PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
HNRNPL	3	FBXO21	2	affinity chromatography technology	Fei T (2017)	1
COPS5	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
CFTR	5	SKP1	0	affinity chromatography technology	Pankow S (2015)	1
HNRNPL	3	ZBTB46	7	affinity chromatography technology	Fei T (2017)	1
FBXO21	2	EID2	0	affinity chromatography technology	Zhang C (2015)	1
TP53	0	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Jin X (2009), Watanabe G (2009)	2
FBXO21	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang C (2015), Zhang C (2015), Hauri S (2016)	3
TP53	0	FBXO21	2	affinity chromatography technology	Fogeron ML (2013)	1
TERF2	2	FBXO21	2	affinity chromatography technology	Giannone RJ (2010)	1
DLD	1	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
ARSG	2	FBXO21	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC73	1	CUL1	7	affinity chromatography technology	Herr P (2015)	1
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CDKN1A	1	NOV	0	pull down	Chen J (1996)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
DLD	1	SKP1	0	affinity chromatography technology	Malty RH (2017)	1
CFTR	5	FBXO21	2	affinity chromatography technology	Pankow S (2015)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
ELAVL1	0	TERF2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	SMURF1	4	affinity chromatography technology	Fei T (2017)	1
SMURF1	4	FBXO21	2	affinity chromatography technology	Cui Y (2011)	1
COPS6	0	FBXO21	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
CUL1	7	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
ZBTB46	7	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
KERA	0	EID2	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC73	1	FBXO21	2	affinity chromatography technology	Herr P (2015)	1
EID1	1	CUL1	7	affinity chromatography technology	Huttlin EL (2017)	1
IDS	0	FBXO21	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CNTNAP4	4	FBXO21	2	two hybrid	Nakayama M (2002)	1
CDKN1A	1	FBXO21	2	affinity chromatography technology	Fogeron ML (2013)	1
COPS5	0	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
VWCE	5	FBXO21	2	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	FBXO21	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXO21	2	EID1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology	Watanabe K (2015), Watanabe K (2015), Zhang C (2015), Zhang C (2015), Zhang C (2015), Zhang C (2015), Zhang C (2015), Zhang C (2015), Zhang C (2015), Huttlin EL (2017)	10
TP53	0	RBX1	2	affinity chromatography technology	Fogeron ML (2013)	1
HMGCL	2	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
CFTR	5	TP53	0	affinity chromatography technology	Pankow S (2015)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
DLD	1	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	CDKN1A	1	affinity chromatography technology	Yu ZK (1998)	1
ELAVL1	0	ZBTB46	7	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
CUL1	7	ZBTB46	7	affinity chromatography technology	Bennett EJ (2010)	1
SKP1	0	CDKN1A	1	imaging technique	Chen TC (2014)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CDKN1A	1	COPS6	0	two hybrid	Vinayagam A (2011)	1
ELAVL1	0	FBXO21	2	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXO21	2	RBX1	2	affinity chromatography technology	Watanabe K (2015)	1
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
KERA	0	FBXO21	2	affinity chromatography technology	Huttlin EL (2017)	1
NOV	0	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
SMURF1	4	PRKCA	7	enzymatic study	Andrews PS (2010)	1
COLEC11	0	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
ELAVL1	0	PRKCA	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Abdelmohsen K (2009), Chu PC (2012), Doller A (2007), Doller A (2007)	4
FAM219A	1	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
PRKCA	7	FBXO21	2	affinity chromatography technology	Huttlin EL (2017)	1
TERF1	1	FBXO21	2	affinity chromatography technology	Giannone RJ (2010)	1
NXF1	0	PRKCA	7	affinity chromatography technology	Castello A (2012)	1
CRYAB	0	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
NXF1	0	FBXO21	2	affinity chromatography technology	Castello A (2012)	1
CUL1	7	FBXO21	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Watanabe K (2015), Zhang C (2015), Zhang C (2015), Reitsma JM (2017)	5
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
IDS	0	CUL1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
TERF1	1	SKP1	0	pull down	Li Y (2010)	1