PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC5L	2	AURKB	2	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	TPX2	4	affinity chromatography technology	Lleres D (2010)	1
TPX2	4	TWF1	2	biochemical	Havugimana PC (2012)	1
RNF111	2	TPX2	4	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	SCAMP3	0	affinity chromatography technology	Rodriguez J (2016)	1
RPA1	0	ZNF598	6	affinity chromatography technology	Marechal A (2014)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
AURKB	2	TPX2	4	affinity chromatography technology	Fu J (2009)	1
TPX2	4	AFAP1	3	affinity chromatography technology	Hein MY (2015)	1
8339	0	AURKB	2	bioid	Lambert JP (2015)	1
CDC5L	2	KPNB1	3	affinity chromatography technology	Lleres D (2010)	1
TPX2	4	UBE2S	2	biochemical	Havugimana PC (2012)	1
THUMPD2	0	TPX2	4	biochemical	Havugimana PC (2012)	1
RPA1	0	SCAMP3	0	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
BRCA1	7	KPNB1	3	affinity chromatography technology	Ertych N (2016)	1
FZR1	1	TPX2	4	affinity chromatography technology, affinity chromatography technology	Stewart S (2005), Stewart S (2005)	2
8339	0	TPX2	4	bioid	Lambert JP (2015)	1
CDC5L	2	GOLGA2	2	two hybrid	Rolland T (2014)	1
CDC5L	2	TWF1	2	affinity chromatography technology	Lleres D (2010)	1
RPA3	2	TPX2	4	affinity chromatography technology	Marechal A (2014)	1
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
RPA3	2	ZNF598	6	affinity chromatography technology	Marechal A (2014)	1
TPX2	4	ZNF598	6	biochemical	Havugimana PC (2012)	1
FZR1	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TPX2	4	KPNA1	5	affinity chromatography technology	Trieselmann N (2003)	1
ZNF598	6	SCAMP3	0	affinity chromatography technology	Garzia A (2017)	1
EGLN3	0	SERPINH1	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	CHUK	5	affinity chromatography technology	Fu J (2013)	1
TPX2	4	IKBKG	0	affinity chromatography technology	Irelan JT (2007)	1
NAP1L1	2	TPX2	4	two hybrid	Wang J (2011)	1
SERPINH1	2	TPX2	4	biochemical	Havugimana PC (2012)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
PPIF	0	MRPL53	0	biochemical	Havugimana PC (2012)	1
PPIF	0	TPX2	4	biochemical	Havugimana PC (2012)	1
TPX2	4	KPNB1	3	affinity chromatography technology	Trieselmann N (2003)	1
EGLN3	0	AURKB	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	NAP1L1	2	affinity chromatography technology	Rodriguez J (2016)	1
RPA3	2	SCAMP3	0	affinity chromatography technology	Marechal A (2014)	1
KPNA1	5	KPNB1	3	pull down, pull down, pull down, biochemical, affinity chromatography technology, pull down	Koehler M (1999), Percipalle P (1997), Plafker SM (2000), Havugimana PC (2012), Hein MY (2015), Tsujii A (2015)	6
ZNF598	6	KPNB1	3	affinity chromatography technology	Garzia A (2017)	1
RPA2	0	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
CDC5L	2	UBE2S	2	affinity chromatography technology	Lleres D (2010)	1
BRCA1	7	RPA1	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Suhasini AN (2011), Mok MT (2010), Tian F (2013)	3
AURKB	2	FZR1	1	affinity chromatography technology, affinity chromatography technology	Nguyen HG (2005), Nguyen HG (2005)	2
AURKA	1	CHUK	5	affinity chromatography technology	Irelan JT (2007)	1
TPX2	4	SAP130	2	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	AURKA	1	affinity chromatography technology	Rodriguez J (2016)	1
SARNP	0	TPX2	4	biochemical	Havugimana PC (2012)	1
LMNA	2	KPNA1	5	two hybrid	Dittmer TA (2014)	1
TPX2	4	CHUK	5	affinity chromatography technology	Irelan JT (2007)	1
RPA1	0	TPX2	4	affinity chromatography technology	Marechal A (2014)	1
UBE2S	2	ZNF598	6	biochemical	Havugimana PC (2012)	1
TPX2	4	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011), Hill SJ (2014)	3
EGLN3	0	TPX2	4	affinity chromatography technology	Rodriguez J (2016)	1
CDK6	0	TPX2	4	enzymatic study	Anders L (2011)	1
UBE2S	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, pull down	Williamson A (2009), Williamson A (2009), Williamson A (2009), Williamson A (2009), Williamson A (2009), Wang W (2013), Brown NG (2014), Kelly A (2014)	8
