PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BBS1	2	BBS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
ATP6V1E1	0	ALDOB	2	two hybrid	Lu M (2001)	1
BBS1	2	BBS7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
BBS7	2	ALDOB	2	two hybrid, affinity chromatography technology	Oeffner F (2008), Oeffner F (2008)	2
ALDOB	2	HIVEP1	13	two hybrid	Wang J (2011)	1
ALDOB	2	MUC20	4	two hybrid	Wang J (2011)	1
BBS1	2	BBS4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
BBS7	2	BBS4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
RPE	3	ALDOB	2	biochemical	Wan C (2015)	1
ALDOA	0	ALDOB	2	two hybrid	Wang J (2011)	1
BBS2	1	BBS4	2	affinity chromatography technology	Boldt K (2016)	1
SUMO3	0	ALDOB	2	biochemical	Wan C (2015)	1
ATP6V1E1	0	ALDOA	0	two hybrid	Lu M (2001)	1
BBS7	2	BBS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
AGXT2	1	ALDOB	2	two hybrid	Wang J (2011)	1
BBS4	2	ALDOB	2	two hybrid, affinity chromatography technology	Oeffner F (2008), Oeffner F (2008)	2
ALDOB	2	TXN2	0	two hybrid	Wang J (2011)	1
ATP6V1E1	0	APP	1	pull down	Olah J (2011)	1
BBS2	1	ALDOB	2	two hybrid, affinity chromatography technology	Oeffner F (2008), Oeffner F (2008)	2
ALDOB	2	APP	1	pull down	Olah J (2011)	1
BBS1	2	ALDOB	2	two hybrid, affinity chromatography technology	Oeffner F (2008), Oeffner F (2008)	2