (2018)	1
ELAVL1	0	RBFOX2	5	affinity chromatography technology, two hybrid, two hybrid	Abdelmohsen K (2009), Hegele A (2012), Hegele A (2012)	3
CEP164	6	ZNF326	3	bioid	Gupta GD (2015)	1
BTF3	4	SRSF2	0	biochemical	Wan C (2015)	1
NPHP1	2	CEP164	6	affinity chromatography technology	Chaki M (2012)	1
TRA2B	3	SRSF10	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
AATF	0	RPF2	1	biochemical	Wan C (2015)	1
PCM1	5	NOL11	0	bioid	Gupta GD (2015)	1
INVS	2	CEP164	6	affinity chromatography technology	Chaki M (2012)	1
NCAPH2	4	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
DDX56	0	AATF	0	biochemical	Wan C (2015)	1
DDX24	1	10607	0	biochemical	Wan C (2015)	1
CRYL1	0	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
CEP164	6	PEF1	0	bioid	Gupta GD (2015)	1
DDX56	0	10607	0	biochemical	Wan C (2015)	1
MOV10	6	IDH3B	0	affinity chromatography technology	Castello A (2012)	1
NCAPH2	4	OFD1	3	affinity chromatography technology	Huttlin EL (2017)	1
CEP164	6	NOL11	0	bioid	Gupta GD (2015)	1
OFD1	3	LONP1	9	bioid	Gupta GD (2015)	1
CEP89	2	CEP164	6	bioid	Gupta GD (2015)	1
RFWD2	0	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	DNAJB6	3	affinity chromatography technology	Matsumoto M (2005)	1
CEP164	6	GPX1	0	bioid	Gupta GD (2015)	1
FAM19A3	0	MAPK14	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	CEP164	6	pull down	Nathan JA (2013)	1
CEP128	1	NIN	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP164	6	PDS5B	3	bioid	Gupta GD (2015)	1
SHMT2	3	CEP164	6	affinity chromatography technology	Castello A (2012)	1
SNU13	0	YY1	7	biochemical	Havugimana PC (2012)	1
CEP164	6	DDX24	1	bioid	Gupta GD (2015)	1
CEP164	6	10607	0	bioid	Gupta GD (2015)	1
CEP164	6	DNAJB6	3	bioid	Gupta GD (2015)	1
CDC16	2	CEP164	6	affinity chromatography technology	Huttlin EL (2017)	1
CEP164	6	RPF2	1	bioid	Gupta GD (2015)	1
EBNA1BP2	0	RPF2	1	biochemical	Wan C (2015)	1