MAPK14	0	TPX2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	SIAH2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Nakayama K (2007), Nakayama K (2004), Nakayama K (2004), Gopalsamy A (2014), Gopalsamy A (2014)	5
NDUFA7	0	TPX2	4	biochemical	Havugimana PC (2012)	1
HDAC9	7	TPX2	4	affinity chromatography technology	Joshi P (2013)	1
RPA1	0	CDC5L	2	affinity chromatography technology, pull down, affinity chromatography technology	Marechal A (2014), Marechal A (2014), Lleres D (2010)	3
TPX2	4	IKBKB	1	affinity chromatography technology	Irelan JT (2007)	1
DNAJC8	0	TPX2	4	biochemical	Havugimana PC (2012)	1
RPA2	0	TPX2	4	affinity chromatography technology	Marechal A (2014)	1
AURKA	1	TPX2	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kufer TA (2002), Kufer TA (2002), Katayama H (2008), Trieselmann N (2003), Hutchins JR (2010), Maxwell CA (2011), Maxwell CA (2011), Fu J (2009), Huttlin EL (2015), Huttlin EL (2017), Ertych N (2016)	11
RPA2	0	SCAMP3	0	affinity chromatography technology	Marechal A (2014)	1
EGLN3	0	BRCA1	7	affinity chromatography technology	Rodriguez J (2016)	1
SIAH2	0	TPX2	4	two hybrid, affinity chromatography technology	Szczepanowski M (2007), Szczepanowski M (2007)	2
CDC5L	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Lleres D (2010), Depreux FF (2015)	2
LMNA	2	RPA1	0	biochemical	Wan C (2015)	1
SCAMP3	0	TPX2	4	biochemical	Havugimana PC (2012)	1
BRCA1	7	AFAP1	3	affinity chromatography technology	Hill SJ (2014)	1
THAP11	1	TPX2	4	two hybrid	Wang J (2011)	1
RPA3	2	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
BRCA1	7	NAP1L1	2	affinity chromatography technology	Ertych N (2016)	1
MRPL53	0	TPX2	4	biochemical	Havugimana PC (2012)	1
IKBKG	0	DNAJC8	0	pull down	Fenner BJ (2010)	1
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
EGLN3	0	KPNB1	3	affinity chromatography technology	Rodriguez J (2016)	1
RBPJ	1	TPX2	4	affinity chromatography technology	Li X (2015)	1
EGLN3	0	RPA3	2	affinity chromatography technology	Rodriguez J (2016)	1
AURKA	1	ZNF598	6	genetic interference	Horlbeck MA (2018)	1
AURKA	1	IKBKG	0	affinity chromatography technology	Irelan JT (2007)	1
AURKA	1	HMMR	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011), Maxwell CA (2011)	3
IKBKG	0	KPNA1	5	affinity chromatography technology	Hwang B (2015)	1
BRCA1	7	SERPINH1	2	affinity chromatography technology	Ertych N (2016)	1
FZR1	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IKBKB	1	EGLN3	0	affinity chromatography technology, pull down, affinity chromatography technology	Xue J (2010), Xue J (2010), Fu J (2013)	3
GOLGA2	2	TPX2	4	two hybrid	Rolland T (2014)	1
AURKA	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Irelan JT (2007), Irelan JT (2007), Irelan JT (2007)	3
RPA2	0	ZNF598	6	affinity chromatography technology	Marechal A (2014)	1
MAPK14	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
HMMR	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011), Hill SJ (2014), Ertych N (2016)	4
AURKA	1	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Ouchi M (2004), Ouchi M (2004), Maxwell CA (2011), Maxwell CA (2011), Ouchi M (2004), Ouchi M (2004), Ertych N (2016)	7
EGLN3	0	KPNA1	5	affinity chromatography technology	Rodriguez J (2016)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
EGLN3	0	HMMR	1	affinity chromatography technology	Rodriguez J (2016)	1
LMNA	2	TPX2	4	bioid	Roux KJ (2012)	1
RBPJ	1	RPA2	0	affinity chromatography technology	Li X (2015)	1
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
8339	0	BRCA1	7	bioid	Lambert JP (2015)	1
BRCA1	7	CDC5L	2	affinity chromatography technology	Ertych N (2016)	1
GSTM3	1	TPX2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TPX2	4	HMMR	1	affinity chromatography technology, affinity chromatography technology	Maxwell CA (2011), Maxwell CA (2011)	2