PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NINL	1	CDC20	1	affinity chromatography technology, affinity chromatography technology	Wang Y (2007), Wang Y (2007)	2
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
NINL	1	ZNF417	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
NINL	1	MCM10	2	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
FZR1	1	PLK1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Sedgwick GG (2012), Lee SB (2015), Williamson A (2011)	5
PLK1	0	TUBG1	2	affinity chromatography technology	Feng Y (1999)	1
PLK1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Zou J (2013), Zou J (2014)	2
CDC20	1	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Sedgwick GG (2012), Hyun SY (2013), Hyun SY (2013), Hyun SY (2013), Jia L (2016)	5
NINL	1	FZR1	1	affinity chromatography technology, affinity chromatography technology	Wang Y (2007), Wang Y (2007)	2
LRRC39	0	NINL	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NINL	1	TUBG1	2	affinity chromatography technology, imaging technique	Casenghi M (2003), Casenghi M (2003)	2
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
BRCA1	7	TUBG1	2	imaging technique, affinity chromatography technology, pull down, biochemical, imaging technique, affinity chromatography technology, enzymatic study, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Hsu LC (2001), Hsu LC (2001), Hsu LC (2001), Hsu LC (1998), Hsu LC (1998), Hsu LC (1998), Starita LM (2004), Brodie KM (2012), Tarapore P (2012), Tarapore P (2012), Tarapore P (2012), Matsuzawa A (2014)	12
NINL	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Jin S (2009), Jin S (2009)	2
NINL	1	RCOR3	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CDC20	1	TUBG1	2	affinity chromatography technology	Kim AH (2009)	1
RCOR3	0	LZTS2	4	two hybrid	Rolland T (2014)	1
RGS2	2	NINL	1	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
NINL	1	CCHCR1	2	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
LZTS2	4	ZNF417	2	two hybrid	Rolland T (2014)	1
NINL	1	PLK1	0	affinity chromatography technology, two hybrid, enzymatic study, bioid	Casenghi M (2003), Casenghi M (2003), Casenghi M (2003), Gupta GD (2015)	4